Integrated single-cell sequencing, spatial transcriptome sequencing and bulk RNA sequencing highlights the molecular characteristics of parthanatos in gastric cancer.

Background: Parthanatos is a novel programmatic form of cell death based on DNA damage and PARP-1 dependency. Nevertheless, its specific role in the context of gastric cancer (GC) remains uncertain.

Methods: In this study, we integrated multi-omics algorithms to investigate the molecular characteristics of parthanatos in GC.

Will purposely seeking detect more colorectal polyps than routine performing during colonoscopy?

Background & Goals: We observed that the number of colorectal polyps found intraoperatively was often higher than that encountered preoperatively during elective colonoscopic polypectomy. To evaluate whether more polyps can be detected when they are purposely sought than when they are routinely examined during colonoscopy.

Materials And Methods: Patients undergoing colonoscopy were randomized into groups A and B.

Genome-wide identification and analysis of the gene family in maize.

As one of the non-selective cation channel gene families, the cyclic nucleotide-gated channel (CNGC) gene family plays a vital role in plant physiological processes that are related to signal pathways, plant development, and environmental stresses. However, genome-wide identification and analysis of the gene family in maize has not yet been undertaken. In the present study, twelve genes were identified in the maize genome, which were unevenly distributed on chromosomes 1, 2, 4, 5, 6, 7, and 8.

[Gene Expression and Clinical Characteristics of Molecular Targeted Therapy in Non-small Cell Lung Cancer Patients in Shandong].

Background: Molecular targeted therapy has gradually become an important treatment for lung cancer, the aim of this research is to analyze the clinicopathologic features associated with the gene mutation status of epidermal growth factor receptor (EGFR), echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) and Kirsten rat sarcoma viral oncogene (KRAS) in non-small cell lung cancer (NSCLC) patients and determine the most likely populations to benefit from molecular target therapy treatment.

Methods: The mutation status of EGFR, EML4-ALK fusion gene, ROS1 and KARS gene were determined by Real-time PCR, the relationship between clinical pathologic features and concomitant gene were analyzed with χ2 test by SPSS software 19.0.

A comparison of endoscopic submucosal dissection (ESD) and radical surgery for early gastric cancer: a retrospective study.

Background: Endoscopic submucosal dissection (ESD) has become one of the mainstays of treatment for early gastric cancer (EGC). Radical surgery is also a classical treatment method for EGC. There have been no systematic clinical studies of the curative effects and adverse events associated with ESD vs.

Combined EUS and CT for evaluating gastrointestinal submucosal tumors before endoscopic resection.

Goals: The aim of this study was to evaluate the combination of endoscopic ultrasonography (EUS) and computed tomography (CT) in predicting the maneuvers for therapeutic endoscopy for gastrointestinal submucosal tumors (SMTs).

Methods: Patients with SMTs, who were scheduled for endoscopic resection, were randomized to preoperative performance of both EUS and CT (group A) or EUS only (group B). The following data were collected: therapeutic maneuvers, duration of procedure, dose of propofol, resected lesion size, and complications.

Endoscopic ultrasonography in tandem with endoscopic retrograde cholangiopancreatography in the management of suspected distal obstructive jaundice.

Goals: To examine the benefits and feasibility of endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) in tandem for distal obstructive jaundice.

Materials And Methods: From September 2007 to August 2012, patients with suspected distal obstructive jaundice were randomized to single-session EUS-ERCP (group A), EUS, and ERCP in different sessions (group B), and an ERCP-only procedure (group C). Data were prospectively collected on the following parameters: ERCP-avoided, duration of procedure, the dose of propofol, complications, and diagnostic yield.

Standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori eradication.

Aim: To compare the effectiveness of standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori (H. pylori) eradication in a randomized, double-blinded, comparative clinical trial in China.

Methods: A total of 215 H.