Potentially Inappropriate Medication Use Among Older Patients with Diabetes in a Chinese Community.

Background: Potentially inappropriate medications (PIMs) are frequently prescribed to older people with diabetes. This study aimed to assess the prevalence of PIM use in older people with diabetes and identify potential risk factors influencing the development of PIM use.

Methods: This was a cross-sectional study conducted in an outpatient setting in Beijing, China, using Chinese criteria.

Scutellarin Suppressed Proliferation and Induced Apoptosis in Gastric Cancer via Wnt/β-catenin Signaling Pathway.

Background: Scutellarin exerts anticancer effects on diverse malignancies. However, its function in gastric cancer has not been explored.

Objective: This study aimed to examine the anticancer effect and molecular mechanism of scutellarin in gastric cancer.

Moxibustion for diarrhea-predominant irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials.

Purpose: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder that imposes heavy burden on individuals and society. Asan external therapy of traditional Chinese medicine (TCM), moxibustion is usually used to treat IBS-D. This study aimed to explore the efficacy of moxibustion in treating patients with IBS-D.

Using MODFLOW/MT3DMS and electrical resistivity tomography to characterize organic pollutant migration in clay soil layer with a shallow water table.

The clay soil in the middle and lower reaches of the Yangtze River in China is widely distributed and the groundwater table is shallow. In order to accurately analyze the distribution and assess the potentially harmful effects of the pollutants in this region, it's necessary to study the diffusion rate and subsequent concentrations of organic pollutants. Our study area, located in Kunshan in the Jiangsu Province, represents a typical contaminated site consisting of a silty clay layer located in a shallow water table.

Mapping the contaminant plume of an abandoned hydrocarbon disposal site with geophysical and geochemical methods, Jiangsu, China.

The management and remediation of abandoned hydrocarbon-contaminated sites require detailed information on the distribution of contaminant plumes. In areas where groundwater is active, the formation of contaminant plumes is associated with hydrodynamics, the nature of the sedimentary layers, and the nature of the pollutants and the degradation process. A comprehensive survey is needed to determine this information.

Fresh underground light non-aqueous liquid (LNAPL) pollution source zone monitoring in an outdoor experiment using cross-hole electrical resistivity tomography.

Real-time monitoring of source zone of light non-aqueous liquids (LNAPLs) is important for preventing accidental pollution and taking effective underground pollution remediation measures. As a high-precision monitoring technology, cross-hole electrical resistivity tomography (CHERT) has been widely used to obtain static information regarding underground stratigraphic structures and dynamic information regarding fluid motion. The time-lapse data processing method can be used to obtain pollution zone dynamic change information.

A Seabed Real-Time Sensing System for In-Situ Long-Term Multi-Parameter Observation Applications.

Aiming at the real-time observation requirements in marine science and ocean engineering, based on underwater acoustic communication and satellite communication technology, a seabed real-time sensing system for in-situ long-term multi-parameter observation applications (SRSS/ILMO) is proposed. It consists of a seabed observation system, a sea surface relay transmission buoy, and a remote monitoring system. The system communication link is implemented by underwater acoustic communication and satellite communication.

Multicenter comparison of the efficacy on prevention of pressure ulcer in postoperative patients between two types of pressure-relieving mattresses in China.

Objective: Present study is designed to evaluate the effects of preventing pressure ulcer in surgical patients with two types of pressure-relieving mattresses.

Methods: 1074 surgical patients from 12 hospitals in China were divided into A group (static air mattress with repositioning every 2 hours, n = 562) and B group (power pressure air mattress with repositioning every 2 hours, n = 512). The patient was subjected to a pressure-relieving mattress and observed from 0-5 days after surgery.

The incidence, risk factors and characteristics of pressure ulcers in hospitalized patients in China.

Pressure ulcers are very common in hospital patients. Though many studies have been reported in many countries, the large-scale benchmarking prevalence of pressure ulcers in China is not available. The aim of this study is to quantify the prevalence of pressure ulcers and the incidence of hospital-acquired pressure ulcers and analyze risk factors in hospitalized patients in China.

Mixed polyethylene glycol-modified breviscapine-loaded solid lipid nanoparticles for improved brain bioavailability: preparation, characterization, and in vivo cerebral microdialysis evaluation in adult Sprague Dawley rats.

Breviscapine is used in the treatment of ischemic cerebrovascular diseases, but it has a low bioavailability in the brain due to its poor physicochemical properties and the activity of P-glycoprotein efflux pumps located at the blood-brain barrier. In the present study, breviscapine-loaded solid lipid nanoparticles (SLN) coated with polyethylene glycol (PEG) derivatives were formulated and evaluated for their ability to enhance brain bioavailability. The SLNs were either coated with polyethylene glycol (40) (PEG-40) stearate alone (Bre-GBSLN-PS) or a mixture of PEG-40 stearate and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-PEG2000 (DSPE-PEG2000) (Bre-GBSLN-PS-DSPE) and were characterized both in vitro and in vivo.

Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies.

In this study, tetrandrine-loaded cationic solid lipid nanoparticles (TET-CNP) and solid lipid nanoparticles (TET-NP) were prepared by the emulsion evaporation-solidification at low temperature method. The particle size, zeta potential, and entrapment efficiency of TET-CNP and TET-NP were characterized. The results showed that the TET-CNP and TET-NP had average diameters of (15.