Optimized rAAV8 targeting acinar KLF4 ameliorates fibrosis in chronic pancreatitis via exosomes-enriched let-7s suppressing pancreatic stellate cells activation.

Chronic pancreatitis (CP) is marked by progressive fibrosis and the activation of pancreatic stellate cells (PSCs), accompanied by the destruction of pancreatic parenchyma, leading to the loss of acinar cells (ACs). Few research studies have explored the mechanism by which damaged ACs (DACs) contribute to PSCs activation and pancreatic fibrosis. Currently, there are no effective drugs for curing CP or limiting the progression of pancreatic fibrosis.

Mechanical properties analysis of medical endodontic instruments based on parameterization.

To study the relationship between structural parameters and mechanical properties of endodontic instruments, the T02004B25 nickel-titanium endodontic instrument was selected for bending and torsion tests and finite element simulation analysis, which demonstrated the feasibility of simulation analysis method. Then based on the idea of parametric design, the models of the endodontic instruments with different structural parameters (cross-section, pitch, taper) were established, and the bending-torsion performance simulation analysis was completed. The results showed that the mechanical properties of endodontic instruments with different structural parameters are different.

A comparative investigation between particle oxidation catalyst (POC) and diesel particulate filter (DPF) coupling aftertreatment system on emission reduction of a non-road diesel engine.

Non-road emission regulations are becoming increasingly rigorous, which makes it necessary for non-road engines to adopt aftertreatment systems. The commonly used aftertreatments mainly include diesel oxidation catalytic (DOC), diesel particulate filter (DPF), particle oxidation catalyst (POC), selective catalytic reduction (SCR) and ammonia purification catalyst (ASC). The purpose of this study is to investigate the effects of using an integrated system (DOC + DPF/POC + SCR + ASC) on non-road diesel engine emissions under steady-state and transient operating conditions, respectively.