The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging protocol, resulting in one of the largest datasets collected to-date of high spatial resolution multiple delay ASL covering 3,000 subjects. The HCP-ASL minimal processing pipeline was developed specifically for this dataset to pre-process the image data and produce perfusion estimates in both volumetric and surface template space, though quality control is not performed.
View Article and Find Full Text PDFPhotocatalytic water splitting for hydrogen production has been considered as an effective approach to address the current energy crisis and environmental challenges. Among all materials for such applications, covalent triazine frameworks (CTFs) are regarded as ideal candidates owing to their conjugated structures with rich aromatic nitrogen atoms, which can provide abundant active sites, suitable bandgaps, good structural tunability, and high chemical stability. Although current research studies have shown that the modification of functional groups in CTFs can adjust the band structure and carrier flow characteristics of photocatalysts, leading to improved performance, the impact of the intrinsic structural characteristics of CTFs (, stacking modes, hydrogen bonding) on their photocatalytic performance remains unclear.
View Article and Find Full Text PDFAs the principal lipid transporter in the human brain, apolipoprotein E (ApoE) is tasked with the transport and protection of highly vulnerable lipids required to support and remodel neuronal membranes, in a process that is dependent on ApoE receptors. Human allele variants that encode proteins differing only in the number of cysteine (Cys)-to-arginine (Arg) exchanges (ApoE2 [2 Cys], ApoE3 [1 Cys], ApoE4 [0 Cys]) comprise the strongest genetic risk factor for sporadic Alzheimer's disease (AD); however, the molecular feature(s) and resultant mechanisms that underlie these isoform-dependent effects are unknown. One signature feature of Cys is the capacity to form disulfide (Cys-Cys) bridges, which are required to form disulfide bridge-linked dimers and multimers.
View Article and Find Full Text PDFDiamond-wire sawing silicon waste (DSSW) derived from the silicon wafer sawing process may lead to resource waste and environmental issues if not properly utilized. This paper propounds a simple technique aimed at enhancing the efficiency of hydrogen production from DSSW. The hydrolysis reaction is found to become faster when DSSW is ground.
View Article and Find Full Text PDFMembers of the B-Box (BBX) family of proteins play crucial roles in the growth and development of rice. Here, we identified a rice BBX protein, Oryza sativa BBX2 (OsBBX2), which exhibits the highest expression in the root. The transcription of follows a diurnal rhythm under photoperiodic conditions, peaking at dawn.
View Article and Find Full Text PDFLong interspersed nuclear element-1 (LINE-1 or L1) is a retrotransposon group that constitutes 17% of the human genome and shows variable expression across cell types. However, the control of L1 expression and its function in gene regulation are incompletely understood. Here we show that L1 transcription activates long-range gene expression.
View Article and Find Full Text PDFPlant-based foods are gaining popularity as alternatives to meat and dairy products due to sustainability and health concerns. As a consequence, there is a renewed interest in the phase behaviour of plant proteins and of mixtures of plant proteins and polysaccharides, in particular in the cases where coacervation is found to occur, , liquid-liquid phase separation (LLPS) into two phases, one of which is rich in biopolymers and one of which is poor in biopolymer. Here we review recent research into both simple and complex coacervation in systems involving plant proteins, and their applications in food- as well as other technologies, such as microencapsulation, microgel production, adhesives, biopolymer films, and more.
View Article and Find Full Text PDFBMC Complement Med Ther
January 2024
Medicine (Baltimore)
December 2023