Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study.

Objective: The relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL).

Methods: This cross-sectional study was conducted among a population of outpatients diagnosed with ARHL at four medical centers in different regions of China, from June 2020 to June 2023.

ADT Network: A Novel Nonlinear Method for Decoding Speech Envelopes From EEG Signals.

Decoding speech envelopes from electroencephalogram (EEG) signals holds potential as a research tool for objectively assessing auditory processing, which could contribute to future developments in hearing loss diagnosis. However, current methods struggle to meet both high accuracy and interpretability. We propose a deep learning model called the auditory decoding transformer (ADT) network for speech envelope reconstruction from EEG signals to address these issues.

Phosphorus adsorption characteristics and release risk in saline soils: a case study of Songnen Plain, China.

Introduction: The Songnen Plain is one of the three major saline-alkali areas in China, covering a vast area, where drought and overgrazing have exacerbated the salinization trend, and will have great potential for development if utilized rationally. Phosphorus, as one of important soil nutrients, plays a crucial role in plant growth. How to minimize its loss and migration has become a current research hotspot.

Effects of aging methods on the adsorption of antibiotics in wastewater by soybean straw biochar.

Background: The environmental pollution and ecological risks caused by the widespread use of antibiotics have attracted attention in recent years. Biochar materials have a rich pore diameter and can effectively adsorb pollutants from wastewater. However, biochar will experience high temperatures, freezing and thawing in nature, affecting its physicochemical properties and adsorption capacity.

Investigation on the interaction of aromatic organophosphate flame retardants with human serum albumin via computer simulations, multispectroscopic techniques and cytotoxicity assay.

Organophosphate flame retardants (OPFRs) are newly emerging estrogenic environmental pollutants, which attracted widespread public interest owing to their potential threats to human. Here, the interaction between two typical aromatic OPFRs, TPHP/EHDPP and HSA was researched by different experiments. Experimental results indicated that TPHP/EHDPP can insert the site I of HSA and be encircled by several amino acid residues, Asp451, Glu292, Lys195, Trp214 and Arg218 played vital roles in this binding process.

Mitophagy in ototoxicity.

Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways. The results of ototoxicity models indicate the importance of this process in the etiology of ototoxicity.

Diagnosis, differential diagnosis, and treatment for sudden sensorineural hearing loss: Current otolaryngology practices in China.

Introduction: Although sudden sensorineural hearing loss (SSNHL) has been attempted to be understood for 70 years, diagnosis and treatment strategies still have strong heterogeneity worldwide, which are reflected in the guidelines issued by countries and the clinical practice of otolaryngologists.

Methods: Questionnaires were sent to registered otolaryngologists nationwide an online questionnaire system. We investigated the current views and clinical practices of otolaryngologists in mainland China about the diagnosis, examination, and treatment strategies of SSNHL.

Herbal medicines in the treatment of tinnitus: An updated review.

Tinnitus is perception of sound in the absence of an apparent external acoustic stimulus. The condition is prevalent in adults, especially the elderly (≥65 years), and may be associated with cognitive function decline and significantly impacts on the quality of life, heralding difficulties in managing this challenging disorder. Interventions for tinnitus have been varied.

Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear.

Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over five million people around the world have suffered from middle ear cholesteatoma. The annual incidence of middle ear cholesteatoma has been reported to be 9.

Cisplatin-induced ototoxicity: From signaling network to therapeutic targets.

Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion degeneration, and hair cell death. Over several decades, the research scope of cisplatin-induced ototoxicity has expanded with the discovery of the molecular mechanism mediating inner ear cell death, highlighting the roles of reactive oxygen species and transport channels for cisplatin uptake into inner ear cells.

Adsorption of norfloxacin from wastewater by biochar with different substrates.

The type of feedstock and pyrolysis temperature are the main reasons affecting the properties of the resulting biochar. Therefore, this paper investigates the effects of different feedstocks (peanut shell, corn straw and soybean straw) and different pyrolysis temperatures (300, 450 and 600 ℃) on the structural morphology and elemental composition of the resulting biochar. The optimum pyrolysis temperature of 600 ℃ was selected based on the comparison of the adsorption of NFX (norfloxacin) by the biochar prepared at different temperatures.

A Questionnaire-Based Ensemble Learning Model to Predict the Diagnosis of Vertigo: Model Development and Validation Study.

Background: Questionnaires have been used in the past 2 decades to predict the diagnosis of vertigo and assist clinical decision-making. A questionnaire-based machine learning model is expected to improve the efficiency of diagnosis of vestibular disorders.

Objective: This study aims to develop and validate a questionnaire-based machine learning model that predicts the diagnosis of vertigo.

MiR-508-3p promotes proliferation and inhibits apoptosis of middle ear cholesteatoma cells by targeting PTEN/PI3K/AKT pathway.

Cholesteatoma of the middle ear is a common disease in otolaryngology, which can lead to serious intracranial and extracranial complications. Recent studies showed that the dysregulation of microRNA may be involved in the formation of middle ear cholesteatoma. This study aimed to explore the regulatory effect of micro ribonucleic acid 508-3p () on proliferation and apoptosis of middle ear cholesteatoma cells and excavate its underlying regulatory mechanism.

Melatonin protects cochlear hair cells from nicotine-induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress.

Hearing loss positively links with cigarette smoking. However, the involved mechanism and treatment strategies are largely unrevealed. This study aimed to investigate the damaging effect of nicotine on cochlear hair cells, reveal the underlying mechanism and evaluate the therapeutic effect of melatonin on nicotine-induced injury.

Retracted: Family planning services use: A shared responsibility between men and women of reproductive age in Hubei province, China.

Objective: Effective use of family planning (FP) services significantly improves sexual and reproductive health of both women and men. Recently, the Chinese government has launched the two-child policy allowing families to have an additional child. This study aimed to explore the population's interest for FP services, unmet needs, and expectations.

Icariin Treatment Protects Against Gentamicin-Induced Ototoxicity via Activation of the AMPK-SIRT3 Pathway.

Ototoxicity is a serious health problem that greatly affects millions of people worldwide. This condition is caused by the entry of aminoglycosides into auditory hair cells, subsequently inducing reactive oxygen species (ROS) production and accumulation. Several strategies have been adopted to overcome irreversible ROS-induced hair cell loss in mammals.

Development of a Novel Multiple Cross-Linking Spiral Amplification for Rapid and Sensitive Detection of HPV16 DNA.

PCRThere has been increasing interest in the head and neck squamous cell carcinoma (HNSCC) that is caused by high-risk human papillomavirus (HR-HPV) and has posed a significant challenge to Otolaryngologists. A rapid, sensitive, and reliable method is required for the detection of HR-HPV in clinical specimens to prevent and treat HPV-induced diseases. In this study, a multiple cross-linking spiral amplification (MCLSA) assay was developed for the visual detection of HPV-16.

Biodegradation of Atrazine by Mixed Bacteria of Klebsiella variicola Strain FH-1 and Arthrobacter sp. NJ-1.

The purpose of this study is to enhance the biodegradability of atrazine with FH-1 and NJ-1 alone by selecting the mixing ratio, optimizing the culture medium and conditions. The results showed that FH-1 and NJ-1 have the best biodegradation effect on atrazine being mixed in a volume ratio of 3:2. In a single factor experiment, sucrose and NHCl provided carbon and nitrogen sources for the mixed bacteria.

Effects of different agronomic practices on the selective soil properties and nitrogen leaching of black soil in Northeast China.

Considering the large amount and high frequency application of concentrated fertilizer nitrogen in the Black Soil Region of Northeast China, the current laboratory/field simulation study aimed to explore the pollution risk of added nitrogen in black soil to groundwater and identify effective measures to prevent and control soil nitrogen leaching with an undisturbed soil column. The results showed that the saturated nitrogen adsorption capacities increased by 1.7%, 7.

Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling .

Aminoglycoside-induced ototoxicity can have a major impact on patients' quality of life and social development problems. Oxidative stress affects normal physiologic functions and has been implicated in aminoglycoside-induced inner ear injury. Excessive accumulation of reactive oxygen species (ROS) damages DNA, lipids, and proteins in cells and induces their apoptosis.

[The myxoma and bony mass in the middle ear: a case report].

The main clinical manifestations of the tumors in the middle ear are hearing loss, intact tympanic membrane, and conductive hearing damage. CT shows soft tissue lesions and abnormal bony lesions in the middle ear. The tumors were completely removed by operation and confirmed by pathology as myxoma and bony structure tumor.

Study on influencing factors and mechanism of removal of Cr(VI) from soil suspended liquid by bentonite-supported nanoscale zero-valent iron.

In order to clarify the mechanism and effect of bentonite-supported nanoscale zero-valent iron (nZVI@Bent) on Cr(VI) removal in soil suspended liquid, nZVI@Bent was prepared by liquid-phase reduction method in this research. A number of factors, including the mass ratio of Fe to bentonite during preparation of nZVI@Bent, nZVI@Bent dosage, soil suspended liquid pH value and reaction temperature were assessed to determine their impact on the reduction of Cr(VI) in soil suspended liquid. The nZVI@Bent was characterized by scanning electron microscope (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) to analyze the mechanism of removal of Cr(VI) from the soil.

Preparation of TiO-modified Biochar and its Characteristics of Photo-catalysis Degradation for Enrofloxacin.

In order to solve the problem that the traditional biochar(BC) has insufficient removal ability of enrofloxacin and TiO is difficult to recycle. In this study, TiO-modified biochar composites were prepared by impregnation method. Through characterization analysis, The BET specific surface area results indicated that after loading TiO, the specific surface area of TiO-biochar(Ti-BC), TiO-ironized biochar(Ti-FBC) and TiO-alkaline biochar(Ti-KBC) increased by 4.

RNA-seq Profiling and Co-expression Network Analysis of Long Noncoding RNAs and mRNAs Reveal Novel Pathogenesis of Noise-induced Hidden Hearing Loss.

Noise-induced hidden hearing loss (NIHHL), one of the family of conditions described as noise-induced hearing loss (NIHL), is characterized by synaptopathy following moderate noise exposure that causes only temporary threshold elevation. Long noncoding RNAs (lncRNAs) mediate several essential regulatory functions in a wide range of biological processes and diseases, but their roles in NIHHL remain largely unknown. In order to determine the potential roles of these lncRNAs in the pathogenesis of NIHHL, we first evaluated their expression in NIHHL mice model and mapped possible regulatory functions and targets using RNA-sequencing (RNA-seq).