Lead-Free Perovskite With Efficient Tellurium Ion Activation for Multifunctional Applications.

Lead-free perovskite materials have received extensive attention due to their non-toxicity, super environmental stability and adjustable photoelectric properties. However, the inherent problems of low luminous efficiency and low photoluminescence quantum yields (PLQYs) limit its development in multifunctional applications. Here, Te doped CsZrCl with high luminous efficiency and stability for multifunctional applications are developed.

Sulforaphane and ophthalmic diseases.

Sulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is CHNOS. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including anti-diabetic, anti-inflammatory, antimicrobial, anti-angiogenic, and anticancer attributes.

Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B.

Aim: To evaluate the role of semaphorin 7A (Sema7A) and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells (HCEs).

Methods: Barrier models of HCEs were treated with recombinant human Sema7A at concentrations of 0, 125, 250, or 500 ng/mL for 24, 48, or 72h . Transepithelial electrical resistance (TEER) as well as Dextran-fluorescein isothiocyanate (FITC) permeability assays were conducted to assess barrier function.

Mixed-attitude three-way decision model for aerial targets: Threat assessment based on IF-VIKOR-GRA method.

Assessing potential threats typically necessitates the use of a robust mathematical model, a comprehensive evaluation method and universal decision rules. A novel approach is utilized in this study to optimize existing threat assessment (TA) algorithms and three-way decision models (3WDMs) are leveraged that incorporate decision-theoretic rough sets (DTRSs) within dynamic intuitionistic fuzzy (IF) environments to create a mixed-attitude 3WDM based on the IF-VIKOR-GRA method in the context of aviation warfare. The primary objectives of this study include determining conditional probabilities for IF three-way decisions (3WDs) and establishing mixed-attitude decision thresholds.

17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblasts Smads and MAPK signaling pathways.

Aim: To investigate the impact of 17β-estradiol on the collagen gels contraction (CGC) and inflammation induced by transforming growth factor (TGF)-β in human Tenon fibroblasts (HTFs).

Methods: HTFs were three-dimensionally cultivated in type I collagen-generated gels with or without TGF-β (5 ng/mL), 17β-estradiol (12.5 to 100 µmol/L), or progesterone (12.

Tailor Traps in Bi-Doped NaGdGeO Phosphors by Introducing Eu Ions to Switch Multimodal Phosphorescence Emission.

Featured with a tunable excitation/emission wavelength and excellent physicochemical stability, inorganic fluorescent materials are widely used in the fields of anti-counterfeiting. Here, we design a multi-stimuli-responsive dynamic fluorescence and phosphorescence anti-counterfeiting material by introducing Eu ions in NaGdGeO: Bi to tailor the trap structure. The photoluminescence (PL), long persistent luminescence (LPL), and photo-stimulated luminescence (PSL) colors of NaGdGeO: Bi, Eu can be switched by varying the excitation modes (ultraviolet, near infrared, and X-ray light).

Triterpenoid saponins from Psammosilene tunicoides and their antinociceptive activities.

Herein, five undescribed oleanane-type triterpenoid saponins, namely, psammosaponins A-E, along with nine known compounds, were isolated from the roots of Psammosilene tunicoides. Moreover, part of the ethanolic extract of P. tunicoides was acid-hydrolyzed and three aglycones were isolated from the resulting hydrolysate.

Luteolin ameliorates cornea stromal collagen degradation and inflammatory damage in rats with corneal alkali burn.

Corneal alkali burn (AB) is a blindness-causing ocular trauma commonly seen in clinics. An excessive inflammatory reaction and stromal collagen degradation contribute to corneal pathological damage. Luteolin (LUT) has been studied for its anti-inflammatory effects.

The Conserved Transcriptional Activation Activity Identified in Dual-Specificity Tyrosine-(Y)-Phosphorylation-Regulated Kinase 1.

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 (DYRK1) encodes a conserved protein kinase that is indispensable to neuron development. However, whether DYRK1 possesses additional functions apart from kinase function remains poorly understood. In this study, we firstly demonstrated that the C-terminal of ascidian DYRK1 (CrDYRK1) showed transcriptional activation activity independent of its kinase function.

Magnesium deficiency stress in rice can be alleviated by partial nitrate nutrition supply.

The problem of nitrogen (N) excess and magnesium (Mg) deficiency in farmland is becoming more common, severe, and widespread in southern China. Magnesium is known to be an essential nutrient for higher plants; however, the physiological responses of field crops to Mg deficiency, particularly to its interaction with N forms, remain largely unknown. In this study, a hydroponic experiment was conducted using three Mg levels (0.

Mechanoluminescence from an Ion-Irradiated Single Crystal of Lithium Niobium Oxide.

Mechanoluminescence (ML) is a well-known phenomenon that has a wide range of applications in security monitoring, biomechanical sensing, and displays. Although several mechanisms relating to ML have been proposed, significant ambiguity persists due to the coexistence of crystal boundaries, luminescence centers, and defects within the samples, making them hard to disentangle. Here we preclude such ambiguity by using a Kr-irradiated single crystal of lithium niobium oxide (LiNbO) as the ML materials so that oxygen vacancies are retained to modulate the ML properties.

Inhibitory effects of luteolin on TLR3-mediated inflammation caused by TAK/NF-κB signaling in human corneal fibroblasts.

Aim: To study the role of luteolin (LUT) in the expression of toll-like receptors 3 (TLR3) ligand polyI:C stimulated inflammatory factors in human corneal fibroblasts (HCFs).

Methods: HCFs cells were cultivated with or without LUT or polyI:C. The expression levels of interleukin (IL)-6, IL-8, monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule (VCAM)-1, as well as intercellular adhesion molecule (ICAM)-1 were measured using enzyme-linked immunosorbent assay (ELISA), immunoblotting or reverse transcription-quantitative polymerase chain reaction (PCR) analyses.

Sulforaphane inhibits cytokine-stimulated chemokine and adhesion molecule expressions in human corneal fibroblasts: Involvement of the MAPK, STAT, and NF-κB signaling pathways.

Chemokines and adhesion molecules are major inflammatory mediators of chronic and recurrent vernal keratoconjunctivitis (VKC). Sulforaphane (SFN) is a natural plant extract that is known to have anti-inflammatory and antioxidant properties. SFN is demonstrated to be effective against a variety of human diseases.

Effective Repeatable Mechanoluminescence in Heterostructured Li Na NbO : Pr.

Mechanoluminescence (ML) is a striking optical phenomenon that is achieved through mechanical to optical energy conversion. Here, a series of Li Na NbO : Pr (x = 0, 0.2, 0.

Inhibition of TGF-β2-induced migration and epithelial-mesenchymal transition in ARPE-19 by sulforaphane.

Aim: To investigate the effects of sulforaphane (SFN) on transforming growth factor (TGF)-β2 stimulated migration and epithelial-mesenchymal transition (EMT) in ARPE-19 cells.

Methods: ARPE-19 cells were cultured in the presence or absence of SFN or TGF-β2. SFN toxicity was assessed by performing a lactate dehydrogenase assay (LDH) and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assays, and cell migration was evaluated by Transwell migration assay.

Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts.

Viral corneal infection is a common cause of visual impairment and blindness. Polyinosinic‑polycytidylic acid, or poly(I:C), is similar to viral double‑stranded RNA in structure and has been implicated in the release of a variety of cytokines, chemokines and matrix metalloproteinases (MMPs) by corneal fibroblasts. Sulforaphane (SFN) is an isothiocyanate compound found in cruciferous vegetables.

Alarmins from conjunctival fibroblasts up-regulate matrix metalloproteinases in corneal fibroblasts.

Aim: To explore the effects of alarmins produced by necrotic human conjunctival fibroblasts on the release of matrix metalloproteinases (MMPs) by human corneal fibroblasts (HCFs).

Methods: A necrotic cell supernatant (NHCS) was prepared by subjecting human conjunctival fibroblasts to three cycles of freezing and thawing. The amounts of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in NHCS were determined by enzyme-linked immunosorbent assays.

Achieving high thermal stability of different rare-earth ions in a single matrix host via the manipulation of the local structure by a solid solution.

Thermal quenching seriously restricts the practical application of phosphors, particularly under high temperature and long-term working conditions. Here, we demonstrate that the as-obtained series of solid solutions of Ca2-xYxAl2Si1-xAlxO7:Tb3+ (x = 0-1, Ca2Al2SiO7 → CaYAl3O7) phosphors exhibit an adjustable optical performance, where CaYAl3O7:Tb3+ exhibits a greatly improved thermal stability with a shortened bond distance of the related polyhedron compared with Ca2Al2SiO7:Tb3+. The shrunken bond distance strengthens the pressure of the local structure and suppresses the non-radiative transition effectively, contributing to the prevention of the thermal degradation.

Genomic basis of environmental adaptation in the leathery sea squirt (Styela clava).

Tunicates occupy the evolutionary position at the boundary of invertebrates and vertebrates. It exhibits adaptation to broad environmental conditions and is distributed globally. Despite hundreds of years of embryogenesis studies, the genetic basis of the invasive habits of ascidians remains largely unknown.

Inhibition of Gap Junction-Mediated Intercellular Communication by Poly(I:C) in Cultured Human Corneal Fibroblasts.

Purpose/aim: Corneal stromal fibroblasts are connected to each other via gap junctions, which contribute to maintenance of corneal homeostasis. Viral infection of the corneal stroma can result in inflammation and scarring. The effects of polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, on gap junctional intercellular communication (GJIC) in cultured human corneal fibroblasts (HCFs) were examined.

Detection of Cell Viability via Fluorescence Labeling of Silicate Phosphor with a Low-Temperature Superlong Persistent Luminescence.

Cell viability detection is usually accompanied by large errors and toxicity. For the accuracy and safety of detection, it is urgent to develop a practical approach to realize the real-time monitoring of cell viability. Here, a low-temperature persistent phosphor was employed to facilitate the detection of cell viability.

Biomechanics analysis of human walking with load carriage.

Background: Comprehensive analysis of the inherent laws and the biomechanic principles of human walking with load carriage and building kinematics, and kinematics model of human walking with load carriage, are very meaningful for the development of devices and apparatus that are related to human walking with load carriage, such as a lower limb exoskeleton.

Objective: The gait experiment of human walking with load carriage is designed and performed in this paper.

Methods: The obtained video is marked and analyzed by using SIMI motion analytical software.

Transforming growth factor-β2 induces morphological alteration of human corneal endothelial cells in vitro.

Aim: To investigate the morphological altering effect of transforming growth factor-β2 (TGF-β2) on untransfected human corneal endothelial cells (HCECs) in vitro.

Methods: After untransfected HCECs were treated with TGF-β2 at different concentrations, the morphology, cytoskeleton distribution, and type IV collagen expression of the cells were examined with inverted contrast light microscopy, fluorescence microscopy, immunofluorescence or Western Blot.

Results: TGF-β2 at the concentration of 3-15 µg/L had obviously alterative effects on HCECs morphology in dose and time-dependent manner, and 9 µg/L was the peak concentration.

Comparison of Combined Phacoemulsification, Intraocular Lens Implantation, and Goniosynechialysis With Phacotrabeculectomy in the Treatment of Primary Angle-Closure Glaucoma and Cataract.

Purpose: This study aimed to compare the efficacy and safety of combined phacoemulsification, intraocular lens implantation, and goniosynechialysis with phacotrabeculectomy in the treatment of primary angle-closure glaucoma (PACG) and cataract.

Design: A comparative case series.

Methods: Sixty-five patients (65 eyes) with PACG and cataract from the Fifth Affiliated Hospital of Sun Yat-Sen University were enrolled for this study between October 2009 and July 2011.