Publications by authors named "Xiuxue Mo"
Giant cell myocarditis (GCM) is a rare, usually rapidly progressive, and potentially fatal disease. Detailed inflammatory responses remain unknown, in particular the formation of multinucleate giant cells. We performed single-cell RNA sequencing analysis on 15,714 cells extracted from the hearts of GCM rats and normal rats.
View Article and Find Full Text PDFThe matricellular protein, follistatin-like 1 (FSTL1), regulates lung development and saccular formation. Here, we employed single-cell RNA sequencing (scRNA-seq) to construct a transcriptomic atlas of 22,774 individual cells from wild-type (WT) and Fstl1 lung (E18.5) samples and identified 27 cell subtypes.
View Article and Find Full Text PDFArticle Synopsis
- Macrophages are crucial in autoimmune myocarditis, and this study focuses on the role of the Stimulator of interferon genes (Sting) in the disease's development.
- Researchers used mice to analyze how Sting influences the differentiation of proinflammatory macrophages during the acute phase of autoimmune myocarditis, revealing a link between Sting and the hypoxia-inducible factor-1α (Hif1α) in promoting inflammation.
- The findings suggest that blocking the STING pathway may reduce cardiac inflammation and present a new therapeutic target for treating autoimmune myocarditis in patients.