Development and reliability and validity testing of a medication literacy scale for medical college students.

Background: Irrational drug use has become a global problem threatening human health. As future health professionals, medical college students' medication literacy (ML) is critical. Their mastery of medication-related knowledge will directly affect public medication safety in the future.

The activity level of follicular helper T cells in the peripheral blood of osteosarcoma patients is associated with poor prognosis.

Osteosarcoma (OS) is solid tumors with high malignancy and incidence starting in the bones. OS pathogenesis has been proved to be closely associated with immune imbalance, and follicular helper T cells (Tfh) significantly affect host humoral immune homeostasis. However, there are few reports on the effect of Tfh cell activation on the prognosis of OS patients.

miR-138 Reduces the Dysfunction of T Follicular Helper Cells in Osteosarcoma via the PI3K/Akt/mTOR Pathway by Targeting PDK1.

Objective: To study the effect of miR-138 on the function of osteosarcoma (OS) T follicular helper cells (Tfh cells) and its mechanism.

Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from patients with osteosarcoma (OS group) and healthy volunteers (control group). CD4+CXCR5+ Tfh cells and CD9+ B cells were sorted by flow cytometry.