GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease.

Accumulation of insoluble deposits of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP) processing, represents one of the major pathological hallmarks of Alzheimer's disease (AD). Perturbations in APP transport and hydrolysis could lead to increased Aβ production. However, the precise mechanisms underlying APP transport remain elusive.

CSI-F: A Human Motion Recognition Method Based on Channel-State-Information Signal Feature Fusion.

The recognition of human activity is crucial as the Internet of Things (IoT) progresses toward future smart homes. Wi-Fi-based motion-recognition stands out due to its non-contact nature and widespread applicability. However, the channel state information (CSI) related to human movement in indoor environments changes with the direction of movement, which poses challenges for existing Wi-Fi movement-recognition methods.

Deficiency of the Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.

The axoneme and accessory structures of flagella are critical for sperm motility and male fertilization. Sperm production needs precise and highly ordered gene expression to initiate and sustain the many cellular processes that result in mature spermatozoa. Here, we identified a testis enriched gene transmembrane protein 232 (), which is essential for the structural integrity of the spermatozoa flagella axoneme.

RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.

RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis, but the targets and molecular functions of RBM46 remain unknown. Here, we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRNAs encoding multiple meiotic cohesin subunits and show that RBM46 is required for normal synaptonemal complex formation during meiosis initiation. Using a recently reported, high-resolution technique known as LACE-seq and working with low-input cells, we profiled the targets of RBM46 at single-nucleotide resolution in leptotene and zygotene stage gametes.

Quantitative Analysis of Berberidis Cortex via Quantitative Analysis of Multicomponents by Single Marker (QAMS) Combined with Fingerprint and Chemometrics Methods.

Berberidis Cortex is rich in alkaloids, and many of them have antibacterial, anti-inflammatory, and hypoglycemic activities. However, few research studies have focused on the quantitative analysis of multiple components from Berberidis Cortex. In this study, a new quality evaluation strategy for Berberidis Cortex was developed and validated by high-performance liquid chromatography (HPLC), which involved single marker, fingerprint, and stoichiometric methods.

[Characteristics of Mercury Emissions from Modern Dry Processing Cement Plants in Chongqing].

Three typical modern dry processing cement plants in Chongqing were chosen to investigate mercury emission characteristics and its source and fate through a mercury mass balance method by analyzing mercury contents in all input and output materials. The results showed that limestone was the main source of mercury in three cement plants followed by coal, and their mercury concentrations were (0.025±0.

[Characteristics of Mercury Emissions from Coal-fired Power Plants in Chongqing].

Four typical coal-fired power plants in Chongqing, representing two different boiler types (circulating fluidized bed boiler and pulverized coal boiler), were chosen to investigate mercury emission characteristics through a mercury mass balance method by analyzing mercury contents in all input and output raw materials in order to accurately estimate mercury emissions. The results showed coal with mercury concentrations ranging (80.77±6.

Acupuncture for Smoking Cessation in Hong Kong: A Prospective Multicenter Observational Study.

This was a prospective multicenter observational study, aiming to explore the effects of acupuncture on smoking cessation in Hong Kong. From March of 2010 to August of 2015, a total of 5202 smokers were recruited based on inclusion criteria and treated with acupuncture for 8 weeks. As a result, 2940 subjects finished the study with a drop-out rate of 43.

Effect of acupuncture treatment on smoking cessation in smokers from Hong Kong.

Objective: To analyze the characteristics of smokers treated with acupuncture for smoking cessation in Hong Kong.

Methods: A total of 2051 subjects were recruited in a clinical pilot research project "acupuncture for smoking cessation", which was conducted jointly by Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences and Hong Kong Pok Oi Hospital from January of 2011 to December of 2013. The characteristics of study subjects, including baseline information, smoking background, intention to quit and influencing factors were analyzed.

Predictors for Smoking Cessation with Acupuncture in a Hong Kong Population.

Background. Observational studies of smoking cessation with acupuncture have been reported widely; however, few researchers have focused on its predictors. Objective.

Predicting future blood demand from thalassemia major patients in Hong Kong.

Background: In Hong Kong, thalassemia major (TM) patients utilized up to 9.5% of blood supply in 2009. For long-term management of blood supply, we predicted the future blood demand of TM patients for the next 10 years.