Publications by authors named "Xiumin Xue"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis, and deguelin, derived from an African plant, shows potential as a treatment option.
- Research indicates that deguelin reduces the survival of GBM cells by blocking their progression in the cell cycle and inducing cell death, while also preventing their movement (migration).
- Key findings suggest that deguelin decreases the levels of the chemokine CCL2, which influences tumor growth and the tumor microenvironment by affecting the NFκB signaling pathway, indicating a possible new approach for GBM therapy.
Article Synopsis
- * Tryptanthrin has shown potential in reducing inflammation by promoting microglia to switch from the neurotoxic M1 state to the protective M2 state via the cGAS/STING/NF-κB pathway.
- * In mouse models, tryptanthrin not only improved microglial polarization but also reduced neuron loss, aided tissue repair, and enhanced functional recovery following spinal cord injury.
Glioblastoma (GBM) is the most common malignant glioma among brain tumors with low survival rate and high recurrence rate. Columbianadin (CBN) has pharmacological properties such as anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. However, it remains unknown that the effect of CBN on GBM cells and its underlying molecular mechanisms.
View Article and Find Full Text PDFMost chemotherapeutic drugs are potent and have a very narrow range of dose safety and efficacy, most of which can cause many side effects. Chemotherapy-induced peripheral neuropathy (CIPN) is the most common and serious side effect of chemotherapy for cancer treatment. However, its mechanism of action is yet to be fully elucidated.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most prevalent type of adult primary brain tumor and chemotherapy of GBM was limited by drug-resistance. Fraxinellone is a tetrahydro-benzofuranone derivative with various pharmacological activities. However, the pharmacological effects of fraxinellone on GBM remains largely unknown.
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