Adaptive Blind Super-Resolution Network for Spatial-Specific and Spatial-Agnostic Degradations.

Prior methodologies have disregarded the diversities among distinct degradation types during image reconstruction, employing a uniform network model to handle multiple deteriorations. Nevertheless, we discover that prevalent degradation modalities, including sampling, blurring, and noise, can be roughly categorized into two classes. We classify the first class as spatial-agnostic dominant degradations, less affected by regional changes in image space, such as downsampling and noise degradation.

Molecular and transcriptional basis of bidirectional CD4 T cell exhaustion in oropharyngeal squamous cell carcinoma.

Tumor-infiltrating CD4 T cells orchestrate the adaptive immune response through remarkable plasticity, and the expression patterns of exhaustion-related inhibitory receptors in these cells differ significantly from those of CD8 T cells. Thus, a better understanding of the molecular basis of CD4 T cell exhaustion and their responses to immune checkpoint blockade (ICB) is required. Here, we integrated multiomics approaches to define the phenotypic and molecular profiles of exhausted CD4 T cells in oropharyngeal squamous cell carcinoma (OPSCC).

The diversity of inhibitory receptor co-expression patterns of exhausted CD8 T cells in oropharyngeal carcinoma.

Exhausted CD8 T cells (Texs) are characterized by the expression of various inhibitory receptors (IRs), whereas the functional attributes of these co-expressed IRs remain limited. Here, we systematically characterized the diversity of IR co-expression patterns in Texs from both human oropharyngeal squamous cell carcinoma (OPSCC) tissues and syngeneic OPSCC model. Nearly 60% of the Texs population co-expressed two or more IRs, and the number of co-expressed IRs was positively associated with superior exhaustion and cytotoxicity phenotypes.

mRNA-LNP vaccination-based immunotherapy augments CD8 T cell responses against HPV-positive oropharyngeal cancer.

Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how they drive the functional commitment of CD8 T cells in tumor microenvironment (TME) and secondary lymphoid organs hinders their broader application in cancer immunotherapy. Here, we systematically evaluated the immunological effects of a lipid nanoparticle (LNP)-encapsulated mRNA vaccine that encodes human papillomavirus E7 protein (HPV mRNA-LNP), a tumor-specific antigen of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). HPV mRNA-LNP vaccination activated overall and HPV-specific CD8 T cells, as well as differentially drove the functional commitment of CD8 T cells through distinct IFN-response and exhaustion trajectories in the spleen and TME, respectively.

Integrated single-cell RNA-seq analysis reveals the vital cell types and dynamic development signature of atherosclerosis.

In the development of atherosclerosis, the remodeling of blood vessels is a key process involving plaque formation and rupture. So far, most reports mainly believe that macrophages, smooth muscle cells, and endothelial cells located at the intima and media of artery play the key role in this process. Few studies had focused on whether fibroblasts located at adventitia are involved in regulating disease process.

Proliferative exhausted CD8 T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma.

The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8 T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified.

Prognostic effects of previous cancer history on patients with major salivary gland cancer.

Objectives: To explore the prognostic effects of previous cancer history on patients with major salivary gland cancer (SGC).

Subjects And Methods: SGC patients with (sec-SGC) and without (one-SGC) a previous cancer from the SEER database were identified. Cox proportional hazards regression (CoxPH) models were used to compare the prognosis between sec-SGC and one-SGC patients.

Wavelet-Based Texture Reformation Network for Image Super-Resolution.

Most reference-based image super-resolution (RefSR) methods directly leverage the raw features extracted from a pretrained VGG encoder to transfer the matched texture information from a reference image to a low-resolution image. We argue that simply operating on these raw features neglects the influence of irrelevant and redundant information and the importance of abundant high-frequency representations, leading to undesirable texture matching and transfer results. Taking the advantages of wavelet transformation, which represents the contextual and textural information of features at different scales, we propose a Wavelet-based Texture Reformation Network (WTRN) for RefSR.

The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2.

Numerous studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect host cells through binding to angiotensin I converting enzyme 2 (ACE2) expressing in various tissues and organs. In this study, we deeply analyzed the single-cell expression profiles of in fetal and adult human hearts to explore the potential mechanism of SARS-CoV-2 harming the heart. The molecular docking software was used to simulate the binding of SARS-CoV-2 and its variant spike protein with ACE2.

Seed-sol-assisted construction of a coffin-shaped multilamellar ZSM-5 single crystal using CTAB.

A coffin-shaped multilamellar ZSM-5 single crystal (CMZS) composed of orderly stacked 2D nanosheets (70-100 nm) was synthesized the use of cetyltrimethylammonium bromide (CTAB) in the presence of silicalite-1 seed sol. This crystallization strategy opens a facile approach for industrial applications using CMZS in the catalytic conversion of bulky molecules.

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy.

Background: Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also euchromatin by alone or associates with the lamina-associated polypeptide 2 alpha (LAP2α). Numerous studies have documented that LMNA regulates gene expression by interacting with LADs in heterochromatin.

Integrated analysis of mRNA and microRNA expression profiles reveals differential transcriptome signature in ischaemic and dilated cardiomyopathy induced heart failure.

Cardiac remodelling is widely accepted as a common characteristic for many heart diseases, especially in heart failure (HF). Ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are associated with cardiac remodelling. Both mRNA and microRNA are potential diagnostic markers and therapeutic targets of cardiac remodelling in HF.