Pneumonia Caused by and SARS-CoV-2 Coinfection Diagnosed Using Metagenomic Next-Generation Sequencing: A Case Report.

We report a case of pneumonia caused by coinfection with and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1 variant, confirmed using metagenomic next-generation sequencing (mNGS) and quantitative polymerase chain reaction (qPCR). and SARS-CoV-2 were detected in bronchoalveolar lavage fluid using mNGS.

Case Report: Pneumonia Caused by and Co-Infection.

This study presents a rare case of pneumonia caused by a co-infection of and , confirmed by metagenomic next-generation sequencing (mNGS). The patient, who had underlying chronic hepatitis B, had adopted a stray pigeon before the onset of the disease. The primary symptoms were fever, and a productive cough.

Long-non-coding RNA AK001058: A genetic biomarker in cisplatin sensitivity of non-small-cell lung carcinoma.

Previous evidences have shown that lncRNA AK001058 serves as an oncogene. This study aims to elucidate the expression characteristic of AK001058 in NSCLC samples, and its potential influence on the malignant progression and cisplatin resistance of NSCLC. Relative levels of AK001058 and IGF2 in NSCLC and non-tumoral tissues were detected by qRT-PCR.

Clinical characteristics of 14 cases of severe Chlamydia psittaci pneumonia diagnosed by metagenomic next-generation sequencing: A case series.

Introduction: The objective of this study was to explore the clinical, laboratory, and imaging features of severe Chlamydia psittaci pneumonia in order to improve early diagnosis and treatment success rates.

Methods: We conducted a retrospective record review of 14 cases of severe Chlamydia psittaci pneumonia diagnosed by metagenomic next-generation sequencing technology in our hospital. We extracted and analyzed data on the clinical symptoms and signs, contact history, laboratory investigations, chest computed tomography, treatment, and clinical outcomes.

Severe Pneumonia Complicated by Rhabdomyolysis: A Case Series.

Purpose: To explore the clinical characteristics, diagnosis, and treatment of severe pneumonia complicated by rhabdomyolysis and to improve the success rate of treatment.

Patients And Methods: The clinical characteristics, diagnosis, treatment, and outcomes of four patients with severe pneumonia complicated by rhabdomyolysis diagnosed by metagenomic next-generation sequencing (mNGS) in our hospital were analyzed retrospectively.

Results: All four patients were male, aged 46-64 years, and all had a history of bird contact.

[The change of fractalkine in lung tissue of rat with hypoxic pulmonary hypertension].

Objective: To evaluate the role of fractalkine in the pathogenesis of hypoxic pulmonary hypertension.

Methods: Twenty male SD rats were randomly divided into control group and hypoxic group. Rats in hypoxic group were exposed to hypoxia for 3 weeks.

[Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically].

Objective: To observe the role of simvasatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in synthesis and excretion of endothelin-1 (ET-1) in endothelial cell cultured hypoxically.

Methods: Human umbilical vein endothelial cells were hypoxically cultured and treated with simvastatin by different concentrations (0, 1.0, 2.

[The change of fractalkine in serum and pulmonary arterioles of hypoxic rat].

Objective: In order to evaluate the role of fractalkine in the pathogenesis of hypoxic pulmonary hypertension, we observed the change of serum soluble fractalkine and the expression of fractalkine in pulmonary arterioles of rat at different phase of hypoxia-induced pulmonary hypertension development.

Methods: The rat model of hypoxic pulmonary hypertension was duplicated by intermittent hypoxia. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization.

[Expression and clinical significance of matrilysin (MMP-7) in human rectal cancer].

Objective: To detect the matrilysin (MMP-7) expression in human rectal cancer and to investigate whether it is correlated with invasion and metastasis of human rectal cancer.

Methods: The paired samples obtained from 100 inpatients were allocated into cancer group and control group. By Quantitative-Real-Time RT-PCR, immunohistochemical staining and computerized image analysis, the mRNA and protein expressions of MMP-7 in human rectal cancer were measured and further analyzed for the relationship between MMP-7 expression and clinicopathologic characters.

[The change of nuclear factor-kappa B expression in the lung tissues of chronic hypoxic rats].

Objective: To investigate the change of nuclear factor-kappa B (NF-kappaB) expression in the lung tissues from chronic hypoxic rats and the role of NF-kappaB in the pathogenesis of hypoxic pulmonary hypertension.

Methods: Twenty male SD rats were randomly divided into two groups: control group and hypoxic group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for three weeks.

[Research on Rho-kinase expression in pulmonary arterioles of rat exposed to hypoxia].

Objective: To evaluate the expression and the role of Rho-kinase (ROCK I and ROCK II )in the development of hypoxic pulmonary hypertension of rat.

Methods: Thirty six of adult male SD rats were randomly divided into six groups; one group was exposed to air as normal control, the other five groups were exposed to isobaric hypoxia for 1 day, 3 days, 1 week, 2 weeks and 3 weeks respectively. Microtube method was used to measure the mean pulmonary arterial pressure (mPAP).

[Preventive effects of montelukast on the collagen expression of pulmonary arterioles in rats with chronic hypoxia].

Objective: To evaluate the preventive effects of montelukast on the collagen expression of pulmonary arterioles in chronic hypoxic rats.

Methods: Thirty male Wistar rats were randomly divided into three groups: control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions 8 hours q.

[Preventive effects of urapidil on hypoxic pulmonary hypertension in rats].

Objective: To investigate the preventive effect of urapidil, an alpha 1-adrenoceptor antagonist, on hypoxic pulmonary vascular remodeling.

Methods: Twenty-one male Sprague-Drawley rats were randomly allocated into three groups: control group, hypoxic group and hypoxic plus urapidil group. The animal model of hypoxic pulmonary hypertension was established by exposing the rats to normobaric hypoxic condition for three weeks, and the rats of hypoxic plus urapidil group were treated with urapidil 10 mg/kg before and after hypoxic processing.

[Preventive effects of montelukast on hypoxic pulmonary hypertension in rats].

Objective: To evaluate the role of cysteinyl leukotriene(CysLT) in the pathogenesis of hypoxic pulmonary hypertension and the preventive effects of montelukast, a CysLT receptor antagonist, on hypoxic pulmonary hypertension.

Methods: Thirty male Wistar rats were randomly divided into three groups: control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for 3 weeks.