Publications by authors named "Xiuzhen Li"

Latexin (LXN) is a secreted protein with a molecular weight of 29 KD, which is considered a tumor suppressor and plays an important role in the inflammatory immune response. LXN is highly expressed in macrophages and regulates macrophage polarity and tumor immune escape, demonstrating excellent clinical potential. However, its mechanism is still unclear.

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Ongoing wind energy developments play a key role in mitigating the global effects of climate change and the energy crisis; however, they have complex ecological consequences for many flying animals. The Yellow Sea coast is considered as an ecological bottleneck for migratory waterbirds along the East Asian-Australasian flyway (EAAF), and is also an important wind farm base in China. However, the effects of large-scale onshore wind farms along the EAAF on multidimensional waterbird diversity, and how to mitigate these effects, remain unclear.

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Iron (Fe) oxides in wetland soils are crucial for stabilizing soil organic carbon (SOC) by forming stable Fe-OC complexes, thus protecting SOC from microbial breakdown and aiding its preservation. This study delves into the response of Fe (hydr-)oxides to salt stress, a relatively unexplored area, by examining Kandelia obovata, a key mangrove species. Through controlled climate chamber experiments, we investigated how salt stress affects the interactions between Fe (hydr-)oxides and SOC in root exudates (REs) and rhizosphere soils.

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Excessive tyrosinase expression leads to pigmented diseases in humans and browning in plants, necessitating effective tyrosinase inhibitors. This study investigated the inhibitory effect and mechanism of 7-hydroxycoumarin-3-carboxylic acid (7-HC-3-CA) on tyrosinase. Using UV-visible absorption spectroscopy, we found that 7-HC-3-CA effectively inhibited tyrosinase activity, with an IC value of 364 ± 1.

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The immune defense and the repair function of the pulp tissue serve as the biological foundation of pulpotomy. The precise evaluation of the pulp inflammation extent and determining its reversibility are essential for the success of pulpotomy. The objective of this study was to classify the molecular-level of dental pulp cell physiology and inflammatory state based on the biochemical changes obtained by single-cell Raman spectroscopy.

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Emulating biological perception mechanisms to construct intelligent sensing devices and systems represents a paradigm for promoting human-computer interaction in the Internet of Everything era. Nonetheless, developing highly sensitive, real-time sensing and rapidly integrated intelligent interaction units remains a challenging and time-consuming endeavor. This study employs a low-temperature glow discharge technique to rapidly fabricate graded nanotexturing architectural triboelectric nanopaper, upon which wearable triboelectric sensors for real-time tactile detection are designed.

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Introduction: Nonketotic hyperglycinemia (NKH) is a rare, life-threatening genetic disorder. The patients usually show heterogeneous and nonspecific symptoms, resulting in diagnosis challenges using conventional approaches. Here, the clinical presentation and genetic features of 20 Chinese patients were examined and reported in order to clarify the natural history and prognosis of NKH in China.

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Article Synopsis
  • - The study compares the effectiveness of three blood culture media (BACT/ALERT FA/FN Plus from France, DL from China, and REDOX from the USA) in recovering microorganisms from blood samples containing antimicrobials, revealing that BACT/ALERT significantly outperformed the other two in both aerobic and anaerobic conditions.
  • - Recovery rates for the media showed BACT/ALERT with 87.5% and 91.4% recovery in aerobic and anaerobic conditions, respectively, while DL and REDOX showed much lower rates, especially under anaerobic conditions (2.9% for DL and 14.3% for REDOX).
  • - The study highlights the need for improved neutralization
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Traditionally, the D1228 E/G/H/N mutation has been thought to cause Type I MET-TKI resistance. We reported a 75-year-old female with non-small cell lung cancer harboring MET exon 14 skipping mutation, who developed acquired MET D1228H mutation induced by capmatinib treatment. Interestingly, the patient demonstrated marked response to second-line savolitinib treatment with the duration of response of 19 months and several additional metastatic lesions appeared.

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Background: Midwives experience elevated levels of work-related stress. However, there is limited understanding of the patterns of this stress, its sociodemographic and work-related determinants, and its association with sub-health.

Method: This multi-center cross-sectional study, conducted in 21 hospitals in Zhuhai City, Guangdong Province, China, involved 300 midwives.

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  • Isoleucine-proline-proline (IPP) is a natural tripeptide that inhibits angiotensin-converting enzyme (ACE), playing a role in reducing hypertension and sympathetic activity in a rat study.
  • The study involved male Sprague-Dawley rats with induced hypertension, showing that IPP injections into the brain and bloodstream effectively lowered both sympathetic nerve activity and blood pressure by mitigating ACE activity and oxidative stress.
  • Long-term treatment with IPP also led to significant reductions in hypertension and vascular changes, highlighting its potential as a therapeutic approach for managing high blood pressure.
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  • Dwarfing rootstocks improve peach cultivation by increasing planting density, reducing tree height, and requiring less labor, while also promoting rapid growth and fruiting potential.
  • In a study, the scion Ruipan 4 was grafted onto two different rootstocks, revealing that the combination with rootstock O resulted in shorter plants with more flower buds compared to the combination with rootstock M.
  • Analysis of gene expression demonstrated that specific genes related to gibberellin (GA) metabolism play a key role in the dwarfing effect, with the transcription factor PpGATA21 activating these genes to lower GA levels and induce the dwarfing of the plants.
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River deltas, such as the Ganges-Brahmaputra-Meghna (GBM) delta, are highly vulnerable to flooding, exacerbated by intense human activities and rapid urban growth. This study explores the evolution of urban flood risks in the GBM delta under the combined impacts of climate change and urban expansion. Unlike traditional assessments that focus on a single flood source, we consider multiple sources-coastal, fluvial, and pluvial.

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Rhombohedral-stacked transition-metal dichalcogenides (3R-TMDs), which are distinct from their hexagonal counterparts, exhibit higher carrier mobility, sliding ferroelectricity, and coherently enhanced nonlinear optical responses. However, surface epitaxial growth of large multilayer 3R-TMD single crystals is difficult. We report an interfacial epitaxy methodology for their growth of several compositions, including molybdenum disulfide (MoS), molybdenum diselenide, tungsten disulfide, tungsten diselenide, niobium disulfide, niobium diselenide, and molybdenum sulfoselenide.

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Condensed tannins were isolated from the bark of Ficus altissima and fractionated into four subcomponents on a Sephadex LH-20 column with 60 %, 80 %, 100 % methanol, and 70 % acetone, separately. Their structures were characterized by MALDI-TOF MS coupled with HPLC-ESI-MS and confirmed to be polymers of B-type procyanidin glucosides, procyanidins, and prodelphinidin glucosides. The degree of polymerization (DP) of these polymers was as high as 21, and the mDPs of the four subcomponents were calculated as 2.

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Introduction: Epstein-Barr virus-positive (EBV+) inflammatory follicular dendritic cell (FDC) sarcoma is a rare neoplasm characterized by spindle-shaped follicular dendritic cells, marked lymphoplasmacytic infiltration, and a consistent link to EBV. While it typically affects the liver and spleen, it is exceptionally rare in the digestive tract. We present a special case of EBV + inflammatory FDC sarcoma arising in the colon with clonal immunoglobulin (IG) gene rearrangement.

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Noncontact sensing technology serves as a pivotal medium for seamless data acquisition and intelligent perception in the era of the Internet of Things (IoT), bringing innovative interactive experiences to wearable human-machine interaction perception networks. However, the pervasive limitations of current noncontact sensing devices posed by harsh environmental conditions hinder the precision and stability of signals. In this study, the triboelectric nanopaper prepared by a phase-directed assembly strategy is presented, which possesses low charge transfer mobility (1618 cm V s) and exceptional high-temperature stability.

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Enhancing the ability of coastal blue carbon to accumulate and store carbon and reduce net greenhouse gas emissions is an essential component of a comprehensive approach for tackling climate change. The annual winter harvesting of Phragmites is common worldwide. However, the effects of harvesting on methane (CH) emissions and its potential as an effective blue carbon management strategy have rarely been reported.

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Background: Methylmalonic aciduria (MMA) is a group of rare genetic metabolic disorders resulting from defects in methylmalonyl coenzyme A mutase (MCM) or intracellular cobalamin (cbl) metabolism. MMA patients show diverse clinical and genetic features across different subtypes and populations.

Methods: We retrospectively recruited 60 MMA patients from a single center and diagnosed them based on their clinical manifestations and biochemical assays.

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Article Synopsis
  • Asprosin, a protein hormone linked to metabolic diseases, was found to affect the proliferation and migration of vascular smooth muscle cells (VSMCs) in a rat model of hypertension, indicating its potential role in cardiovascular diseases.
  • The study showed that asprosin levels were higher in the VSMCs of hypertensive rats, and it promoted their proliferation and migration by increasing the activity of Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and superoxide production.
  • Knocking down asprosin reduced VSMC proliferation and migration, suggesting that targeting asprosin could help alleviate vascular remodeling and high blood pressure in hypertensive conditions.
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Large-scale, high-quality, and uniform monolayer molybdenum disulfide (MoS) films are crucial for their applications in next-generation electronics and optoelectronics. Epitaxy is a mainstream technique for achieving high-quality MoS films and is demonstrated at a wafer scale up to 4-in. In this study, the epitaxial growth of 8-in.

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Background: The genus Sulfitobacter, a member of the family Roseobacteraceae, is widely distributed in the ocean and is believed to play crucial roles in the global sulfur cycle. However, gene clusters associated with sulfur oxidation in genomes of the type strains of this genus have been poorly studied. Furthermore, taxonomic errors have been identified in this genus, potentially leading to significant confusion in ecological and evolutionary interpretations in subsequent studies of the genus Sulfitobacter.

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To investigate the relationship between serum uric acid level and glomerular ischemic lesions (GIL) in patients with primary membranous nephropathy (PMN) and identify relevant risk factors. A total of 201 patients with PMN but normal renal function confirmed by renal biopsy executed in the Liaocheng People's Hospital, China, during January 2020-January 2023 were analyzed retrospectively. The enrolled patients were divided into a hyperuricemia group and a normal serum uric acid group (control group) according to their serum uric acid levels.

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DepA, a pyrroloquinoline quinone (PQQ)-dependent enzyme isolated from mutans 17-2-E-8, exhibits versatility in oxidizing deoxynivalenol (DON) and its derivatives. This study explored DepA's substrate specificity and enzyme kinetics, focusing on DON and 15-acetyl-DON. Besides efficiently oxidizing DON, DepA also transforms 15-acetyl-DON into 15-acetyl-3-keto-DON, as identified via LC-MS/MS and NMR analysis.

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Objective: This study aimed to explore the clinical and genetic features of Chinese patients with mucopolysaccharidosis type VII (MPS VII), thereby improving early detection, disease management, and patient outcomes.

Methods: A retrospective review of medical records for five patients presenting with coarse facial features, rib protrusion, chest deformities, and scoliosis was conducted. Exome sequencing was employed to identify causative genetic mutations.

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