Welan gum has been widely used in harsh reservoir development, such as good thickening ability, temperature and salt resistance. However, viscoelasticity is crucial to polymer injectability and microscopic displacement efficiency, Welan gum have rigid helical conformation and show poor rheological properties., therefore, we proposed a double network strategy to improve the molecular conformation and rheological properties of Welan gum.
View Article and Find Full Text PDFCO flooding plays a crucial role in enhancing oil recovery and achieving carbon reduction targets, particularly in unconventional reservoirs with complex pore structures. The phase behavior of CO and hydrocarbons at different scales significantly affects oil recovery efficiency, yet its underlying mechanisms remain insufficiently understood. This study improves existing thermodynamic models by introducing Helmholtz free energy as a convergence criterion and incorporating adsorption effects in micro- and nano-scale pores.
View Article and Find Full Text PDFThe low cost and environmental advantages of Xanthan gum make its production and application scale exceed that of other polysaccharides. However, the temperature resistance of Xanthan gum limits its application. In this study, polysaccharide supramolecular Xanthan gum network (XG-β-CD/AD) based on β-cyclodextrin and adamantane was prepared for enhanced oil recovery.
View Article and Find Full Text PDFAdhesion is an intrinsic property of rocks and liquids. Investigating the factors contributing to its formation and the mechanisms governing its action is crucial for elucidating the adhesion work between solids and liquids. The adhesion work, serving as a parameter that characterizes the energy changes during the solid-liquid contact process, is a vital tool for probing this phenomenon.
View Article and Find Full Text PDFThe development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. The mechanisms of morphine tolerance are poorly understood. Mitochondria-derived reactive oxygen species (ROS) is a crucial signal inducing analgesic tolerance and pain.
View Article and Find Full Text PDFPostoperative pain is a common form of acute pain that, if not managed effectively, can become chronic pain. Evidence has shown that glia, especially microglia, mediate neuroinflammation, which plays a vital role in pain sensitization. Moreover, toll-like receptor 4 (TLR4), the tumor necrosis factor receptor (TNF-R), the interleukin-1 receptor (IL-1R), and the interleukin-6 receptor (IL-6R) have been considered key components in central pain sensitization and neuroinflammation.
View Article and Find Full Text PDFJ Neuroinflammation
April 2017
Background: Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1β production.
View Article and Find Full Text PDFBackground: The development of antinociceptive tolerance following repetitive administration of opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord plays a critical role in morphine tolerance. The inhibitor of microglia is effective to attenuate the tolerance; however, the mechanism is not fully understood.
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