Improved health outcomes of nasopharyngeal carcinoma patients 3 years after treatment by the AI-assisted home enteral nutrition management.

Objectives: Patients with nasopharyngeal carcinoma (NPC) are prone to malnutrition, which leads to deterioration of health. This study is to clarify the effect of Artificial intelligence (AI)-assisted home enteral nutrition (HEN) management mode on the health status of patients with stage III to stage IV NPC after 3 years of treatment, and to provide a new strategy for improving the quality of life of patients.

Methods: Patients with stage III ~ IV NPC were determined whether to accept AI-assisted HEN management according to voluntary principle.

Effects of Cooling Media on Microstructure and Mechanical Properties in Friction Stir Welded SA516 Gr.70 Cryogenic Steel Joints.

SA516 Gr.70 steels were welded by friction stir welding (FSW) under various media of air, water, and water + CO cooling, and the effect of the cooling media on the microstructure and mechanical properties of joints was systematically analyzed. The nugget zone (NZ) under the air-cooling condition contained coarse bainite + martensite.

CAR-NK Cell Therapy: A Transformative Approach to Overcoming Oncological Challenges.

The use of chimeric antigen receptor (CAR) in natural killer (NK) cells for cancer therapy is gaining momentum, marking a significant shift in cancer treatment. This review aims to explore the potential of CAR-NK cell therapy in cancer immunotherapy, providing a fresh perspective. It discusses the innovative approaches in CAR-NK cell design and engineering, particularly targeting refractory or recurrent cancers.

Support mechanical response analysis and surrounding rock pressure calculation method for a shallow buried super large section tunnel in weak surrounding rock.

At present, China's demand for high-speed railway construction is constantly increasing, and the construction of Multi line high-speed railway tunnels has been put on the agenda. The design and construction issues of super-large-sections tunnels urgently need to be addressed. The Xiabei mountain No.

3D Vessel Segmentation With Limited Guidance of 2D Structure-Agnostic Vessel Annotations.

Delineating 3D blood vessels of various anatomical structures is essential for clinical diagnosis and treatment, however, is challenging due to complex structure variations and varied imaging conditions. Although recent supervised deep learning models have demonstrated their superior capacity in automatic 3D vessel segmentation, the reliance on expensive 3D manual annotations and limited capacity for annotation reuse among different vascular structures hinder their clinical applications. To avoid the repetitive and costly annotating process for each vascular structure and make full use of existing annotations, this paper proposes a novel 3D shape-guided local discrimination (3D-SLD) model for 3D vascular segmentation under limited guidance from public 2D vessel annotations.

Clinical and genetic analysis of 18 patients with mutations from South China.

Background: We aimed to delineate the genotype and phenotype of patients with KCNQ2 mutations from South China.

Methods: Clinical manifestations and characteristics of KCNQ2 mutations of patients from South China were analyzed. Previous patients with mutations detected in this study were reviewed.

Multifaceted physiological and therapeutical impact of curcumin on hormone-related endocrine dysfunctions: A comprehensive review.

Over the past five decades, Curcumin (Cur), derived from turmeric (Curcuma longa), has gained considerable attention for its potential therapeutic applications. Synthesizing insights from clinical trials conducted over the last 25 years, this review delves into diseases where Cur has demonstrated promise, offering a nuanced understanding of its pharmacokinetics, safety, and effectiveness. Focusing on specific examples, the impact of Cur on various human diseases is explored.

Clinical effects of atorvastatin combined with conbercept in the treatment of patients with macular edema secondary to retinal vein occlusion and carotid plaque: study protocol for a prospective randomized controlled trial.

Introduction: Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs have been widely used in patients with macular edema (ME) secondary to retinal vein occlusion (RVO); however, recurrence is a major concern. This study aims to observe the clinical effects of atorvastatin and intravitreal therapy in the treatment of patients with branch or central RVO-ME and coexistent carotid plaques (CP).

Methods And Analysis: A prospective randomized controlled clinical trial will be conducted.

[Correlation between clinical phenotypes and genotypes among 46 children with SCN1A-related developmental epileptic encephalopathy].

Objective: To explore the correlation between clinical phenotypes and genotypes among 46 children with SCN1A-related developmental epileptic encephalopathy (DEE).

Methods: Clinical data of 46 children with DEE and SCN1A variants identified at the Guangzhou Women and Children's Medical Center between January 2018 and June 2022 were collected. The children were grouped based on their age of onset, clinical manifestations, neurodevelopmental status, and results of genetic testing.

PathoGraph: An Attention-Based Graph Neural Network Capable of Prognostication Based on CD276 Labelling of Malignant Glioma Cells.

Computerized methods have been developed that allow quantitative morphological analyses of whole slide images (WSIs), e.g., of immunohistochemical stains.

Impact of litter size on the hematological and iron status of gilts, sows and newborn piglets: a comparative study of domestic pigs and wild boars.

Background: The critically low hepatic iron stores of newborn piglets are considered to be a major cause of neonatal iron deficiency in modern breeds of domestic pig (Sus domestica). The main factor believed to contribute to this phenomenon is large litter size, which has been an objective of selective breeding of pigs for decades. As consequence, iron transferred from the pregnant sow has to be distributed among a greater number of fetuses.

Enhanced Toughness and Ductility of Friction Stir Welded SA516 Gr.70 Steel Joint via Post-Welding Annealing.

The SA516 Gr.70 steel possessing excellent toughness and plasticity has been widely used in the cryogenic field. However, the appearance of coarse bainite in the heat affected zone (HAZ) of the fusion welded joint deteriorates the toughness and ductility.

MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5.

Despite being the subject of multiple cancer studies, nothing is known about miR-597-5p's role in colitis-associated colorectal cancer (CAC). We intend to explore how miR-597-5p influences the growth and development of CAC. In order to construct a CAC model, mice were stimulated with azoxymethane (AOM)/dextran sulfate sodium (DSS).

Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy.

Introduction: Self-limited infantile epilepsy (SeLIE) is a benign epilepsy. Previous studies have shown that monotherapy with most antiseizure medications can effectively relieve seizures in patients with SeLIE, but the efficacy of levetiracetam has not been investigated.

Objective: This study aimed to investigate the efficacy of levetiracetam in the treatment of SeLIE patients with PRRT2 mutations.

[Genetic analysis of a child with developmental disorder and epilepsy due to a homozygous variant of PIGW gene].

Objective: To explore the genetic basis for a child featuring global developmental disorder with epilepsy.

Methods: A child who had presented at Guangzhou Women and Children's Medical Center in July 2022 was selected as the study subject. Clinical data was collected.

Unsupervised Local Discrimination for Medical Images.

Contrastive learning, which aims to capture general representation from unlabeled images to initialize the medical analysis models, has been proven effective in alleviating the high demand for expensive annotations. Current methods mainly focus on instance-wise comparisons to learn the global discriminative features, however, pretermitting the local details to distinguish tiny anatomical structures, lesions, and tissues. To address this challenge, in this paper, we propose a general unsupervised representation learning framework, named local discrimination (LD), to learn local discriminative features for medical images by closely embedding semantically similar pixels and identifying regions of similar structures across different images.

Effect of sedated colonoscopy with different cost coverage on improving compliance with colorectal cancer screening in China.

Background: Colorectal cancer is the third most common cancer worldwide. Colonoscopy is the gold standard for colorectal cancer screening. However, the colonoscopy participation rate in China is much lower than that in Europe and the United States.

Necroptosis Mediates Muscle Protein Degradation in a Cachexia Model of Weanling Pig with Lipopolysaccharide Challenge.

Necroptosis, an actively researched form of programmed cell death closely related to the inflammatory response, is important in a variety of disorders and diseases. However, the relationship between necroptosis and muscle protein degradation in cachexia is rarely reported. This study aimed to elucidate whether necroptosis played a crucial role in muscle protein degradation in a cachexia model of weaned piglets induced by lipopolysaccharide (LPS).

Freeze-dried powder of daylily bud improves bromocriptine-induced lactation disorder in rats via JAK2/STAT5 pathway.

Ethnopharmacological Relevance: Milk deficiency is a prevalent problem in the world. Daylily (Hemerocallis citrina Borani), called the Chinese mother flower, is a traditional vegetable and is believed to possess a galactagogue effect in China. Flavonoids and phenols are considered as the active ingredients of daylily to promote lactation and improve depression.

A comparative study of structural parameters for spiral groove bearing in centrifugal rotary blood pump.

In this work, the hydrodynamic characteristics of spiral groove bearing in centrifugal rotary blood pump is investigated for the cases with different structural parameters. The simulation model is proposed based on the CFD technology and the effectiveness of simulation model is demonstrated by the published data. Then, the pressure, load carrying capacity and friction torque are calculated and the characteristics of pressure distribution are analyzed.