A surgical mouse model of neonatal right ventricular outflow tract obstruction by pulmonary artery banding.

Backgroud: Diseased animal models play an extremely important role in preclinical research. Lacking the corresponding animal models, many basic research studies cannot be carried out, and the conclusions obtained are incomplete or even incorrect. Right ventricular (RV) outflow tract (RVOT) obstruction leads to RV pressure overload (PO) and reduced pulmonary blood flow (RPF), which are 2 of the most important pathophysiological characteristics in pediatric cardiovascular diseases and seriously affect the survival rate and long-term quality of life of many children.

Development and validation of a prognostic nomogram for predicting cancer-specific survival in advanced endometrial carcinoma after surgery: a retrospective analysis of the SEER Database.

Objective: We aimed to construct and validate a prognostic nomogram to predict cancer-specific survival (CSS) after surgery in patients with advanced endometrial carcinoma (EC).

Design: Retrospective cohort study.

Setting And Participants: The Surveillance, Epidemiology, and End Results (SEER) Database contains cancer incidence and survival data from population-based cancer registries in the USA.

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model.

Right ventricular (RV) volume overload (VO) is common in children with congenital heart disease. In view of distinct developmental stages,the RV myocardium may respond differently to VO in children compared to adults. The present study aims to establish a postnatal RV VO model in mice using a modified abdominal arteriovenous fistula.

Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms.

Clinical observation indicates that exercise capacity, an important determinant of survival in patients with congenital heart disease (CHD), is most decreased in children with reduced pulmonary blood flow (RPF). However, the underlying mechanism remains unclear. Here, we obtained human RPF lung samples from children with tetralogy of Fallot as well as piglet and rat RPF lung samples from animals with pulmonary artery banding surgery.

Pulmonary Hypoplasia Resulting from Pulmonary Artery Banding in Infancy: A Neonatal Rat Model Study.

The aim of this study was to establish a neonatal rat model of decreased pulmonary blood flow (PBF) for studying pulmonary pathophysiological changes in newborn lung development with reduced PBF. Horizontal thoracotomy surgery with banding of the main pulmonary artery (PA) was performed on 30 rats in the PA banding (PAB) group and without banding on another 30 rats in the sham group within 6 h after birth. The body growth and mortality were recorded.

Temperature dependent molecular fluorescence of [Ag] quantum clusters stabilized by phosphate glass networks.

Molecule like silver quantum clusters ([Agm]n+ QCs) exhibit an ultrasmall size confinement resulting in efficient broadband fluorescence. However, free [Agm]n+ QCs are also chemically active, so their stabilization is required for practical applications. We report in this work a phosphate oxyfluoride glass network enabled stabilization strategy of [Agm]n+ QCs.

Ultrastable Laurionite Spontaneously Encapsulates Reduced-dimensional Lead Halide Perovskites.

Reduced dimensional lead halide perovskites (RDPs) have attracted great research interest in diverse optical and optoelectronic fields. However, their poor stability is one of the most challenging obstacles prohibiting them from practical applications. Here, we reveal that ultrastable laurionite-type Pb(OH)Br can spontaneously encapsulate the RDPs in their formation solution without introducing any additional chemicals, forming RDP@Pb(OH)Br core-shell microparticles.

Structural Origins of RF/NaRF Nanocrystal Precipitation from Phase-Separated SiO-AlO-RF-NaF Glasses: A Molecular Dynamics Simulation Study.

Oxyfluoride glass-ceramics with RF or NaRF (R: rare earth elements) nanocrystals are considered as favorable hosts for luminescence applications. In this work, we utilized large-scale molecular dynamics (MD) simulations with effective partial charge potentials to study a series of oxyfluoride glasses that are of interest to the precipitation of RF or NaRF nanocrystals as previous experiment results suggested. The results show that phase separation exists in all glass compositions with fluoride-rich regions made up of R, Na, and F and oxide-rich regions consisting of aluminosilicate networks.

Photoswitchable probe with distinctive characteristics for selective fluorescence imaging and long-term tracing.

A photo-switchable and high-contrast bio-imaging indicator 4,4'-(1,1')-(4,4'-(cyclopentene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(methan-1-yl-1-ylidene)bis(azan-1-yl-1-ylidene)bis(2-(benzo[]thiazol-2-yl)phenol) (BMBT) has been demonstrated, by integrating photochromophore with excited-state intramolecular proton transfer (ESIPT) moiety. The ability of reversible emission switching enables arbitrarily selective labeling or concealing of cells simply by controlling light irradiation. Besides, when the emission was switched on, BMBT is demonstrated to exhibit unique characteristics of aggregation induced emission (AIE), providing a high on-off ratio for favorable bio-imaging.

Phase separation strategy to facilely form fluorescent [Ag]/[Ag] quantum clusters in boro-alumino-silicate multiphase glasses.

By adjusting the content of ZnF-SrF/ZnO-SrO, a series of SiO-AlO-BO-NaO-ZnO/ZnF-SrO/SrF-Ag multiphase glasses was designed and prepared via a melt-quenching method. Under a phase separation strategy, negatively charged tetrahedrons ([BO], [ZnO], and [AlO]) can be generated to stabilize different silver species (Ag ions; [Ag] pairs; [Ag] quantum clusters ([Ag] QCs)) in BO-rich and ZnO-AlO rich sub-phases. The BO-rich sub-phase has a high solubility for Ag ions and [Ag] QCs.

A Lipopeptide-Based αvβ₃ Integrin-Targeted Ultrasound Contrast Agent for Molecular Imaging of Tumor Angiogenesis.

The design and fabrication of targeted ultrasound contrast agents are key factors in the success of ultrasound molecular imaging applications. Here, we introduce a transformable αvβ3 integrin-targeted microbubble (MB) by incorporation of iRGD-lipopeptides into the MB membrane for non-invasive ultrasound imaging of tumor angiogenesis. First, the iRGD-lipopeptides were synthesized by conjugating iRGD peptides to distearoylphosphatidylethanolamine-polyethylene glycol 2000-maleimide.

[Value of dual-time-point (18)F-fluorodeoxyglucose integrated positron emission and computed tomography in differentiation of malignant from benign gastrointestinal diseases].

Objective: To explore the value of dual-time-point (18)F-fluorodeoxyglucose integrated positron emission and computed tomography ((18)F-FDG PET-CT) in differentiation of malignant from benign gastrointestinal diseases.

Methods: Sixty five patients with suspected gastrointestinal lesions underwent dual-time-point (18)F-FDG PET-CT imaging. Standardized uptake value (SUV) was calculated for semi-quantitative assessment.