Introduction: This study aims to investigate the role of the m6A regulatory factor METTL3 in LUAD.
Methods: By examining the expression of METTL3 in LUAD and conducting cellular functional experiments, the biological functions of METTL3 were discussed. mRNA-seq and MeRIP-qPCR were used to identify downstream target genes and pathways.
Pilot Free Trade Zones (PFTZs) are a crucial new platform for China to build a more open economic system. Existing literature primarily focuses on the 'Bring In' effect of PFTZs, often overlooking the importance of 'Going Out' aspects. To bridge this gap, this paper uses data from China's Shanghai and Shenzhen A-share listed enterprises from 2007 to 2021 and constructs a time-varying difference-in-differences (DID) model to test the impact of establishment of PFTZs on international expansion of enterprises.
View Article and Find Full Text PDFAims: To investigate alternative resistance mechanisms among seven ceftazidime-avibactam (CZA)-resistant carbapenem-resistant Klebsiella pneumoniae (CRKP) strains lacking common antimicrobial resistance genes (ARGs) using whole genome sequencing.
Methods And Results: ARG and virulence factors (VFs) were screened using the ARG database CARD and the VF database, respectively, and identified using genomic annotation data with BLAST+. Six strains were ST11 sequence types (STs), and one was ST2123.
Among malignant tumors, lung adenocarcinoma (LUAD) is the leading cause of death worldwide. This study explored the diagnostic, prognostic value, and preliminary functional verification of sialic acid binding Ig like lectin 17, pseudogene (SIGLEC17P) in LUAD. Prognostic lncRNAs for LUAD were identified by The Cancer Genome Atlas and quantitative real-time PCR (qRT-PCR) was used to detect the expression of SIGLEC17P in LUAD and paracarcinoma tissues.
View Article and Find Full Text PDFACS Appl Mater Interfaces
June 2022
In this study, we fabricate a new kind of ultrasensitive humidity-responsive photonic crystal (HPC) films based on emulsion polymerization and the open mill and bending-induced ordering technique (OM-BIOT) method, which is simple and scalable. The HPC film senses relative humidity (RH) from 9 to 98% for the polymer matrix swells up in high RH and shrinks in low RH, leading to a large reflectance shift (81 nm) and distinct color change. Based on the double-peak reflective spectra of the HPC film, we confirm the gradient swelling hypothesis and find that the thickness is another important factor for controlling the sensitivity and response rate of the HPC film.
View Article and Find Full Text PDFIn this paper, we report a facile strategy to combine magneto-responsive photonic crystal (MRPC) ink with 3D printing technology. The building blocks of MRPC are based on FeO magnetic nanoparticle clusters (MNCs) with uniform and tunable size. The MNC dispersion is able to change its photonic band gap from red to blue as the external magnetic field strength is increased.
View Article and Find Full Text PDFBackground: Lung cancer is the most prevalent and deadliest cancer worldwide. The present study aims to determine the prognosis value of low expression long non-coding RNAs (lncRNAs) in LUAD.
Methods: RNA-seq data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) data-base.
ACS Appl Mater Interfaces
September 2020
Usually, materials with perfect structures possess excellent properties, but it is not always the case. Here, a new approach is reported to construct structural colored hydrogel films with excellent ultraviolet (UV) blocking performance for contact lenses. The theoretical simulation predicts that with perfect periodic structures, the hydrogel films can strongly reflect incident light in a narrow visible wavelength range and thus exhibit extraordinarily brilliant colors.
View Article and Find Full Text PDFShape memory photonic crystals (SMPCs) combining the main characteristics of shape memory materials and photonic crystals have drawn increasing research interest. In sharp contrast to traditional responsive photonic crystals, the temporary shape of SMPCs can be "frozen" and photonic configurations can be modulated by temperature. However, the large-scale fabrication of SMPCs still remains a big challenge, making the practical application difficult.
View Article and Find Full Text PDFPhotonic crystals (PCs) are an important subset of photonic materials with specific optical properties, which can be utilized for structural color printing, anti-counterfeiting technologies, chemical sensors and so on. However, the fabrication of scalable, high-quality and uniform photonic crystal films at room temperature still remains a big challenge. Herein, a fast, energy efficient and scalable process is reported for the first time.
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