Publications by authors named "Xiulei Qi"
Outer membrane vesicles (OMVs) secreted by bacteria are emerging diagnostic markers for bacterial infection or disease detection due to their carriage of various signaling molecules. However, actual biological samples of patients are extremely complex, and applying OMVs to clinical diagnosis remains a major challenge. One of the major challenges is that there are still great difficulties in the enrichment of OMVs including tedious steps and lower concentration.
View Article and Find Full Text PDFArticle Synopsis
- Exosomes are a promising source for liquid biopsy in clinical diagnosis, but traditional isolation methods lack efficiency for large sample sizes.* -
- A new method using a dysprosium-metal organic framework combined with nanofibers allows for efficient exosome capture from body fluids, enabling high throughput isolation.* -
- The method was tested on urinary exosomes from liver disease patients, revealing accurate differentiation between conditions like hepatocellular carcinoma and cirrhosis using mass spectrometry and machine learning.*
Article Synopsis
- Extracellular vesicles (EVs) are gaining attention as potential biomarkers for liquid biopsies due to their stability and protection in body fluids by phospholipid bilayers.
- The study utilizes phosphatidylserine imprinted polymers for efficient isolation of EVs from various human body fluids, followed by metabolomic analysis using high-resolution mass spectrometry.
- Results revealed distinct metabolites specific to each body fluid, with notable findings in hepatocellular carcinoma plasma samples, highlighting the potential of EVs in biomarker discovery and their importance in understanding molecular functions.
Liquid metal (LM) shows the superiority in smart wearable devices due to its biocompatibility and electromagnetic interference (EMI) shielding. However, LM based fibers that can achieve multifunctional integrated applications with biodegradability remain a daunting challenge. Herein, versatile LM based fibers are fabricated first by sonication in alginate solution to obtain LM micro/nano droplets and then wet-spinning into LM/alginate composite fibers.
View Article and Find Full Text PDFLiquid metals (LMs, e.g., EGaIn) promise a vast potential in accelerating the development of flexible electronics, smart robots, and wearable and biomedical devices.
View Article and Find Full Text PDF