Publications by authors named "Xiuyu Cao"

The health effects of traffic-derived pollutants have gathered increasing concerns. Our objectives were to evaluate the associations of traffic-related heavy metal exposure with serum uric acid (SUA) and hyperuricemia and to explore the underlying mechanism. Traffic-related heavy metals (including zinc, iron, manganese, copper, lead, cadmium, antimony, and barium) and SUA were determined among 3909 community-based adults from the Wuhan-Zhuhai cohort.

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The associations of polycyclic aromatic hydrocarbon (PAH) exposure with serum uric acid (SUA) or hyperuricemia have been rarely assessed. We aimed to investigate the relationships between urinary PAH metabolites and SUA or hyperuricemia among US adults and to explore the mediating role of systemic inflammation in the associations. A total of 10,307 US adults were conducted to assess the associations of seven urinary hydroxy‑PAH with SUA and hyperuricemia and evaluate the role of C-reactive protein (CRP), a biomarker of systemic inflammation, in such associations.

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Article Synopsis
  • - The study investigated the relationship between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and levels of serum uric acid (SUA) and hyperuricemia (HUA) risk among over 4,000 Chinese urban residents, with a 6-year follow-up for a subset of participants.
  • - Results showed that each unit increase in certain PAH metabolites was linked to significant increases in SUA levels and a higher risk of developing HUA, with specific increases ranging between 4.10 to 7.67 μmol/L for SUA and 14% to 27% for HUA risk.
  • - The study concluded that PAH exposure led to higher SUA levels and increased HUA risk,
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  • - Polychlorinated biphenyls (PCBs) are harmful chemicals linked to health issues, and this study looked at how they relate to dyslipidemia (abnormal lipid levels in the blood), considering genetic and lifestyle factors.
  • - Researchers analyzed serum levels of six specific PCBs in nearly 4,000 participants and found that higher PCB concentrations were associated with increased cases of hypercholesterolemia, hypertriglyceridemia, and elevated low-density lipoprotein (LDL) cholesterol levels.
  • - The study indicated that individuals with high PCB exposure, combined with an unhealthy lifestyle and high genetic risk, experienced significantly greater odds of developing dyslipidemia compared to those with lower PCB exposure and
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Exposure of dichlorodiphenyltrichloroethane (DDT) pesticide was suggested to be associated with adverse effects on the respiratory system. However, the effects of DDT exposure on lung function remain unclear. Our objectives were to investigate the potential associations of internal levels of DDT and its metabolites including dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) with lung function.

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Adverse health effects of ambient ozone are getting widespread attention, but the evidence on the relationship between ozone levels and circulatory system diseases are limited and inconsistent. Daily data for ambient ozone levels and hospitalizations for total circulatory diseases and five subtypes in Ganzhou, China from January 1, 2016 to December 31, 2020 were collected. We constructed a generalized additive model with quasi-Poisson regression accounting for lag effects to estimate the associations between ambient ozone levels and the number of hospitalized cases of total circulatory diseases and five subtypes.

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Objective: Previous epidemiological studies have shown that both long-term and short-term exposure to fine particulate matters (PM) were associated with the morbidity and mortality of circulatory system diseases (CSD). However, the impact of PM on CSD remains inconclusive. This study aimed to investigate the associations between PM and circulatory system diseases in Ganzhou.

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