Publications by authors named "Xiuli Su"

Triclocarban (TCC) is an extensively used antimicrobial agent that exhibits endocrine disrupt potential, but its effects on fetal growth remain largely unknown. Herein, we measured TCC, its four hydroxylated metabolites and two dechlorination products, as well as the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in maternal urine samples collected across three trimesters of pregnancy in Wuhan, China. Linear mixed-effect models and multiple linear regression models were applied for correlation analysis.

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F53B (6:2 chlorinated polyfluorinated ether sulfonate), a substitute for perfluorooctane sulfonate (PFOS), is widely used as a chromium mist inhibitor in the electroplating industry. However, significant concern has arisen owing to its biological toxicity. Several studies on F53B toxicity in mammals have focused on hepatotoxicity, immunotoxicity, developmental toxicity, and reproductive toxicity, while its neurotoxic effects, especially in relation to neurodegenerative diseases such as Parkinson's disease (PD), remain unclear.

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Introduction: Type 2 diabetes (T2D) is a heterogeneous metabolic disease with large variations in the relative contributions of insulin resistance and β-cell dysfunction across different glucose tolerance subgroups and ethnicities. A more precise yet feasible approach to categorize risk preceding T2D onset is urgently needed. This study aimed to identify potential metabolic biomarkers that could contribute to the development of T2D and investigate whether their impact on T2D is mediated through insulin resistance and β-cell dysfunction.

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Article Synopsis
  • SARS-CoV-2 is evolving rapidly through mutations, making it challenging to predict the severity of new variants and their ability to evade immunity.
  • Key molecules involved in polyamine biosynthesis were identified as potential markers for assessing the pathogenicity of these variants, particularly after comparing host responses at the proteome and metabolome levels.
  • The study suggests that these biomarkers could serve as useful tools for evaluating the virulence of existing and future SARS-CoV-2 variants, based on findings from human airway organoid models.
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Cadmium (Cd) pollution reduces rice production and quality, putting food security and human health at risk. We conducted comparative physiology and metabolomic analyses in two indica rice ('NH199' and 'NH224') to elucidate the Cd-tolerance mechanism. Cd hampered rice growth, induced oxidative stress, and changed the metabolomics profiling of the root.

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Background: Bioactive lipids play an important role in insulin secretion and sensitivity, contributing to the pathophysiology of type 2 diabetes (T2D). This study aimed to identify novel lipid species associated with incident T2D in a nested case-control study within a long-term prospective Chinese community-based cohort with a median follow-up of ~ 16 years.

Methods: Plasma samples from 196 incident T2D cases and 196 age- and sex-matched non-T2D controls recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) were first analyzed using untargeted lipidomics.

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  • Plastic pollution, particularly nanoplastics (NPs), poses a growing threat to human health, with their toxic effects still largely unknown.
  • This study examined the impact of 80 nm NPs on mitochondrial functions in human liver (L02) and lung (BEAS-2B) cells, finding that NPs can enter cells without causing mass death but lead to mitochondrial damage.
  • Results indicated significant metabolic disturbances, especially in liver cells, at low NP concentrations, highlighting potential risks of NPs in the environment and their effects on human health.
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Objective: Based on the acoustoelectric (AE) effect, transcranial acoustoelectric brain imaging (tABI) is of potential for brain functional imaging with high temporal and spatial resolution. With nonlinear and non-steady-state, brain electrical signal is microvolt level which makes the development of tABI more difficult. This study demonstrates for the first time in vivo tABI of different steady-state visual stimulation paradigms.

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Metabolites of methionine cycle, urea cycle and polyamine metabolism play important roles in regulating the metabolic processes and the development of diseases. It is rewarding and interesting to monitor the levels of the above metabolites in biological matrices to investigate pathological mechanisms. However, their quantitation is still unsatisfactory due to the poor retention behavior of the analytes on the traditional reversed-phase column.

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Genetic engineering (GE) technology is widely used in plant modification. However, the results of modification may not exactly meet the expectations. Herein, we propose a new multi-omics method for GE plant evaluation based on the optimized use of the metID algorithm.

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Article Synopsis
  • Lour. is a plant native to tropical Southeast Asia known for its medicinal properties, but its phytochemical analysis has been limited.
  • Researchers isolated three amide alkaloids from the plant's fruits: one new alkaloid, wuchuyuamide V, and two known alkaloids, wuchuyuamide III and wuchuyuamide I.
  • The structures of wuchuyuamide V and wuchuyuamide III were confirmed using advanced techniques like NMR spectroscopy, mass spectrometry, and X-ray diffraction.
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  • The study focused on isolating and analyzing quinazoline alkaloids from the unripe fruit of Evodia rutaecarpa, highlighting their diverse biological functions.
  • Three new alkaloids, evodiamide A, B, and C, were discovered along with eight previously known quinazolines in the methanol extract.
  • The compound rhetsinine was particularly noted for its strong pesticide potential, showing effective inhibition against several harmful bacteria with specific EC values.
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The Li-O battery is receiving much recent attention because of its superhigh theoretical energy density. However, its performance is limited by the irreversible formation/decomposition of LiO on the cathode and the undesired electrolyte decomposition. In this work, low-cost three-dimensional ordered macroporous (3DOM) FePO is synthesized by using polystyrene (PS) spheres template in a facile experimental condition and applied as a high-efficiency catalyst for rechargeable Li-O batteries, including good rate performance, high specific capacity, and perfect cycling stability.

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A flexible and wearable aqueous lithium-ion battery is introduced based on spinel Li1.1 Mn2 O4 cathode and a carbon-coated NASICON-type LiTi2 (PO4 )3 anode (NASICON=sodium-ion super ionic conductor). Energy densities of 63 Wh kg(-1) or 124 mWh cm(-3) and power densities of 3 275 W kg(-1) or 11.

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Objective: To investigate the efficacy of all-trans retinoic acid (ATRA) in human gastric dysplasia.

Methods: In this double-blind study, patients with precancerous gastric dysplasia with or without intestinal metaplasia (IM) received either conventional treatment consisting of omeprazole and sucralfate (control group) or conventional treatment plus ATRA. Gastric mucosal biopsies were performed before and after drug treatment and were analysed histologically; expression of retinoblastoma (Rb) protein and HER2 protein in gastric mucosa were measured using immunohistochemistry.

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Background: Previous studies investigating the association between TP53 Arg72Pro polymorphism and gastric cancer (GC) risk in Asian population have reported controversial results. Thus, a meta-analysis was performed.

Methods: A comprehensive literature search was conducted and 17 case-control studies were finally included, involving a total of 5,990 GC cases and 6,812 controls.

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Thin antimony oxide covered AuSb alloy electrode was firstly found to be an excellent cold cathode for generating hot electrons during cathodic pulse polarization. Owing to the injection of hot electrons and the subsequent generation of hydrated electrons, fluorescein iso-thiocyanate (FITC) that cannot be excited in common ECL was cathodically excited at the alloy electrode. Self-assembled thiol monolayers were formed on the electrode surface due to the presence of Au in the alloy, to which strepavidin was covalently bound, and then biotinylated antibody was immobilized through the strepavidin-biotin interaction.

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Cathodic electrochemiluminescence (ECL) is firstly observed at a carbon oxide covered glassy carbon (C/C(x)O(1-x)) electrode as a large cathodic pulse polarization is applied. This insulating carbon oxide (C(x)O(1-x)) film is constructed on a glassy carbon (GC) substrate by electrochemical oxidization in basic media. The film properties, such as the composition of carbon and oxygen, and the thickness as well, can be controlled by the potential and the duration in the oxidizing process.

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Electrochemical and electrogenerated chemiluminescence (ECL) properties of a glassy carbon electrode modified with CdS nanotubes (CdS-GCE) are investigated in neutral media. The cyclic voltammogram (CV) shows two cathodic peaks (P(C1) and P(C2)) at -0.76 and -0.

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