Publications by authors named "Xiumei Xiong"
Article Synopsis
- Anti-CTLA-4 antibodies encountered issues like frequent side effects and limited effectiveness, prompting research into advanced CTLA-4 therapies that better deplete regulatory T cells while activating CD8 T cells.
- CCR8, primarily found on tumor-infiltrating Tregs, emerged as a significant target due to its ability to promote anti-tumor responses through Treg depletion.
- The newly developed bispecific antibody 2MW4691 selectively targets CCR8 and CTLA-4, enhancing T cell activation and selectively depleting Tregs, demonstrating promising in vitro and in vivo efficacy with minimal side effects, warranting further clinical trials.
Article Synopsis
- * In a study reviewing cases from 2013 to 2020, 72.5% of HP patients were accurately diagnosed using transvaginal ultrasonography, and the presence of cardiac activity in the IUP significantly correlated with better live birth rates.
- * The findings emphasize the need for early detection and surgical intervention in HP cases to reduce complications, like miscarriage, suggesting that an IUP with cardiac activity during diagnosis is a positive indicator of potential live birth.
Article Synopsis
- - This study investigates genetic risk factors linked to abnormal uterine bleeding following the insertion of a copper intrauterine device (IUD) using whole-exome sequencing and validation through Sequenom MassARRAY.
- - Eight genetic variants were identified that could potentially cause clinical issues, with two specific variants (p.Ile971Met and p.Gly365Ser) showing a strong correlation with abnormal uterine bleeding.
- - The results suggest these genetic variants may influence bleeding by affecting blood clotting and inflammation in the uterine lining, offering a foundation for personalized approaches in IUD implantation.
Aim: Intrauterine device (IUD) is a commonly used contraceptive method worldwide. Abnormal uterine bleeding (AUB) is one of the most common side effects of Cu-IUDs. Since AUB varies among Cu-IUD users, changes in the bleeding-related genetic factors may contribute to AUB.
View Article and Find Full Text PDFObjective: To investigate changes in the level of protein in serum and uncover the underlying pathogenesis of abnormal uterine bleeding (AUB) associated with copper intrauterine devices (Cu IUD).
Methods: Protein profiles were investigated via tandem mass tag (TMT)-based quantitative proteomics and bioinformatics technology. Quantification and characterization of candidate proteins were further performed in 33 controls and 45 cases by Luminex assay and enzyme-linked immunosorbent assay.
Built on 2 existing classification systems, this study was to develop a new classification system to better predict the pregnancy prognosis after laparoscopic surgery in patients with tubal factor infertility and accordingly propose a management strategy.We followed up 423 patients suffering from tubal factor infertility who had undergone hysteroscopic-laparoscopic surgery for 2 years without in vitro fertilization and embryo transfer (IVF/ET). Based on the operative reports, a new, modified classification of fallopian tube status (hereafter referred to as the modified classification) was developed with reference to the 2 existing classification systems (the r-AFS classification of pelvic adhesions and the scoring system of distal tubal obstruction).
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