Synergistic Integration and Pharmacomechanical Function of Enzyme-Magnetite Nanoparticle Swarms for Low-Dose Fast Thrombolysis.

Magnetic micro-/nanoparticles are extensively explored over the past decade as active diagnostic/therapeutic agents for minimally invasive medicine. However, sufficient function integration on these miniaturized bodies toward practical applications remains challenging. This work proposes a synergistic strategy via integrating particle functionalization and bioinspired swarming, demonstrated by recombinant tissue plasminogen activator modified magnetite nanoparticles (rtPA-Fe O NPs) for fast thrombolysis in vivo with low drug dosage.

Convenient, nondestructive monitoring and sustained-release of ethephon/chitosan film for on-demand of fruit ripening.

The microstructure changes (such as micro defects and free volume, etc.) is a deep factor that determines the sustained release behavior of polymer film. However, there are few reports exploring the micro defects of sustained-release materials.

Importance of Robust and Reliable Nanochannel Sealing for Enhancing Drug Delivery Efficacy of Hollow Mesoporous Nanocontainer.

Hollow mesoporous silica nanoparticles (HMSNPs) have been widely explored in the biomedical field as drug delivery nanocarriers by virtue of their large hollow cavity. However, the connectivity between the internal cavity and the outside environment by numerous nanochannels on the mesoporous shell allows for possible drug leakage, leading to nonsufficient drug loading due to unreliable capping of the nanopores. In addition, the issue of ensuring effective utilization of the hollow cavity for achieving high drug loading capacity of HMSNPs is seldom addressed.

Facile Method To Prepare a Novel Biological HKUST-1@CMCS with Macroscopic Shape Control for the Long-Acting and Sustained Release.

We have developed a green and versatile method to prepare hierarchically porous Cu(BTC)@carboxymethyl chitosan (HKUST-1@CMCS) with a macroscopic shape control and designable performance via the cross-linking of Cu(II) ions with CMCS. Furthermore, atomic force microscopy, scanning electron microscopy, powder X-ray diffraction, Brunauer-Emmett-Teller, and X-ray photoelectron spectroscopy analyses showed that the morphology of HKUST-1 could be controlled and changed by tailoring the surface roughness ( R) of polymer matrix. For the ball-like, fiberlike, and membrane-like composites, the matrix R values were 887, 88.

Large-scale synthesis of monodisperse Prussian blue nanoparticles for cancer theranostics via an "in situ modification" strategy.

Background: The intrinsic properties of Prussian blue (PB) nanoparticles make them an attractive tool in nanomedicine, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and photothermal therapy (PTT) properties. However, there still remains the challenge of their poor dispersible stability in the physiological environment. In this study, we developed an efficient hydrothermal method to address the poor dispersible stability of PB nanoparticles in the physiological environment.

Adsorption of Cu(ii), Zn(ii), and Pb(ii) from aqueous single and binary metal solutions by regenerated cellulose and sodium alginate chemically modified with polyethyleneimine.

In this paper, crosslinked cellulose/sodium alginate (SA) was modified with polyethyleneimine (PEI) as an adsorbent (PEI-RCSA) for comparative and competitive adsorption of Cu(ii), Zn(ii), and Pb(ii) in single and binary aqueous solutions. FTIR, SEM, TGA and specific surface area analysis were used to characterize the structural characteristics of PEI-RCSA. The effects of initial pH of solutions, contact time and initial concentration of heavy metal ions on the adsorption capacity of PEI-RCSA were investigated.

Intermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.

Magnetic-hyperthermia-ablation is considered as an effective and minimally invasive technology for tumor therapy. However, inappropriate temperature control could induce an excessively high temperature which brings potential safety problems and limits clinical transformation of this technique. Herein, aiming to control the temperature during magnetic hyperthermia ablation, we develop an intermittent time-set technique for temperature control in magnetic hyperthermia ablation of tumors using a polylactic--glycolic acid (PLGA)-FeO implant.

Injectable and thermally contractible hydroxypropyl methyl cellulose/FeO for magnetic hyperthermia ablation of tumors.

The development of efficient strategies for the magnetic hyperthermia ablation of tumors remains challenging. To overcome the significant safety limitations, we developed a thermally contractible, injectable and biodegradable material for the minimally invasive and highly efficient magnetic hyperthermia ablation of tumors. This material was composed of hydroxypropyl methyl cellulose (HPMC), polyvinyl alcohol (PVA) and FeO.

A thermoplastic elastomer patch matrix for traditional Chinese medicine: design and evaluation.

Objective: To design and evaluate a novel pressure sensitive adhesive (PSA) patch containing traditional Chinese medicine (TCM) using styrene-isoprene-styrene (SIS) copolymer.

Method: A mixture D-optimal design with ternary response surface diagram was employed in the optimization process. The proportions of SIS copolymer, tackifying resin and plasticizer were selected as the independent variables while tack force, peel strength of the patch and skin penetrability of methyl salicylate were selected as the dependent variables.

A drug-in-adhesive matrix based on thermoplastic elastomer: evaluation of percutaneous absorption, adhesion, and skin irritation.

A novel drug-in-adhesive matrix was designed and prepared. A thermoplastic elastomer, styrene-isoprene-styrene (SIS) block copolymer, in combination with tackifying resin and plasticizer, was employed to compose the matrix. Capsaicin was selected as the model drug.

Evaluation of drug release profile from patches based on styrene-isoprene-styrene block copolymer: the effect of block structure and plasticizer.

We prepared pressure-sensitive adhesive (PSA) patches based on styrene-isoprene-styrene (SIS) thermoplastic elastomer using hot-melt coating method. The liquid paraffine is added in the PSA matrices as a plasticizer to moderate the PSA properties. Three drugs, methyl salicylate, capsaicin, and diphenhydramine hydrochloride are selected as model drugs.