Discovery of -Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides.

A series of -aryl-pyridine-4-one derivatives were designed and synthesized using maltol and antidesmone as lead compounds, and then their fungicidal/bactericidal activities and possible mechanism of action against were explored. Most of these compounds exhibited significant fungicidal activity . Especially, compound has more than 90% inhibitory activity against nine plant pathogenic fungi at 50 μg mL, which is superior to azoxystrobin.