Efficacy of Linaclotide in Functional Dyspepsia and Constipation-Predominant Irritable Bowel Syndrome Overlap: A Randomized Trial.

Background And Aim: Linaclotide is effective in relieving constipation-predominant irritable bowel syndrome symptoms. However, few studies focus on the efficacy of linaclotide for overlapping symptoms of functional dyspepsia among irritable bowel syndrome patients. This study aimed to assess the efficacy of linaclotide compared with lactulose in patients with functional dyspepsia and constipation-predominant irritable bowel syndrome overlap.

Nanoporous Graphene with Encapsulated Multicomponent Carbide as High-Performance Binder-Free Lithium-Ion Battery Anodes.

Metal carbides are considered attractive lithium-ion battery (LIB) anode materials. Their potential practical application, however, still needs nanostructure optimization to further enhance the Li-storage capacity, especially under large current densities. Herein, a nanoporous structured multi-metal carbide is designed, which is encapsulated in a 3D free-standing nanotubular graphene film (MnNiCoFe-MoC@NG).

The sentinels of coronary artery disease: heterogeneous monocytes.

Monocytes are heterogeneous immune cells that play a crucial role in the inflammatory response during atherosclerosis, influencing the progression and outcome of the disease. In the pathogenesis of atherosclerotic diseases, such as coronary artery disease (CAD), monocytes not only serve as the initial sensors of endogenous and exogenous pathogenic factors, but also function as intermediators that bridge the circulatory system and localized lesions. In the bloodstream, heterogeneous monocytes, acting as sentinels, are rapidly recruited to atherosclerotic lesions, where they exhibit a heightened capacity to respond to various pathological stimuli upon detecting signals from damaged vascular endothelial cells.

Regulation of the immune microenvironment by SUMO in diabetes mellitus.

Post-translational modifications such as SUMOylation are crucial for the functionality and signal transduction of a diverse array of proteins. Analogous to ubiquitination, SUMOylation has garnered significant attention from researchers and has been implicated in the pathogenesis of various human diseases in recent years, such as cancer, neurological lesions, cardiovascular diseases, diabetes mellitus, and so on. The pathogenesis of diabetes, particularly type 1 and type 2 diabetes, has been closely associated with immune dysfunction, which constitutes the primary focus of this review.

Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study.

Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident diabetes risk in both men and women remains unidentified in prospective cohort studies. In this study, we examined a panel of nine serum SCFAs and BCFAs in 3414 subjects with incident diabetes, and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort study.

L-serine metabolic regulation and host respiratory homeostasis.

LSerine, a non-essential amino acid (NEAA), can be obtained through diet or synthesis. Functionally, L-serine not only serves as the precursor of other amino acids, lipids, and nucleotides, but also participates in the folate/methionine cycle. An increasing number of studies have demonstrated that L-serine is widely used in the adjuvant therapy of many diseases (e.

A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8 T cell test.

Since the outbreak of the coronavirus disease 2019 (COVID-19) epidemic in 2019, the public health system has faced enormous challenges. Tracking the individuals who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated mortality. With the increasing of asymptomatic infections, it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome sequencing.

The impact of a PERMA model-based positive psychology intervention on fear of stroke recurrence: a randomized controlled trial.

Introduction: This study aimed to examine the effects of a positive psychological intervention, grounded in the PERMA model, on fear levels, psychological capital, overall well-being, and quality of life among stroke patients.

Methods: A single-blind, two-arm randomized controlled trial with a repeated measures design was conducted at the Affiliated Hospital of Jiangnan University from January to December 2023. A total of 125 patients experiencing fear of stroke recurrence were randomly assigned to either the intervention group ( = 63), which received a positive psychological intervention based on the PERMA model, or the control group ( = 62), which received standard care.

Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030.

Background: Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of Colorectal cancer cases and deaths can be attributed to modifiable risk factors, with smoking, alcohol use, and high body mass index (BMI) being the three most prominent. However, the impact of these risk factors on Colorectal cancer across regions, genders, and age groups remains insufficiently characterized.

Prevalence of breast cancer in ovarian cancer patients and its impact on patient survival: An analysis of the surveillance, epidemiology, and end results data.

Background: Patients with high-grade serous ovarian carcinoma (HGSOC) often have a personal and/or family history of breast cancers. However, the clinical association and underlying molecular interaction between breast cancer and HGSOC is not well understood. In this study, the clinical characteristics and outcomes of HGSOC patients with or without breast cancer were compared.

Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization.

The treatment of erectile dysfunction (ED) remains a significant challenge. Mendelian randomization (MR) is being increasingly utilized to identify novel therapeutic targets. In this study, we carried out a genome-wide MR analysis on druggable targets with the aim of pinpointing latent therapeutic alternatives for ED.

Metabolomic Analysis of Flavour Development in Mung Bean Foods: Impact of Thermal Processing and Storage on Precursor and Volatile Compounds.

Consumers prefer mung beans for their low allergenicity and nutritional benefits. However, flavour development in mung bean foods has been problematic, with beany flavour being a limiting factor. Hot processing is crucial in forming mung bean flavours, and storage-induced changes in flavour precursors directly impact the taste post-processing.

Research on Control Strategy of Stainless Steel Diamond Plate Pattern Height Rolling Based on Local Constraints.

The rolling system for stainless steel, particularly in the production of diamond plates, represents a complex industrial control scenario. The process requires precise load distribution to effectively manage pattern height, due to the high strength, hardness, and required dimensional accuracy of the material. This paper addresses the limitations of offline methods, which include heavy reliance on initial conditions, intricate parameter settings, susceptibility to local optima, and suboptimal performance under stringent constraints.

Random Forest Algorithm for the Mechanical Strength Prediction of Green Cement-Based Materials Incorporating Waste Materials Under Fire Condition.

High temperature treatment is a typical detrimental situation that may significantly influence the compressive strength of cement-based materials. It was reported that the incorporation of common waste materials as supplementary cementitious materials (SCMs) can improve high temperature resistance. In this work, fly ash (FA), granulated blast-furnace slag (GGBFS), and silica fume (SF) were used as SCMs to replace cement to produce green cement-based materials.

Family Physicians' Use of, Barriers to, and Attitudes Toward Remote Diagnosis and Treatment in China: A National Web-Based Survey.

China has introduced a series of policies to encourage family physicians (FPs) to provide remote diagnosis and treatment (RDT) services, with the ultimate goal of providing more continuous, convenient, and efficient medical services for all residents, especially elderly patients and patients with chronic diseases. However, few studies have focused on this important issue. The aim of this study was to provide a comprehensive description of FPs' use of, barriers to, and attitudes toward RDT in China.

Identification of Quantitative Trait Loci for Node Number, Pod Number, and Seed Number in Soybean.

Optimizing soybean yield remains a crucial challenge in meeting global food security demands. In this study, we report a comprehensive genetic analysis of yield-related traits in soybeans using a recombinant inbred line (RIL) population derived from crosses between 'Qihuang 34' (GH34) and 'Dongsheng 16' (DS16). Phenotypic analysis across two years (2023-2024) revealed significant variations between parental lines.

Expressing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Single-Chain Antibody Can Inhibit PRRSV Replication and Change the Intestinal Flora Structure of Piglets.

Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease that can cause reproductive disorders in sows and affect the breathing of piglets, seriously endangering pig breeding worldwide. In this study, NC8 was used as the expression delivery vector of foreign proteins, and a single-chain antibody was designed based on an mAb-PN9cx3 sequence. Three recombinant strains of , namely, NC8/pSIP409-pgsA'-PN9cx3-scFV(E), NC8/pSIP409-pgsA'-PN9cx3-HC(E), and NC8/pSIP409-pgsA'-PN9cx3-LC(E), were successfully constructed.

Screening for Resistant Germplasms and Quantitative Trait Locus Mapping of Resistance to Tomato Chlorosis Virus.

Tomato chlorosis virus (ToCV) is an emerging plant virus that poses a substantial threat to the cultivation of economically vital vegetable crops, particularly tomato (). Despite its substantial impact on crop yield, resistant or tolerant tomato germplasms have not been well documented, and the genetic basis of resistance to ToCV remains poorly understood. In this study, two wild accessions that were immune to ToCV and five accessions that were highly resistant to ToCV were identified from 58 tomato accessions.

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomics Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment.

Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to adapt to and exploit their microenvironment for sustained growth. The liver is a common site of metastasis, but the interactions between tumor cells and hepatocytes remain poorly understood. In the context of liver metastasis, these interactions play a crucial role in promoting tumor survival and progression.

Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment.

Per- and polyfluoroalkyl substances (PFASs) have been widely used in the production of consumer products globally due to the excellent water and oil resistance and anti-fouling properties. The multiple toxic effects of some PFASs also pose a threat to human health and ecosystem, and the frequent use of certain consumer products increased the risk of human exposure to PFASs. More data on the occurrence, concentration, and migration of PFASs in consumer products is urgently needed to address the possible risks posed by exposure to consumer products.

Synthesis, Structure and Iodine Adsorption Properties of a Ni Cluster-Based Supramolecular Framework.

The capture of radioactive iodine (129I or 131I) is of significant importance for the production of nuclear power and the treatment of nuclear waste. In recent years, crystallized porous materials have been extensively investigated to achieve highly effective adsorption of radioactive iodine. Herein, by using the hydrothermal method, a Ni cluster-based framework () was successfully constructed through a self-assembly process.

Effects of Modification on Properties of Wood Flour/PBAT Biocomposites.

Wood flour (WF)-reinforced poly (butylene adipate-co-terephthalate) (PBAT) composites were successfully fabricated by injection-molding process after being mixed using an extruder. The effects of fiber modifications, including mercerization, acetylation, as well as coupling agent treatment on the properties of WF/PBAT composites, were studied. The results indicated that all the modifications increased the mechanical properties (e.

Analysis of the Transcriptional Control of in Chicken: IRF1 and GATA1 as Negative Regulators.

B-cell lymphoma/leukemia 11B (Bcl11b) plays roles in cell proliferation and apoptosis and holds a pivotal position within the immune system. Our previous studies have demonstrated that Bcl11b can promote cell apoptosis to curb ALV-J infection. To gain insights into the molecular mechanisms underlying expression regulation in chickens, we constructed various truncated dual luciferase reporter vectors and analyzed the promoter region of .

Residue Depletion and Withdrawal Interval Estimations of Sulfamonomethoxine or Doxycycline Residues in Chinese Taihe Black-Bone Silky Fowls.

Black-bone fowls are rich in melanin and regarded as being rich in nutritional value. However, the metabolism of antibiotics in black-bone fowls remains poorly understood. This study aimed to determine the tissue residue depletion kinetics of Sulfamonomethoxine (SMM) or Doxycycline in Taihe black-bone silky fowls.

Chromosomal Location and Identification of as a New Gene Responsible for Familial Bicuspid Aortic Valve.

Congenital bicuspid aortic valve (BAV) signifies the most frequent category of congenital cardiovascular anomaly globally, occurring in approximately 0.5-2% of the general population worldwide. BAV is a major cause of thoracic aortopathy, encompassing aortic stenosis, aortic root dilation with regurgitation, aortic dissection, and aortic aneurysms, consequently leading to substantial late-onset morbidity and mortality.