Publications by authors named "Xiude Li"

Breast cancer is the leading cause of cancer-related death and the most common cancer among women worldwide. It is crucial to identify potentially modifiable risk factors to intervene and prevent breast cancer effectively. Sleep factors have emerged as a potentially novel risk factor for female breast cancer.

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Objectives: There are differing opinions and findings about the accuracy of self-reported data. This study sought to assess the accuracy of self-reported height, weight, and waist circumference (WC) data among adult residents in poor, rural areas of China.

Methods: Multi-stage stratified cluster random sampling was used to sample rural adult residents in Jinzhai County.

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This study conducted data on 15,446 adults to explore the impact of flavonoids on weight-adjusted waist index (WWI). This was a nationwide cross-sectional study among US adults aged 20 years or older. Dietary intake of flavonoids was assessed through 24-h recall questionnaire.

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Background & Aims: Previous studies have shown that plant-rich dietary patterns, such as the Mediterranean diet, are associated with longer telomeres. However, no association has been found between vegetarian diet and telomere length. We hypothesized that the quality of plant-based diets plays an important role in telomere length.

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Objective: Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations between inflammatory dietary pattern and the odds of hepatic steatosis and fibrosis.

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Article Synopsis
  • Lean individuals can develop hepatic steatosis, but their metabolic and risk profiles differ compared to non-lean individuals, prompting this study to explore these characteristics.
  • In a study of 1610 patients, lean individuals had a lower degree of fibrosis and lower rates of diabetes, dyslipidemia, and hypertension, as well as healthier cholesterol and insulin levels.
  • Interestingly, specific risk factors like being Hispanic and alcohol consumption showed varying associations with lean versus non-lean steatosis, highlighting the complexity and potential distinct causes behind these conditions.
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The aging population and high incidence of age-related diseases are major global societal issues. Consuming bioactive substances as part of our diet is increasingly recognized as essential for ensuring a healthy life for older adults. Wheat germ protein has a reasonable peptide structure and amino acid ratio but has not been fully utilized and exploited, resulting in wasted wheat germ resources.

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Purpose: Plant-based diets, particularly when rich in healthy plant foods, have been associated with a lower risk of type 2 diabetes and cardiovascular disease. However, the impact of plant-based diets that distinguish between healthy and unhealthy plant foods on cardiometabolic biomarkers remains unclear.

Methods: Dietary information was collected by two 24-h recalls among 34,785 adults from a nationwide cross-sectional study.

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The association between time-restricted eating (TRE) and the risk of non-alcoholic fatty liver disease (NAFLD) is less studied. Moreover, whether the association is independent of physical exercise or diet quality or quantity is uncertain. In this nationwide cross-sectional study of 3813 participants, the timing of food intakes was recorded by 24-h recalls; NAFLD was defined through vibration-controlled transient elastography in the absence of other causes of chronic liver disease.

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Epidemiological research has demonstrated that the increase in high fat consumption has promoted the morbidity of diabetes. Exposure to organophosphorus pesticides (such as chlorpyrifos) may also increase the risk of diabetes. Although chlorpyrifos is a frequently detected organophosphorus pesticide, the interaction effect between chlorpyrifos exposure and a high-fat diet on glucose metabolism is still unclear.

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The effects of interactions between the toxic and essential metal mixtures on cognitive function are poorly understood. This study aims to identify the joint association of arsenic (As), cadmium (Cd), and lead (Pb) with cognitive function in older adults and the moderating role of selenium (Se), zinc (Zn), and copper (Cu) in this association. This study included 1000 community-dwelling older adults.

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Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and glucoraphanin, which could be converted into SFN in the intestine.

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Article Synopsis
  • The study examines the health impacts of starchy versus non-starchy vegetables on mortality risk using data from a large cohort of over 40,000 participants.
  • Daily consumption of non-starchy vegetables was linked to a significant decrease in mortality risk, while starchy vegetables showed only a weak association.
  • The research suggests that non-starchy vegetables may be more beneficial for health, with optimal intake levels for risk reduction being around 200 grams per day for non-starchy and 300 grams per day for total vegetables.
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There is little evidence for the associations of the overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI) with the odds of nonalcoholic fatty liver disease (NAFLD). We present a nationwide cross-sectional study among US adults aged 18 years or older. Diet was assessed by 24-h recalls.

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Previous studies have reported inconsistent associations between low-carbohydrate diets (LCD) and plasma lipid profile. Also, there is little evidence on the role of the quality and food sources of macronutrients in LCD in cardiometabolic health. We investigated the cross-sectional associations between LCD and plasma cardiometabolic risk markers in a nationwide representative sample of the US population.

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Objective: This study assessed the cross-sectional associations of low-carbohydrate diets (LCDs) and low-fat diets (LFDs) with hepatic steatosis in the National Health and Nutrition Examination Survey.

Methods: Diet was measured using the 24-hour recalls. Hepatic steatosis was defined by vibration-controlled transient elastography.

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Background: Acrylamide is formed during food heating and is neurotoxic to animals and potentially carcinogenic to humans. It is important to reduce acrylamide content during food processing. Researchers have suggested that garlic powder could reduce acrylamide content, but the key substance and acrylamide reduction pathway of garlic powder was unclear.

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The complexation of protein and polysaccharide has shown considerable potential for the encapsulation of functional food components. In this work, propylene glycol alginate (PGA) molecules with different molecular weights (100, 500, and 2,000 kDa) were prepared through HO oxidation, which were further combined with β-lactoglobulin nanoparticles (β-lgNPs) to form PGA-β-lgNPs complexes for the delivery of curcumin (Cur). Results showed that the depolymerization of PGA molecule was resulted from the breakage of glycosidic bonds in the main chain, and the depolymerization rate of PGA molecule depended on the reaction time, temperature, solution pH and HO concentration.

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Article Synopsis
  • - The study investigates the relationship between essential trace elements (ETEs) and atherosclerotic cardiovascular disease (ASCVD) risks in older Chinese adults, focusing on individual ETEs and their mixture over a span of 10 years.
  • - A total of 607 participants had their blood levels of specific ETEs (like chromium and selenium) measured to determine their impact on ASCVD risks, using established predictive equations and statistical models.
  • - Results indicated that higher blood levels of chromium and selenium correlate with lower ASCVD risks, along with positive associations with healthy cholesterol levels and negative associations with blood pressure.
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Background: Current dietary guidelines generally treat all types of vegetables the same. However, whether specific vegetables are more beneficial or deleterious for preventing chronic liver disease (CLD) remains uncertain.

Methods: We investigated the associations between starchy and non-starchy vegetables and the odds of hepatic steatosis and fibrosis in a US nationwide cross-sectional study.

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There is little evidence for the association between fruit juice, especially 100% fruit juice, and mortality risk. In addition, whether 100% fruit juice can be a healthy alternative to whole fruit remains uncertain. This prospective study utilized the data from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014.

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Although antibiotic exposure in the general population has been well documented by a biomonitoring approach, epidemiologic data on the relationships between urinary antibiotic burden in the elderly with blood pressure (BP) are still lacking. The current study revealed thirty-four antibiotics in urine specimens from 990 elderly patients in Lu'an City, China, with detection frequencies ranging from 0.2 to 35.

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Article Synopsis
  • The study explored how carbohydrate intake impacts overall and specific-cause mortality in a large group of participants over a median of 7.1 years.
  • Higher fiber intake correlated with a lower risk of death, while the overall carbohydrate intake did not show significant associations.
  • Substituting carbohydrates with plant-based fats and proteins reduced the risk of total and cardiovascular-related deaths, while a higher carbohydrate-to-fiber ratio increased the risk of overall and cancer-specific mortality.
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  • The study investigates the link between phthalate exposure, specifically Mono (2-ethylhexyl) phthalate (MEHP), Mono benzyl phthalate (MBzP), and Mono butyl phthalate (MBP), and depressive symptoms in the elderly.
  • Using a sample of 989 elderly participants, researchers measured phthalate levels in urine and inflammatory factors in blood, finding a positive association between high phthalate levels and increased depressive symptoms.
  • Chronic inflammation was identified as a partial mediator in the relationship between MEHP exposure and depressive symptoms, suggesting that inflammation may play a role in how phthalates contribute to depression among older adults.
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Synopsis of recent research by authors named "Xiude Li"

  • - Xiude Li's research focuses on the relationship between dietary patterns, nutritional components, and chronic health conditions, particularly concerning liver disease, metabolic health, and cognitive function among various populations.
  • - Recent studies highlight how flavonoid intake and plant-based diets can influence metabolic markers and outcomes such as waist size, telomere length, and cardiometabolic risk, suggesting that the quality of diet plays a significant role in health.
  • - Additionally, Li's work investigates the effects of environmental factors, such as exposure to toxic metals and pesticides, on health outcomes, elucidating the potential protective roles of nutrients like selenium against cognitive decline and diabetes.

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