Research on magnetic resonance imaging in diagnosis of Alzheimer's disease.

As a common disease in the elderly, the diagnosis of Alzheimer's disease (AD) is of great significance to the treatment and prognosis of the patients. Studies have found that magnetic resonance imaging plays an important role in the early diagnosis of Alzheimer's disease. This article tries to review the application of magnetic resonance imaging in the diagnosis and differential diagnosis of Alzheimer's disease.

Gentiopicroside Ameliorates Cerebrovascular Angiogenesis, Neuronal Injury and Immune Disorder in Rats with Cerebral Ischemia/Reperfusion Injury via VEGF and Phosphorylated Nrf2 Elevation.

Background: Cerebral ischemia-reperfusion (CI/R) injury is induction of blood flow restoration after an ischemic stroke. Gentiopicroside (GPC) is the principal active secoiridoid glycoside of . This research aimed to illuminate the function of GPC and its mechanism in CI/R injury.

Cucurbitacin B alleviates cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome-mediated inflammation and reducing oxidative stress.

Cucurbitacin B (CuB) has been demonstrated to possess anti-inflammatory and antioxidative properties. However, the effect of CuB on cerebral ischemia/reperfusion (I/R) injury was unclear. In this work, we found that CuB significantly elevated cell viability, decreased lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) production, and proinflammatory factor levels in oxygen-glucose deprivation/reoxygenation-exposed PC12 cells, reduced cerebral infarction volume and neuronal apoptosis, inhibited oxidative stress and inflammation, and improved neurological function in mice with middle cerebral artery occlusion-induced cerebral I/R injury.

Does Climate Warming Favour Early Season Species?

Plant species that start early in spring are generally more responsive to rising temperatures, raising concerns that climate warming may favour early season species and result in altered interspecific interactions and community structure and composition. This hypothesis is based on changes in spring phenology and therefore active growing season length, which would not be indicative of possible changes in growth as would changes in cumulative forcing temperatures (growing degree days/hours) in the Northern Hemisphere. In this study we analysed the effects of a moderate climate warming (2°C warmer than the 1981-2010 baseline) on the leaf-out of hypothetical species without chilling restriction and actual plant species with different chilling and forcing requirements in different parts of the globe.

Analysis of Age and Prevention Strategy on Outcome after Cerebral Venous Thrombosis.

Method: We identified adult CVST patients in our centers. Functional outcome and prevention strategy were extracted from medical records. Modified Rankin Scale (mRS) ≤ 1 is considered a good functional outcome.

Comment on "Impacts of species richness on productivity in a large-scale subtropical forest experiment".

Huang (Reports, 5 October 2018, p. 80) report significant increases in forest productivity from monocultures to multispecies mixtures in subtropical China. However, their estimated productivity decrease due to a 10% tree species loss seems high.

Role of Post-Transcriptional Control of Calpain by miR-124-3p in the Development of Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative disease prevalent in aged people, clinically characterized by progressive memory loss, behavioral and learning dysfunction, and cognitive deficits. The pathogenesis of AD is hallmarked by formation of amyloid-β peptide aggregates (Aβ) and intraneuronal neurofibrillary tangles (NFTs), which are induced by hyperphosphorylation of amyloid-β protein precursor and tau protein, respectively. The hyperphosphorylation is controlled by cyclin-dependent kinase-5 (CDK5), the aberrant activation of which is mediated by calpain (CAPN)-induced cleavage of p35 into p25.

Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice.

Aims: Given the risk of blood-brain barrier damage (BBB) caused by ischemic and tissue plasminogen activator thrombolysis, the preservation of vascular integrity is important. Angiopoietin-like 4 (ANGPTL4), a protein secreted in hypoxia, is involved in the regulation of vascular permeability. We hypothesized that Angptl4 might exert a protective effect in thrombolysis through stabilizing blood-brain barrier and inhibit hyper-permeability.

Rapidly raise blood sugar will aggravate brain damage after severe hypoglycemia in rats.

Hypoglycemia can cause rapid and severe brain damage. We studied the impact of hypoglycemic brain damage in the insulin-induced hypoglycemic rats. Thirty male rats were divided into normal blood sugar control group (group A), the blank group (group B), and the experimental group which was further divided into four groups according to the level of blood glucose reperfusion i.