CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway.

Patients with hepatocellular carcinoma (HCC) at advanced stages face limited treatment options, highlighting the urgent need for more effective early detection methods and advanced therapeutic modalities. Emerging evidence shows that multiple CYP450 proteins are involved in the pathogenesis of HCC. CYP1A2, CYP2E1 and CYP3A5 have been shown to modulate important signaling pathways, hereby inhibiting the proliferation and invasion of HCC cells.

A Bifunctional Peptide with Penetration Ability for Treating Retinal Angiogenesis via Eye Drops.

Numerous diseases, such as diabetic retinopathy and age-related macular degeneration, can lead to retinal neovascularization, which can seriously impair the visual function and potentially result in blindness. The presence of the blood-retina barrier makes it challenging for ocularly administered drugs to penetrate physiological barriers and reach the ocular posterior segments, including the retina and choroid. Herein, we developed an innovative bifunctional peptide, Tat-C-RP7, which exhibits excellent penetration capabilities and antiangiogenic properties aimed at treating retinal neovascularization diseases.

MCP-enhanced SOD3 activity inhibits gastric cancer and potentiate chemotherapy via modulating EGFR signaling.

Aims: This study aims to investigate the role of SOD3 in gastric cancer (GC) progression and its impact on chemotherapy efficacy and toxicity. It further seeks to evaluate the therapeutic potential of MCP in enhancing SOD3 activity to improve treatment outcomes and reduce chemotherapy-induced peripheral neurotoxicity (CIPN).

Materials And Methods: We used overexpression plasmids and small interfering RNAs (siRNAs) to modulate the expression of SOD3 and Desmocollin2 (DSC2) in gastric cancer cells.

Reversible Anion-Cation Relay-Intercalation in a T-MnO Cathode to Boost the Efficiency of Aqueous Dual-Ion Batteries.

Benefiting from the merits of intrinsic safety, high power density, environmental friendliness, and high-output voltage, aqueous dual-ion batteries (ADIBs) have shown broad potential applications in future grid-scale energy storage. However, since the ADIBs require the cathodes to undergo the intercalation reactions through different local structures and mechanisms, causing large structural deformation and cathode failure, their reversible cation-anion intercalation in the cathode remains a major challenge. To address this issue, based on a reasonable selection and theoretical simulation, this work finds that Todorokite manganese dioxide (t-MnO) cathode with a metal-ion stabilized 3 × 3 large-tunnel structure should be suitable for cation-anion intercalation of ADIBs.

Polarization-Independent Perfect Absorption in Monolayer Black Phosphorus Metasurfaces at Terahertz Frequencies via Critical Coupling.

Two-dimensional (2D) materials, which possess rich underlying physical properties that can provide the potential for designing more efficient and compact optoelectronic devices, have attracted great interest among scientists. Due to the atomic-scale thickness and the anisotropy of in-plane conductivity, 2D black phosphorus (BP) exhibits a polarization-dependent absorption spectrum with low absorption, which limits its further development in polarization-independent applications such as light absorbers and sensors. In this paper, a polarization-independent perfect absorber in the terahertz band is proposed, which is composed of a patterned BP monolayer deposited on a lossless photonic crystal (PC) slab with a back reflection mirror.

Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease.

Background: Senolytic combination of dasatinib and quercetin (DQ) is the most studied senolytics drugs used to treat various age-related diseases. However, its protective activity against diabetic kidney disease (DKD) and underlying mechanisms are uncertain.

Purpose: To investigate the functions and potential mechanisms of the senolytics DQ on DKD.

Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation.

Background: Appropriate conditions for storage of Artemisia argyi leaves reduce irritation during treatment and increase the active ingredient content. Naturally aged A. argyi leaves (≥1 year) are optimal for moxibustion; however, this process is time-consuming and costly.

Umpolung reactivity of strained C-C σ-bonds without transition-metal catalysis.

Umpolung is an old and important concept in organic chemistry, which significantly expands the chemical space and provides unique structures. While, previous research focused on carbonyls or imine derivatives, the umpolung reactivity of polarized C-C σ-bonds still needs to explore. Herein, we report an umpolung reaction of bicyclo[1.

Pharmacokinetic and bioequivalence study of two capecitabine tablets in Chinese patients with solid tumor cancer.

Capecitabine (CAP) is one of the fluoropyrimidine deoxynucleoside carbamates, which can be converted to 5-fluorouracil (5-FU) by thymine deoxynucleoside phosphorylase (dThdPase) to exert antitumor effects. The purpose of this study is to compare the pharmacokinetics (PK), bioequivalence (BE), and safety of two CAP tablets in Chinese patients with solid tumor cancer. The results showed that the geometric mean ratios (GMRs) of C, AUC and AUC of CAP T/R reagent were 90.

Molecular classification reveals the sensitivity of lung adenocarcinoma to radiotherapy and immunotherapy: multi-omics clustering based on similarity network fusion.

Background: Due to individual differences in tumors and immune systems, the response rate to immunotherapy is low in lung adenocarcinoma (LUAD) patients. Combinations with other therapeutic strategies improve the efficacy of immunotherapy in LUAD patients. Although radioimmunotherapy has been demonstrated to effectively suppress tumors, the underlying mechanisms still need to be investigated.

Research on plasma modified fly ash denitration.

The effects of reactor parameters and process parameters on the denitration rate of modified fly ash in different gas atmospheres were studied by using a dielectric barrier plasma reactor and using orthogonal experiments. The characteristics of modified fly ash were analyzed using scanning electron microscope, specific surface area analyzer, X-ray diffraction, Boehm titration and Fourier transform infrared spectroscopy. The experimental data were processed by variance analysis and linear regression to induce the denitration mechanism.

Renal aging and mitochondrial quality control.

Mitochondria are dynamic organelles that participate in different cellular process that control metabolism, cell division, and survival, and the kidney is one of the most metabolically active organs that contains abundant mitochondria. Perturbations in mitochondrial homeostasis in the kidney can accelerate kidney aging, and maintaining mitochondrial homeostasis can effectively delay aging in the kidney. Kidney aging is a degenerative process linked to detrimental processes.

m6A RNA methylation modification is involved in the disease course of heart failure.

We explored -methyladenosine (m6A) RNA methylation as one of the gene regulatory mechanisms in heart failure (HF) biology. Understanding the different physiological mechanisms will facilitate the prevention and individualized treatment of HF. The Gene Expression Omnibus (GEO) database served as the source of the data.

Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1).

Glioblastoma multiforme (GBM) is one of the most lethal malignant tumors in the human brain, with only a few chemotherapeutic drugs available after surgery. Nitrovin (difurazone) is widely used as an antibacterial growth promoter in livestock. Here, we reported that nitrovin might be a potential anticancer lead.

Screening of Active Ingredients from Wendan Decoction in Alleviating Palmitic Acid-Induced Endothelial Cell Injury.

(1) Objective: Traditional Chinese medicine (TCM) plays an important role in the treatment of numerous illnesses. As a classic Chinese medicine, Wendan Decoction (WDD) encompasses a marvelous impact on the remedy of hyperlipidemia. It is known that hyperlipidemia leads to cardiovascular injury, therefore anti-vascular endothelial cell injury (AVECI) may be an underlying molecular mechanism of WDD in the cure of hyperlipidemia.

Copper-Catalyzed Hydroamination of -Difluoroalkenes Access to Diversified α-Difluoromethyl Amines.

The difluoromethyl group (CFH) is of great importance in medicinal chemistry. We report herein an efficient method for the synthesis of diversified α-difluoromethyl amines through copper-catalyzed hydroamination of -difluoroalkenes, where the C-N bond formed via a α-CFH transition-metal intermediate. This new reaction proceeds through Cu-H insertion to -difluoroalkenes and gives valuable alkyl-CFH-containing compounds, which overcome the much more challenged β-F elimination from α-fluoroalkyl organocopper species.

Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity.

Glutamine, as the most abundant amino acid in the body, participates in the biological synthesis of nucleotides and other non-essential amino acids in the process of cell metabolism. Recent studies showed that glutamine metabolic reprogramming is an important signal during cancer development and progression. This metabolic signature in cancer cells can promote the development of cancer by activating multiple signaling pathways and oncogenes.

Circulating galectin-3 promotes tumor-endothelium-adhesion by upregulating ICAM-1 in endothelium-derived extracellular vesicles.

The adhesion of tumor cells to vascular endothelial cells is an important process of tumor metastasis. Studies have shown that tumor could educate vascular endothelial cells to promote tumor metastasis through many ways. However, the effect of tumor cells on the functions of vascular endothelial cells-derived extracellular vesicles (H-EVs) and the mechanisms underlying their effects in tumor-endothelium adhesion in metastasis remain mysterious.

DSC2 Suppresses the Metastasis of Gastric Cancer through Inhibiting the BRD4/Snail Signaling Pathway and the Transcriptional Activity of -Catenin.

Downregulated DSC2 involved in the metastasis of cancers. Unfortunately, its role on the development of gastric cancer (GC) and the potential mechanisms remain unclear. Bioinformatics analysis, Western blot, qRT-PCR, and immunohistochemistry were performed to detect the DSC2 levels of human GC and normal stomach tissues.

Preventive effect of Atractylodis Rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK/NF-κB signals in vivo and in vitro.

Ethnopharmacological Relevance: Atractylodes lancea (Thunb.) DC. is traditionally used as a folk medicine for treating gastrointestinal diseases in China.

Psoralidin, a natural compound from Psoralea corylifolia, induces oxidative damage mediated apoptosis in colon cancer cells.

Psoralidin (PSO) is a natural coumarin isolated from the seeds of Psoralea corylifolia Linn. Previous studies have reported that PSO exerts numerous pharmacological bioactivities including antitumor. The present study aimed to investigate its anticancer effect using colon cancer cells.