Multi-omics analysis of oral bacterial biofilm on titanium oxide nanostructure modified implant surface: sequencing-based pilot study in beagle dogs.

Peri-implantitis, the major cause of implant failure, is an inflammatory destructive disease due to the dysbiotic polymicrobial communities at the peri-implant sites. Therefore, it is highly warranted to develop the implant materials with antimicrobial properties and investigate their effects on oral microbiota. However, most of the relevant studies were performed , and insufficient to provide the comprehensive assessment of the antimicrobial capacity of the implant materials .

Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells.

Background: Selective laser melting (SLM) titanium is an ideal option to manufacture customized implants with suitable surface modification to improve its bioactivity. The peri-implant soft tissues form a protective tissue barrier for the underlying osseointegration. Therefore, original microrough SLM surfaces should be treated for favorable attachment of surrounding soft tissues.

Enhanced antibacterial efficacy of selective laser melting titanium surface with nanophase calcium phosphate embedded to TiO nanotubes.

Selective laser melting (SLM) has promising prospects in manufacturing customized implants, however the rough surface of SLM titanium specimen can facilitate bacterial adherence and biofilm formation, which is a risk to implant success. Therefore, surface modification is required to enhance its antibacterial efficacy. Sandblasting, anodization and electrochemical deposition were applied to construct a novel composite nanostructure of nanophase calcium phosphate embedded to TiO nanotubes on microrough SLM titanium substrates (NTN).

Clinical Outcomes of Bicortical Engagement Implants in Atrophic Posterior Maxillae: A Retrospective Study with 1 to 5 Years Follow-up.

Bicortical dental implantation technique was regarded as an alternative to internal sinus lift technique with bone grafting in dental implantation in atrophic maxillae. The purpose of this retrospective study was to evaluate the survival rates and bone stability of 6- and 10-mm implants in the posterior maxilla using bicortical dental implantation techniques after 1 to 5 years of prosthetic loading. A total of 53 patients received posterior maxillary implant treatments.

Influence of Lateral-Medial Sinus Width on No-Grafting Inlay Osteotome Sinus Augmentation Outcomes.

Purpose: Intrasinus new bone formation (BF) has been observed after no-grafting osteotome sinus augmentation, and it is hypothesized to be influenced by the dimensions of the maxillary sinus. The aim of this clinical trial is to evaluate the influence of lateral-medial sinus width (SW) on no-grafting osteotome sinus augmentation outcomes using cone-beam computed tomography.

Patients And Methods: All patients recruited for this prospective study were treated with no-grafting osteotome sinus augmentation with simultaneous implant placement.

Improved performance of collagen scaffolds crosslinked by Traut's reagent and Sulfo-SMCC.

Collagen scaffolds are frequently employed for applications in regenerative medicine. In previous studies, we affirmed that Traut's reagent (2-Iminothiolane hydrochloride) and Sulfo-SMCC (4-(N-Maleimidomethyl) cyclohexane-1-carboxylic acid 3-sulpho-N-hydroxysuccinimide ester sodium salt) could covalently bind growth factors on collagen scaffolds. We also observed that crosslinking formed within the collagen scaffolds with excess dosage of Sulfo-SMCC, which improved the biological performance of collagen scaffolds together with growth factors.