Publications by authors named "Xiujun Gao"

Orthotopic tumor model has become an essential tool for studying drug biodistribution and tumor progression over time owing to the rapid development of in vivo imaging and immunological science. Dynamic diffuse fluorescence tomography (DFT) is a promising imaging modality that can map the three-dimensional distribution of a fluorophore within the object and capture the metabolic parameters of fluorophores in vivo. It has been widely applied in tumor detection, drug development, and efficacy evaluation.

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Purpose: Chemotherapy remains the primary therapeutic approach for advanced Hepatocellular Carcinoma (HCC). The therapeutic effect of chemotherapy is limited and the toxic side effects are serious. The aim of this study is to develop a nanobubble that is ultrasonically responsive to reduce the toxic side effects of direct chemotherapy.

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, a traditional Chinese medicine with a history spanning thousands of years, faces overexploitation and challenges related to extended growth periods. Tissue-cultured adventitious roots and stem cells are alternatives to wild and field-cultivated ginseng. In this study, we assessed the in vitro xanthine oxidase and α-glucosidase inhibitory activities of saponin extracts among cultured cambial meristematic cells (CMC), adventitious ginseng roots (AGR), and field-cultivated ginseng roots (CGR).

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IR780 iodide is a commercially available targeted near-infrared contrast agent for in vivo imaging and cancer photodynamic or photothermal therapy, whereas the accumulation, dynamics, and retention of IR780 in biological tissue, especially in tumor is still under-explored. Diffuse fluorescence tomography (DFT) can be used for localization and quantification of the three-dimensional distribution of NIR fluorophores. Herein, a homemade DFT imaging system combined with tumor-targeted IR780 was utilized for cancer imaging and pharmacokinetic evaluation.

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Background: Common ginsenosides can be transformed into rare ginsenosides through microbial fermentation, and some rare ginsenosides can prevent Alzheimer's disease (AD). This study aimed to transform common ginsenosides into rare ginsenosides through solid-state fermentation of American ginseng stems and leaves (AGSL) by an endophytic fungus and to explore whether fermented saponin extracts prevent AD.

Methods: The powders of AGSL were fermented in a solid state by endophytic fungus.

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Background: Prolonged treatment of HER2+ breast cancer with lapatinib (LAP) causes cellular senescence and acquired drug resistance, which often associating with poor prognosis for patients. We aim to explore the correlation between cellular senescence and LAP resistance in HER2+ breast cancer, screen for molecular marker of reversible senescence, and construct targeted nanobubbles for ultrasound molecular imaging to dynamically evaluate LAP resistance.

Methods And Results: In this study, we established a new cellular model of reversible cellular senescence using LAP and HER2+ breast cancer cells and found that reversible senescence contributed to LAP resistance in HER2+ breast cancer.

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Background: Some fungal endophytes isolated from may present a new method of obtaining saponins. This experiment aimed to optimize the total saponin yield produced through in vitro fermentation by an endophytic fungus and analyze its saponin species in the fermented extract.

Methods: Fermentation protocols were optimized with a uniform design and verified through regression analysis to maximize the total saponin yield.

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Cancer drugs usually have side effects in chemotherapy. Apoptin, a protein recognized by its good therapeutical effect on tumors and innocuous to body, is employed to treat hepatocellular carcinoma (HCC). As our previous data shown, the efficiency of apoptin protein might be limited by the protein of apaf-1.

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Three-dimensional (3D) laser nanoprinting with high resolution and low cost is highly desirable for fabricating arbitrary 3D structures with fine feature size. In this work, we use a 405-nm integrated fiber-coupled continuous wave (cw) laser diode to establish an easy-to-build 3D nanoprinting system based on two-step absorption. Two-dimensional (2D) gratings with a sub-150-nm period and 3D woodpile nanostructures with a lateral period of 350 nm have been printed at a low speed.

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Multivalent salt plays important roles in polyelectrolyte (PE) systems. Some special effects, such as ion mediated electrostatic correlation and reentrant condensation can be induced in the presence of multivalent salt. In this work, the self-assembly behaviors of diblock PEs in trivalent salt solutions are mainly investigated by molecular dynamics (MD) simulations, and partial results are qualitatively verified by experiments.

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Background/objectives: Neurosyphilis is a disease caused by when it invades the central nervous system. Asymptomatic neurosyphilis (ANS) is one of the most common types of neurosyphilis, however it is often misdiagnosed. This study aimed to explore the impact of ANS on patient's quality of life and social stigma.

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Article Synopsis
  • Quasi-2D perovskites show potential for use in light-emitting diodes but struggle with efficiency and stability due to defects and poor energy transfer.
  • The introduction of phenethylammonium bromine-modified CsPbBr nanocrystals (PEA-CsPbBr NCs) addresses these issues by reducing leakage currents and passing Cs and Br to fix defects, while also creating a better energy-transfer pathway.
  • A new hole-transport layer was created, leading to a remarkable external quantum efficiency of 25.32%, maximum brightness of 128,842 cd/m², and a lifespan of 174 minutes under testing, all while emitting pure green light at 530 nm.
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Heavy metal pollution in the Antarctic has gone beyond our imagination. Copper toxicity is a selective pressure on Planococcus sp. O5.

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Article Synopsis
  • Recent coronavirus outbreaks have posed significant public health challenges, highlighting the need for effective treatments.
  • This study targets the 3C-like proteinase (3CLpro) of SARS-CoV-2 as a key drug target, optimizing and evaluating 251 compounds to find the most promising candidates.
  • Advanced calculations and simulations indicated that four selected compounds show strong potential for further development as anti-coronavirus treatments based on their binding interactions with 3CLpro.
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Integration of multiple advantages in one system has been leveraged to overcome multiple biological barriers in anti-tumor therapeutic strategies. In this study, multi-functional nanoparticles (MFNPs) are constructed by layer-by-layer method. MFNPs are modified with pH-responsive elastic PEG-GPC3MAb (glypican-3 monoclonal antibody), which draws back into PEG layer in blood and normal tissues; and stretches out of MFNPs surface in the acidic tumor microenvironment.

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A Gram-negative, non-motile, non-spore-forming, aerobic and short rod-shaped bacterial strain R32, was isolated from seawater of the South Atlantic Ocean. Strain R32 grew at 10-40 °C (optimum 28 °C), at pH 6.0-8.

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Background: Addiction to online games is not uncommon. The patients usually refuse to take medications and present with affective symptoms such as anxiety, depression and negative coping styles. Psychological intervention based on positive psychology is a promising treatment for such patients.

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A comparative investigation on the photophysical properties of a quinoxaline derivative 4,4'-((1,1')-quinoxaline-2,3-diylbis(ethene-2,1-diyl))bis(,-dimethylaniline) (QDMA2) was performed by employing many spectroscopies. Based on the pump-dump/push-probe measurement, it is found that a solvent-stabilized charge-transfer state can participate in the relaxation of excited QDMA2 with increasing solvent polarity. Meanwhile, the aggregated QDMA2 molecules were engineered into the organic light-emitting diode test, which showed a correlated color temperature value of 1875 K.

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Despite recent studies, relatively few are known about the diversity of fungal communities in the deep Atlantic Ocean. In this study, we investigated the diversity of fungal communities in 15 different deep-sea sediments from the South Atlantic Ocean with a culture-dependent approach followed by phylogenetic analysis of ITS sequences. A total of 29 fungal strains were isolated from the 15 deep-sea sediments.

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The photophysical properties of a donor-acceptor compound based on triphenylamine-modified vinylbenzothiazole derivative (BTTM) are investigated by multispectral techniques. Based on the pump-probe and pump-dump/push-probe technique, it is found that the hybridized localized excited (LE) and charge transfer (CT) state (HLCT) participates in the relaxation process of excited BTTM. The excited state is the LE-dominated HLCT state in cyclohexane; then it evolves to the CT-dominated HLCT state in a high polarity solvent.

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A bioinspired structure of an artificial mushroom, made of the common polyvinyl alcohol sponge coated with charcoal, is fabricated, with high efficiency in generating cold water steam of ≈73% under 1 sun illumination, due to very high light absorption, efficient water supply, and low heat loss. In addition, the structure is very inexpensive, and thus ideal for applications in portable cold (boil-free) steam generators for water purification and desalination.

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The deep-sea bacterium strain FA13 was isolated from the sediment of the South Atlantic Ocean and identified as Bacillus circulans based on 16S ribosomal DNA sequence. Through liquid fermentation with five media, the cell-free supernatant fermented with ISP2 showed the highest inhibition activities against mycelial growth of Aspergillus parasiticus mutant strain NFRI-95 and accumulation of norsolorinic acid, a precursor for aflatoxin production. Based on ISP2, uniform design was used to optimize medium formula and fermentation conditions.

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Chemotherapy has been the standard for cancer therapy, but the nonspecific cytotoxicity of chemotherapeutic agents and drug resistance of tumor cells has limited its efficacy. However, multidrug combination therapy and targeting therapy have resulted in enhanced anticancer effects and have become increasingly important strategies in clinical applications. In this study, a biotin-/lactobionic acid-modified poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol) (BLPP) copolymer was synthesized, and curcumin- and 5-fluorouracil-loaded nanoparticles (BLPPNPs/C + F) were prepared to enhance the treatment of hepatocellular carcinoma.

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Boron carbon oxynitride quantum dots (BCNO QDs) with blue emission were prepared via the template of SBA-15 (a typical mesoporous silica). A modulated photoluminescence sensor was developed based on the different quenching effects of Cu or Hg ions on the luminescence intensity of BCNO QDs. The Cu or Hg ions have an interaction with BCNO QDs due to the electrons transfer between the BCNO and Cu or Hg ions, and the detection limit of Cu or Hg ion concentration can be as less as 10 nM.

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