Publications by authors named "Xiu-yin Wu"
Article Synopsis
- Three new alkaloids and sixteen known alkaloids were identified from the bulbs of Narcissus tazetta subsp. chinensis, with their structures determined using various spectroscopic methods.
- Eleven of these alkaloids were found to have immunosuppressive effects on human T cell proliferation, with (+)-narciclasine showing the strongest activity at an IC value of 14 ± 5 nM.
- In lab studies, (+)-narciclasine inhibited NF-κB signaling but didn’t affect PI3K/AKT signaling, and it also reduced liver damage in a mouse model of autoimmune hepatitis.
Article Synopsis
- * These compounds were tested for their effects on human T cell proliferation, with a notable focus on the compound Rhazinilam, which showed significant inhibition without causing harm to T cells.
- * Rhazinilam induced G/M phase arrest in T cells and decreased the production of proinflammatory cytokines, suggesting potential therapeutic applications in immunosuppression.
[Expression and significance of P75 neurotrophin receptor in oral squamous cell carcinoma].
Shanghai Kou Qiang Yi Xue
August 2011
Article Synopsis
- This study explores the role of P75NTR in oral squamous cell carcinoma (OSCC) to determine its potential as a prognostic indicator and a marker for cancer stem cells.
- Using immunohistochemical methods, researchers analyzed P75NTR expression in a tongue cancer cell line and tissue samples from OSCC patients, comparing them to normal and peri-carcinoma tissues.
- Results show high P75NTR expression in a majority of OSCC cases, with a significant association with tumor stage and lymph node metastasis, suggesting it can help predict OSCC prognosis, but more research is needed to understand its exact role in cancer biology.