Modulated Multicomponent Reaction Pathway by Pore-Confinement Effect in MOFs for Highly Efficient Catalysis of Low-Concentration CO.

The conversion of flue gas CO into high-value chemicals via multicomponent reactions (MCRs) offers the advantages of atom economy, bond-formation efficiency and product complexity. However, because of the competition between reaction sequences and pathways among substrates, the efficient synthesize the desired product is a great challenge. Herein, a porous noble-metal-free framework (Cu-TCA) was synthesized, which can highly effectively catalyze the multicomponent conversion of CO by modulating reaction pathways.

Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from Leaves.

has been extensively utilized in traditional medicine systems worldwide. The essential oil (EO) content and composition are influenced by various external and internal factors, such as climate and harvest season, making it vital to determine the optimal harvest period for high-quality EO production. This study is the first to evaluate the chemical profiles, as well as the antioxidant and antibacterial activities, of leaf oil across the four seasons.

Transcription factor ZmNAC19 promotes embryo development in Arabidopsis thaliana.

Overexpression of ZmNAC19, a NAC transcription factor gene from maize, improves embryo development in transgenic Arabidopsis. NAC proteins are plant-specific transcription factors that are involved in multiple aspects of plant growth, development and stress response. Although functions of many NAC transcription factors have been elucidated, little is known about their roles in seed development.

Dynamics of endothelial cells migration in nature-mimicking blood vessels.

Endothelial cells (ECs) migration is a crucial early step in vascular repair and tissue neovascularization. While extensive research has elucidated the biochemical drivers of endothelial motility, the impact of biophysical cues, including vessel geometry and topography, remains unclear. Herein, we present a novel approach to reconstruct 3D self-assembly blood vessels-on-a-chip that accurately replicates real vessel geometry and topography, surpassing conventional 2D flat tube formation models.

Orbital Occupancy Modulation to Optimize Intermediate Absorption for Efficient Electrocatalysts in Water Electrolysis and Zinc-Ethanol-Air Battery.

Spin engineering is a promising way to modulate the interaction between the metal d-orbital and the intermediates and thus enhance the catalytic kinetics. Herein, an innovative strategy is reported to modulate the spin state of Co by regulating its coordinating environment. o-c-CoSe-Ni is prepared as pre-catalyst, then in situ electrochemical impedance spectroscopy (EIS) and in situ Raman spectroscopy are employed to prove phase transition, and CoOOH/CoO is formed on the surface as active sites.

Research Progress of Group II Intron Splicing Factors in Land Plant Mitochondria.

Mitochondria are important organelles that provide energy for the life of cells. Group II introns are usually found in the mitochondrial genes of land plants. Correct splicing of group II introns is critical to mitochondrial gene expression, mitochondrial biological function, and plant growth and development.

The analysis of HPV integration sites based on nanopore sequencing and the profiling changes along the course of photodynamic therapy.

Objective: To detect the HPV genotype and integration sites in patients with high-risk HPV infection at different stages of photodynamic therapy using nanopore technology and to evaluate the treatment effect.

Methods: Four patients with HPV infection were selected and subjected to photodynamic therapy, and cervical exfoliated cell was sampled at before treatment, after three courses of treatment and six courses of treatment, their viral abundance and insertion sites were analyzed by nanopore technology, and pathological examinations were performed before and after treatment. In this study, we developed a novel assay that combined viral sequence enrichment and Nanopore sequencing for identification of HPV genotype and integration sites at once.

Study on Microstructure Evolution Mechanism of Gradient Structure Surface of AA7075 Aluminum Alloy by Ultrasonic Surface Rolling Treatment.

The materials with grain size gradient variation on the surface, which were prepared with mechanical-induced severe plastic deformation, always show high resistance to high and low cycle fatigue and frictional wear because of their good strength-ductility synergy. The ultrasonic surface rolling treatment (USRT) has the advantages of high processing efficiency, good surface quality, and large residual compressive stress introduced to the surface after treatment. The USRT was used to prepare aluminum alloy (AA7075) samples with a surface gradient structure; meanwhile, the microstructural evolution mechanism of the deformation layers on the gradient structure was studied with XRD, SEM, and TEM.

First principles study of structural and electron properties in scorodite: the bulk and surface.

Scorodite (FeAsO·2HO) is an ideal material for the fixation of arsenic that has attracted considerable research interest in recent decades. However, the position of the H atom in the scorodite crystal structure, water molecular configuration, surface morphology, and chemical state of the surface atoms have not been reported. In this work, density functional theory (DFT) is used to optimize the scorodite crystal structure, and the atomic bonding is analyzed.

Clinical Efficacy and Safety of AdV-tk Gene Therapy for Patients with Cervical Squamous Intraepithelial Lesion: A Prospective Study.

Cervical cancer is the fourth most common type of cancer for women in 2020, and many more women have cervical precancerous lesion-squamous intraepithelial lesion (SIL). Early treatment of cervical SIL to reverse or delay its progression is an important approach to reduce the incidence of cervical cancer. The efficacy and safety of adenovirus-based vectors expressing the thymidine kinase gene (AdV-tk) in the treatment of multiple types of cancers shows promise for its use in gynecology.

Spatial-Temporal EEG Fusion Based on Neural Network for Major Depressive Disorder Detection.

In view of the major depressive disorder characteristics such as high mortality as well as high recurrence, it is important to explore an objective and effective detection method for major depressive disorder. Considering the advantages complementary of different machine learning algorithms in information mining process, as well as the fusion complementary of different information, in this study, the spatial-temporal electroencephalography fusion framework using neural network is proposed for major depressive disorder detection. Since electroencephalography is a typical time series signal, we introduce recurrent neural network embedded in long short-term memory unit for extract temporal domain features to solve the problem of long-distance information dependence.

Atomic reconstruction and oxygen adsorption behavior of the pyrite (100) surface: a DFT study.

The analysis of the surface chemical behavior of pyrite is highly crucial in the fields of environmental conservation, metal extraction, and flotation separation. In this paper, the mechanism of atomic reconstruction on the pyrite surface and the adsorption behavior of O on a reconstructed surface are calculated by density functional theory (DFT). Different reconstruction surfaces were constructed by deleting S and Fe atoms on the (100) surface of pyrite.

Peroxymonosulfate activation by Fe-N-S co-doped tremella-like carbocatalyst for degradation of bisphenol A: Synergistic effect of pyridine N, Fe-N, thiophene S.

Bisphenol A (BPA) has received increasing attention due to its long-term industrial application and persistence in environmental pollution. Iron-based carbon catalyst activation of peroxymonosulfate (PMS) shows a good prospect for effective elimination of recalcitrant contaminants in water. Herein, considering the problem about the leaching of iron ions and the optimization of heteroatoms doping, the iron, nitrogen and sulfur co-doped tremella-like carbon catalyst (Fe-NS@C) was rationally designed using very little iron, S-CN and low-cost chitosan (CS) via the impregnation-calcination method.

Electronic Structure Modulation of Nickel Sites by Cationic Heterostructures to Optimize Ethanol Electrooxidation Activity in Alkaline Solution.

It is a good idea for efficient production of hydrogen to use ethanol oxidation reaction (EOR) in place of oxygen evolution reaction (OER) in water electrolysis process. Ni-based non-precious electrocatalysts are widely used in the conversion of ethanol to acetic acid. Here, different selenide heterostructures (NiCoSe, NiFeSe, and NiCuSe) are prepared in which Ni sites are regulated by transition metal.

hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.

Objective: Cervical cancer, one of the common types of malignant tumors progressed in women, is on the rise in developing countries. Numerous previous studies have demonstrated that hsa-mir-133a-2 miRNA is abnormally expressed in cervical cancer cells. However, its fundamental mechanism in cervical cancer needs to be further clarified.

PRMT6 physically associates with nuclear factor Y to regulate photoperiodic flowering in .

Unlabelled: The timing of floral transition is critical for reproductive success in flowering plants. In long-day (LD) plant , the floral regulator gene () is a major component of the mobile florigen. expression is rhythmically activated by CONSTANS (CO), and specifically accumulated at dusk of LDs.

Genome-edited ATP BINDING CASSETTE B1 transporter SD8 knockouts show optimized rice architecture without yield penalty.

This study reports the identification of the rice open reading frame Semi-Dwarf in chr8 (SD8) that encodes a putative ortholog of Arabidopsis thaliana ABCB1. Genome editing of SD8 leads to optimized rice architecture by reducing plant height and flag-leaf angle without yield penalty. Rice SD8 knockouts may also have the potential for increased yield under high density planting.

EMP80 mediates the C-to-U editing of nad7 and atp4 and interacts with ZmDYW2 in maize mitochondria.

RNA C-to-U editing is important to the expression and function of organellar genes in plants. Although several families of proteins have been identified to participate in this process, the underlying mechanism is not fully understood. Here we report the function of EMP80 in the C-to-U editing at the nad7-769 and atp4-118 sites, and the potential recruitment of ZmDYW2 as a trans deaminase in maize (Zea mays) mitochondria.

Microstructure and Phase Evolution Characteristics of the In Situ Synthesis of TiC-Reinforced AZ91D Magnesium Matrix Composites.

TiC-reinforced AZ91D magnesium alloy composites were synthesized through the in situ reaction between an AZ91D melt and Ti-C-Al preforms. The microstructural evolution characteristics and phase transformation were investigated at different melt reaction temperatures (1013, 1033, and 1053 K), with the aim of understanding the in situ formation mechanism of TiC particles from thermodynamic and kinetic perspectives. The results showed that the temperature played a critical role in determining the formation and morphology of TiC.

Functions of PPR Proteins in Plant Growth and Development.

Pentatricopeptide repeat (PPR) proteins form a large protein family in land plants, with hundreds of different members in angiosperms. In the last decade, a number of studies have shown that PPR proteins are sequence-specific RNA-binding proteins involved in multiple aspects of plant organellar RNA processing, and perform numerous functions in plants throughout their life cycle. Recently, computational and structural studies have provided new insights into the working mechanisms of PPR proteins in RNA recognition and cytidine deamination.

Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies.

Background: The emergence of COVID-19 pandemic resulted in an urgent need for the development of therapeutic interventions. Of which, neutralizing antibodies play a crucial role in the prevention and resolution of viral infection.

Methods: We generated antibody libraries from 18 different COVID-19 recovered patients and screened neutralizing antibodies to SARS-CoV-2 and its mutants.

A deep learning approach to automate whole-genome prediction of diverse epigenomic modifications in plants.

Epigenetic modifications function in gene transcription, RNA metabolism, and other biological processes. However, multiple factors currently limit the scientific utility of epigenomic datasets generated for plants. Here, using deep-learning approaches, we developed a Smart Model for Epigenetics in Plants (SMEP) to predict six types of epigenomic modifications: DNA 5-methylcytosine (5mC) and N6-methyladenosine (6mA) methylation, RNA N6-methyladenosine (m A) methylation, and three types of histone modification.

Assessment of HCMV-encoded microRNAs in plasma as potential biomarkers in pregnant women with adverse pregnancy outcomes.

Background: Human cytomegalovirus (HCMV) is the most frequent cause of congenital infections and can lead to adverse pregnancy outcomes (APOs). HCMV encodes multiple microRNAs (miRNAs) that have been reported to be partially related to host immune responses, cell cycle regulation, viral replication, and viral latency, and can be detected in human plasma. However, the relevance for HCMV-encoded miRNAs in maternal plasma as an indicator for APOs has never been evaluated.

The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature.

Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy (ADV-TK) in combination with interventional treatment could relieve the symptoms in patients with widespread splenic metastasis.