Publications by authors named "Xiulong Jiang"
Article Synopsis
- - Glioma is a common and aggressive brain tumor linked to poor patient outcomes, and this study investigates the role of the CNOT7 protein, which has not been previously reported in this context.
- - Using data from various cancer databases and a series of cellular function experiments, the researchers found that high levels of CNOT7 correlated with worse prognosis and that reducing CNOT7 expression led to decreased glioma cell growth and spread.
- - The study reveals that CNOT7 influences glioma development through specific molecular pathways and is regulated by the HDAC2 protein, suggesting it may serve as a potential therapeutic target or biomarker for glioma.
The combination of crystallization, transparency, and strength is still a challenge for broadening the application of polylactic acid (PLA) films, while it is also difficult to balance. In this work, the long aliphatic chains of octadecylamine (ODA) were grafted onto the surface of cellulose nanocrystal (CNC) by tannic acid oxidation self-polymerization and Michael addition/Schiff base reaction between polytannic acid and ODA. Furthermore, the ODA grafted CNC (g-CNC) was used as green reinforcement for the PLA matrix and a series of PLA/g-CNC nanocomposite films were prepared by the casting method.
View Article and Find Full Text PDFAngiogenesis after ischemic stroke contributes to the restoration of blood supply in the ischemic zone. Strategies to improve angiogenesis may facilitate the function recovery after stroke. Growing evidence shows that proteasome inhibitors enhance angioneurogenesis and induces a long-term neuroprotection after cerebral ischemia in rodents' models.
View Article and Find Full Text PDFThe study was performed to investigate the role of sonic hedgehog (SHH) in the oxidized low-density lipoprotein (oxLDL)-induced blood-brain barrier (BBB) disruption. The primary mouse brain microvascular endothelial cells (MBMECs) were exposed to oxLDL. The results indicated that treatment of MBMECs with oxLDL decreased the cell viability, and oxidative stress was involved in oxLDL-induce MBMECs dysfunction with increasing intracellular ROS and MDA formation as well as decreasing NO release and eNOS mRNA expression.
View Article and Find Full Text PDFObjective: Determining the prognoses of patients with acute ischemic stroke is difficult. Therefore, the aim of this study was to evaluate whether the combined assessment of plasma N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and the National Institutes of Health Stroke Scale (NIHSS) variables is relevant to the prognosis of patients with acute cerebral ischemic infarction in-hospital.
Methods: We enrolled 122 patients who were within three days of onset of acute ischemic stroke.