Publications by authors named "Xiufang Wan"

Background: Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated in the tumorigenesis and progression of various cancers, but its role in endometrial cancer (EC) is still unclear. Our current research explored the prognostic value, biological function and targeting strategy of KIF11 in EC through approaches including bioinformatics, machine learning and experimental studies.

Methods: The GSE17025 dataset from the GEO database was analyzed via the limma package to identify differentially expressed genes (DEGs) in EC.

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Objective: Tolerogenic dendritic cells (tolDCs) have emerged as a potential treatment for rheumatoid arthritis (RA). However, the detailed mechanism requires further investigation. In this study, we aimed to explore the effects of tolDCs on T-cell differentiation and NLRP3-mediated pyroptosis in a collagen-induced arthritis (CIA) rat model.

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Article Synopsis
  • Tolerogenic dendritic cells (tolDCs) might help treat rheumatoid arthritis by changing how the immune system responds.
  • In a study with rats, researchers found that tolDCs from male rats could live inside female rats with arthritis and showed up in their lymph nodes and ankle joints.
  • The presence of tolDCs changed levels of certain molecules that control the immune system, with some decreasing and others increasing, indicating they have an effect on the body's immune response.
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Objective: To explore the effect and mechanism of norcantharidin (NCTD) on hematopoiesis function in leucopenia model rat induced by cyclophosphamide (CTX).

Methods: Leucopenia model was replicated in SD rat with cyclophosphamide(CTX) and model animal was treated with NCTD. Peripheral blood and bone marrow tissue samples were collected from the rats in each experimental group.

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