Effects of climate and environment on migratory old people with allergic diseases in China: Protocol for a Sanya cohort study.

Background: Several studies have reported that the mountain climate can alleviate asthma, however, the effect of tropical climate on migratory elderly, especially in people with respiratory or allergic diseases is unknown.

Objectives: This cohort study aims to explore impact of climate and environmental changes on allergic diseases in migratory old people.

Methods: In this prospective cohort study, we recruited 750 older migratory people, the majority of whom were homeowners to minimize the risk of loss to follow up.

Deep removal of trace CH and CO from CH by using customized potassium-exchange mordenite.

Adsorptive separation using porous materials is a promising approach for separating alkynes/olefins due to its energy efficiency, while the deep removal of trace amounts of CH and CO from CH is still very challenging for a commercial adsorbent. Herein, we report a low-cost inorganic metal cation-mediated mordenite (MOR) zeolite with the specific location and distribution of K cations acting as a goalkeeper for accurately controlling diffusion channels, as evidence of the experimental and simulation results. Deep purification of CH from ternary CO/CH/CH mixtures was first realized on K-MOR with exceptional results, achieving a remarkable polymer-grade CH productivity of 1742 L kg for the CO/CH/CH mixture.

Contrasting prokaryotic and eukaryotic community assembly and species coexistence in acid mine drainage-polluted waters.

Acid mine drainage (AMD) is characterized by high acidity and high-concentration metals and sulfate, representing an extreme environment to life as well as environmental challenge worldwide. Microorganisms thriving in AMD habitats have evolved with distinct mechanisms in response to multiple stresses. Compared with microbial prokaryotes, our understanding regarding eukaryotic occurrence and role in AMD habitats remain limited.

Fabrication of Nanosuspensions to Improve the Oral Bioavailability of Total Flavones from Hippophae rhamnoides L. and their Comparison with an Inclusion Complex.

The aim of this work was to increase the solubility and oral bioavailability of isorhamnetin, kaempferol, and quercetin in the total flavones of Hippophae rhamnoides L. (TFH) by preparing their nanosuspensions (NSs) and an inclusion complex. Based on the particle size and zeta potential, P407, Soluplus, SDS, PEG-6000, and HP-β-CD were selected as stabilizers.

Mechanism and catalytic performance for direct dimethyl ether synthesis by CO hydrogenation over CuZnZr/ferrierite hybrid catalyst.

Direct synthesis of dimethyl ether (DME) by CO hydrogenation has been investigated over three hybrid catalysts prepared by different methods: co-precipitation, sol-gel, and solid grinding to produce mixed Cu, ZnO, ZrO catalysts that were physically mixed with a commercial ferrierite (FER) zeolite. The catalysts were characterized by N physisorption, X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), temperature programmed desorption of CO (CO-TPD), temperature programmed desorption of NH (NH-TPD), and temperature programmed H reduction (H-TPR). The results demonstrate that smaller CuO and Cu crystallite sizes resulting in better dispersion of the active phases, higher surface area, and lower reduction temperature are all favorable for catalytic activity.

Incorporating User Generated Content for Drug Drug Interaction Extraction Based on Full Attention Mechanism.

It is crucial for doctors to fully understand the interaction between drugs in prescriptions, especially when a patient takes multiple medications at the same time during treatment. The purpose of drug drug interaction (DDI) extraction is to automatically obtain the interaction between drugs from biomedical literature. Current state-of-the-art approaches for DDI extraction task are based on artificial intelligence and natural language processing.

Development of daidzein nanosuspensions: Preparation, characterization, in vitro evaluation, and pharmacokinetic analysis.

The purpose of this investigation was to improve the solubility and oral bioavailability of daidzein via preparing nanosuspensions (NS) with steric stabilizers, electrostatic stabilizers, or a combination of both. Based on particle size and zeta potential, daidzein NS stabilized by HP-β-CD, soy lecithin, HP-β-CD + soy lecithin, TPGS, TPGS + SBE-β-CD, SDS, or HPMC E5 + SDS were generated and characterized by scanning electron microscopy, powder X-ray diffraction, and Fourier transform-infrared spectroscopy. In addition, the stability, cytotoxicity, solubility, dissolution, and pharmacokinetics of NS were evaluated.

Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2.

Background: Isorhamnetin (IS) is a flavonoid component with many biological activities such as antioxidant, anti-inflammatory, and anticancer, which is also the main active component in total flavones of Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) (TFH); however, the interaction between IS and other components in TFH is unclear.

A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang.

Ban-Xia-Xie-Xin-Tang (BXXXT) is a classical formula from Shang-Han-Lun which is one of the earliest books of TCM clinical practice. In this work, we investigated the therapeutic mechanisms of BXXXT for the treatment of multiple diseases using a network pharmacology approach. Here three BXXXT representative diseases (colitis, diabetes mellitus, and gastric cancer) were discussed, and we focus on in silico methods that integrate drug-likeness screening, target prioritizing, and multilayer network extending.

Solvothermal-assisted evaporation-induced self-assembly of ordered mesoporous alumina with improved performance.

A solvothermal-assisted evaporation-induced self-assembly (SA-EISA) approach has been developed for the synthesis of ordered mesoporous alumina (OMA) materials with high thermal stability and improved performance in catalysis. In conventional EISA process, the evaporation step is accompanied by the hydrolysis of organic aluminum precursors, thus the evaporation conditions have significant influences on the reaction and the final structure of OMA. In our approach, the solvothermal treatment step promotes the complete hydrolysis of aluminum precursors and produces partially condensed cluster-like aluminum hydroxyl species, which allows the formation of OMA in a broad range of evaporation conditions.

A novel adaptive ensemble classification framework for ADME prediction.

It has now become clear that prediction of ADME (absorption, distribution, metabolism, and elimination) characteristics is an important component of the drug discovery process. Therefore, there has been considerable interest in the development of modeling of ADME prediction in recent years. Despite the advances in this field, there remains challenges when facing the unbalanced and high dimensionality problems simultaneously.

The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model.

The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and intestinal flora could participate in their absorption processes.

Efficient bioconversion of L-glutamate to γ-aminobutyric acid by Lactobacillus brevis resting cells.

This work investigated the efficient bioconversion process of L-glutamate to GABA by Lactobacillus brevis TCCC 13007 resting cells. The optimal bioconversion system was composed of 50 g/L 48 h cultivated wet resting cells, 0.1 mM pyridoxal phosphate in glutamate-containing 0.

Development of in Silico Models for Predicting P-Glycoprotein Inhibitors Based on a Two-Step Approach for Feature Selection and Its Application to Chinese Herbal Medicine Screening.

P-glycoprotein (P-gp) is regarded as an important factor in determining the ADMET (absorption, distribution, metabolism, elimination, and toxicity) characteristics of drugs and drug candidates. Successful prediction of P-gp inhibitors can thus lead to an improved understanding of the underlying mechanisms of both changes in the pharmacokinetics of drugs and drug-drug interactions. Therefore, there has been considerable interest in the development of in silico modeling of P-gp inhibitors in recent years.

[Effect of Solanum nigrum on human colon carcinoma RKO cells ].

Objective: To evaluate the effect of Solanum nigrum on adhesion, migration and invasion in human colon carcinoma RKO cells.

Methods: RKO cells were treated with different dose of Solanum nigrum. Cell proliferation was detected by CCK-8 assay.

Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.

Background: Colorectal cancer remains one of the leading causes of cancer death worldwide. Traditional Chinese Medicine (TCM) has played a positive role in colorectal cancer treatment. There is a great need to establish effective herbal formula for colorectal cancer treatment.

[Application of genetic algorithm in blending technology for extractions of Cortex Fraxini].

Objective: To explore the feasibility of genetic algorithm (GA) on multiple objective blending technology for extractions of Cortex Fraxini.

Method: According to that the optimization objective was the combination of fingerprint similarity and the root-mean-square error of multiple key constituents, a new multiple objective optimization model of 10 batches extractions of Cortex Fraxini was built. The blending coefficient was obtained by genetic algorithm.

[Back-propagation neural network and genetic algorithm for multi-objective optimization of extraction technology of Cortex Fraxini].

Objective: To introduce Back-propagation (BP) neural network and genetic algorithm for multi-objective optimization of extraction technology of Cortex Fraxini.

Method: BP neural network was established and optimized with uniform design. Genetic algotithm was used for multi-objective optimization of extraction technology of cortex fraxini.

[Experimental study on electroacupuncture for strengthening gastrointestinal motility in the rat with acute pancreatitis].

Objective: To explore the mechanism of EA in treatment of acute pancreatitis.

Methods: Twenty-four healthy male Wistar rats were randomly divided into 3 groups, a control group, a model group and an EA group. In the model group, rat acute pancreatitis model was prearpared by intraperitoneal injection of Caerulein, and in the EA group, EA was given at "Zusanli" (ST 36) and "Tianshu" (ST 25) of the model rat.

[Development of the new measuring & training device for eustachian tube opening function].

This paper presents to you the principles, composition, features and applications of ET-100 measuring-training device for eustachian tube opening function.

[The psychological effect of minesweeping infrasonic field].

Objective: To investigate the effect of infrasonic field of minesweeper on psychology of minesweeper crews.

Methods: An experimental ship was selected to conduct infrasonic minesweeping, a control ship of the same type was selected to operate likewise with the infrasound generator turned off, and another group of coast-servicemen was chosen as blank control. Attention-span test, digit memory test, two-digital numbers list and profile of mood states (POMS) were used to test the ship crews and coast-servicemen.