Publications by authors named "Xiuli Zhang"

Article Synopsis
  • The study compares the accuracy of nine different methods for estimating the one-repetition maximum (1RM) of back squats using velocity data from resistance-trained male subjects.
  • Two types of testing sessions were conducted: one using six different loads and another with just two loads to derive minimal velocity thresholds (MVTs) for more accurate predictions.
  • The findings suggest that the most precise 1RM estimates came from using the optimal MVT with a 2-point method, resulting in errors under 4%, making this approach recommended for accurate free-weight back squat assessments.
View Article and Find Full Text PDF

Colorectal cancer remains a formidable global health challenge, characterized by high recurrence rates and poor prognosis. This study introduces a novel Recurrence Related Gene Signature (RRGS), designed to predict therapy response and enhance prognostic accuracy in colorectal cancer. Through analysis of the GSE17536 cohort, we identified 79 differentially expressed genes (DEGs) between recurrent and non-recurrent cases, comprising 54 upregulated and 25 downregulated genes.

View Article and Find Full Text PDF

In recent years, slippery liquid infused porous surfaces (SLIPS) renowned for their exceptional liquid repellency and anti-fouling properties, have garnered considerable attention. However, the instability of both structural integrity and the oil film severely restricts their practical applications. This study is inspired by superwetting biological surfaces, such as fish scales, seashells, and Nepenthes, to design and fabricate a multiplex biomimetic and robust lubricant-infused textured surface (LITMS) using laser-coating composite processing technology.

View Article and Find Full Text PDF

Background: We assessed the correlation between optic nerve sheath diameter (ONSD) values measured by bedside ultrasound and intracranial pressure (ICP) changes among patients under neurocritical care and evaluated the diagnostic performance of ONSD for increased ICP.

Methods: Sixty-seven neurologically critical patients who were hospitalised in the intensive care unit (ICU) of Jining No.1 People's Hospital between September 2023 and March 2024 and underwent lumbar puncture were included.

View Article and Find Full Text PDF

We have previously found that the DAPK-DDX20 signaling axis exerts an anti-cancer activity in hepatocellular carcinoma (HCC) by inhibiting the GTPase activity of CDC42, thereby reducing the invasive and migratory capabilities of cancer cells without affecting cell proliferation. DDX20 serves as an intermediate protein regulated by DAPK in the control of CDC42. Specifically, DAPK enhances DDX20 protein levels by suppressing DDX20 degradation.

View Article and Find Full Text PDF

Background: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes and performed a phase 1 clinical trial in triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy, a patient population at high risk of disease recurrence.

Methods: Expressed somatic mutations were identified by tumor/normal exome sequencing and tumor RNA sequencing.

View Article and Find Full Text PDF

Hand compartment syndrome is a rare condition due to trauma and vascular obstruction or injury, such as fluid extravasation, vascular obstruction, or arterial injury from arterial line insertion during anesthesia. However, perioperative hand compartment syndrome with no apparent preexisting cause during anesthesia that requires fasciotomy is extremely rare. We report a case on a 54-year-old male with history significant for stage IIIA moderately differentiated adenocarcinoma of the rectum who was scheduled for ultralow rectal resection and cystourethroscopy with insertion of urethral stent.

View Article and Find Full Text PDF

The incidence of infection is on the rise; however, the existing drug treatment cycle is lengthy and often requires multi-drug combination. Therefore, there is a need to develop new and effective anti- drugs. Cochliomycin A, a 14-membered resorcylic acid lactone with an acetonide group at C-5' and C-6', exhibits a wide range of antimicrobial, antimalarial, and antifouling activities.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored the connection between immune traits and different types of pancreatitis using a method called Mendelian randomization.
  • Researchers collected data on 731 immune traits and linked that to findings on acute and chronic pancreatitis from large databases, confirming results through various analysis methods.
  • They found 36 immune traits associated with pancreatitis risk, highlighting specific immune cells that may serve as potential targets for future treatments and interventions.
View Article and Find Full Text PDF
Article Synopsis
  • - Wind speed significantly influences wind erosion and dust emissions, particularly in arid and semiarid areas, making accurate hourly wind simulations vital for effective land management! - The study tested the Wind Erosion Prediction System (WEPS) model in the Inland Pacific Northwest, where it struggled to accurately simulate hourly wind speeds at half of the meteorological stations due to factors like topography and spatial interpolation! - Validation efforts showed that when spatial interpolation was minimized, the WEPS model performed better, indicating it can be reliable for assessing wind erosion if users account for potential underestimations of wind speed!
View Article and Find Full Text PDF

Developing low-cost catalysts with high activity for the Hydrogen Evolution Reaction (HER) is a main challenge to reduce the dependence on precious metals while maintaining the catalytic activity. In this study, nickel-plated multi-walled carbon nanotubes (Ni-MWCNTs) with a large number of active sites were selected, and Ni-MWCNTs electrocatalysts loaded with trace amounts of RuO nanoparticles were prepared by annealing treatment, which exhibited excellent HER performances in both acidic and alkaline media. The RuO nanoparticles loaded nickel-coated multi-walled carbon nanotubes (RuO@Ni-MWCNTs) had a small electrochemical impedance spectrum (EIS) and a large electrochemically active surface area (ECSA).

View Article and Find Full Text PDF

Oocytes and early embryos are exposed to many uncontrollable factors that trigger endoplasmic reticulum (ER) stress during in vitro culture. Prevention of ER stress is an effective way to improve the oocyte maturation rate and oocyte quality. Increasing evidence suggests that dietary intake of sufficient n-3 polyunsaturated fatty acids (PUFAs) is associated with health benefits, particularly in the domain of female reproductive health.

View Article and Find Full Text PDF

Gastrodin, a highly potent compound found in the traditional Chinese medicine Blume, exhibits significant antihypertensive properties. However, its role and the mechanism behind its protective effects on hypertensive cardiac conditions are not well understood. This study aims to investigate the cardiac protective effects and underlying mechanisms of gastrodin in angiotensin II (Ang II)-induced hypertensive models, both in vivo and in vitro.

View Article and Find Full Text PDF

Background: Immune checkpoint inhibitor (ICI) usage has resulted in immune-related adverse events in patients with cancer, such as accelerated atherosclerosis. Of immune cells involved in atherosclerosis, the role of CCR2+ (CC motif chemokine receptor 2-positive) proinflammatory macrophages is well documented. However, there is no noninvasive approach to determine the changes of these cells in vivo following ICI treatment and explore the underlying mechanisms of immune-related adverse events.

View Article and Find Full Text PDF

Introduction: Observational studies have suggested associations between Brugada syndrome (BrS) and electrocardiograms traits. Nonetheless, the causal relationships remains uncertain in observational studies. This study aims to investigate the causal relationships between BrS phenotypic risk and electrocardiogram traits using Mendelian randomization (MR) analysis and colocalization analysis.

View Article and Find Full Text PDF

The widespread application of neonicotinoid insecticides (NNIs) has attracted widespread attention to their potential ecotoxicological effects. In this study, we systematically evaluated the toxic effects of thiamethoxam (TMX) and its metabolite clothianidin (CLO) on earthworms (Eisenia fetida). Specifically, the antioxidant system responses and endogenous metabolite metabolism responses in earthworms were analyzed in the temporal dimension after 7, 14, 21 and 28 days of exposure to TMX and CLO.

View Article and Find Full Text PDF

Introduction And Objective: His bundle pacing (HBP) could replace failed biventricular pacing (BVP) in guidelines (IIa Indication), but the high capture thresholds and backup lead pacing requirements limit its development. We assessed the efficacy and safety of HBP combined with atrioventricular node ablation (AVNA) for atrial fibrillation (AF) and compared with BVP and left bundle branch pacing (LBBP).

Methods: We reviewed PubMed, Embase, Web of Science, and Cochrane Library databases on left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) score, QRS duration (QRSd), and pacing threshold.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates a new training method that combines rapid stretch compound training with blood flow restriction to improve upper limb performance in basketball players.
  • A randomized crossover trial with ten male athletes was conducted, measuring the effectiveness of four different training interventions on their bench press throw.
  • The results show that the combined method produced significantly better post-activation performance enhancements at 4 minutes post-intervention compared to the other methods and maintained some effects up to 12 minutes, indicating its potential superiority for athletes.
View Article and Find Full Text PDF

Introduction: Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disease of the intestine. The intestinal microbiota is essential in the occurrence and development of UC. Gut gases are produced via bacterial fermentation or chemical interactions, which can reveal altered intestinal microbiota, abnormal cellular metabolism, and inflammation responses.

View Article and Find Full Text PDF

Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor 2 (CCR2) is specifically expressed on inflammatory populations of monocytes and macrophages that contribute to the development and progression of heart failure. Here, we evaluated a peptide-based imaging probe (Cu-DOTA-ECL1i) that specifically recognizes CCR2 monocytes and macrophages for human cardiac imaging. Compared to healthy controls, Cu-DOTA-ECL1i heart uptake was increased in subjects following acute myocardial infarction, predominately localized within the infarct area, and was associated with impaired myocardial wall motion.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists found a new way to build special chemical compounds called 3-alkylated quinoxalin-2(1)-ones using certain ingredients like alkyl carboxylic acids and alkyl iodides.
  • This method is practical, cost-effective, and works well with different types of these ingredients.
  • They discovered that a special catalyst called cobaloxime helps create tiny carbon fragments from the ingredients, making the process easier.
View Article and Find Full Text PDF

Drug-induced liver injury is a prevalent adverse event associated with pharmaceutical agents. More significantly, there are certain drugs that present severe hepatotoxicity only during the clinical phase, consequently leading to the termination of drug development during clinical trials or the withdrawal from the market after approval. The establishment of an evaluation model that can sensitively manifest such hepatotoxicity has always been a challenging aspect in drug development.

View Article and Find Full Text PDF
Article Synopsis
  • Lipids are essential for growth and reproduction, and urine-derived extracellular vesicles (EVs) are being studied as potential biomarkers for tuberculosis (TB) due to their non-invasive nature and lipid content.
  • Researchers isolated urine-derived EVs from 41 participants (including healthy individuals and those with TB) to analyze their lipid profiles and identify biomarkers using advanced statistical methods.
  • The study found 226 lipids, identifying 7 potential lipid biomarkers for TB and 6 for latent TB, with one promising biomarker, free fatty acid (FFA 20:1), showing high diagnostic performance in distinguishing TB from latent TB infection.
View Article and Find Full Text PDF

Synopsis of recent research by authors named "Xiuli Zhang"

  • - Xiuli Zhang's recent research encompasses a diverse range of topics, including the synthesis of marine-derived compounds with antimicrobial properties, the impact of immune features on pancreatitis, and the effects of neonicotinoid insecticides on soil organisms.
  • - Key findings indicate that Cochliomycin A exhibits promising antimicrobial activities, elucidating its potential as a novel anti-infective drug, while a Mendelian randomization analysis reveals significant causal relationships between immune traits and various forms of pancreatitis.
  • - Zhang's studies also highlight advancements in environmental science, demonstrating the effectiveness of the Wind Erosion Prediction System in predicting wind erosion dynamics, alongside pioneering work on the synthesis of nickel-coated carbon nanotube catalysts for hydrogen evolution reaction, emphasizing the promise of sustainable energy technologies.