Publications by authors named "Xiulian Jin"
Mitophagy is thought to play an important role in mitochondrial quality control. Mitochondrial division is believed to occur first, and autophagosome formation subsequently occurs to enwrap mitochondria as a process of mitophagy. However, there has not been any temporal analysis of mitochondrial division and autophagosome formation in mitophagy.
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- In the study, scientists looked at how cells break down damaged mitochondria during stress using special colorful proteins to see the process called mitophagy.
- They found that this breakdown doesn't happen much with a common chemical but does happen a little when cells are starved or low on oxygen.
- The researchers also discovered that certain proteins are needed for this process, showing that a different method, not the usual one, is mostly used for mitophagy in these cells.
When mitophagy is induced in Saccharomyces cerevisiae, the mitochondrial outer membrane protein ScAtg32 interacts with the cytosolic adaptor protein ScAtg11. ScAtg11 then delivers the mitochondria to the pre-autophagosomal structure for autophagic degradation. Despite the importance of ScAtg32 for mitophagy, the expression and functional regulation of ScAtg32 are poorly understood.
View Article and Find Full Text PDFMitophagy is a process that selectively degrades mitochondria. When mitophagy is induced in yeast, the mitochondrial outer membrane protein Atg32 is phosphorylated, interacts with the adaptor protein Atg11 and is recruited into the vacuole with mitochondria. We screened kinase-deleted yeast strains and found that CK2 is essential for Atg32 phosphorylation, Atg32-Atg11 interaction and mitophagy.
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