Preparation, characterization, and evaluation of glycyrrhetinic acid-mediated nano-drug delivery system co-loaded with syringopicroside and hydroxytyrosol.

This study aimed to create a glycyrrhetinic acid (GA)-mediated, multi-component, self-assembled nano-drug delivery system co-loaded with syringopicroside (S) and hydroxytyrosol (H) obtained from by synthesizing a GA-polyethylene glycol-poly (lactic acid-co-glycolic acid) (GPP) nanoparticle delivery carrier to actively target the liver. The nanoparticles were optimized using the central composite design. Nanoparticle characterization, cytotoxicity, pharmacodynamics, and tissue distribution study were performed.

Anti-inflammatory effect and antihepatoma mechanism of carrimycin.

Background: New drugs are urgently needed for the treatment of liver cancer, a feat that could be feasibly accomplished by finding new therapeutic purposes for marketed drugs to save time and costs. As a new class of national anti-infective drugs, carrimycin (CAM) has strong activity against gram-positive bacteria and no cross resistance with similar drugs. Studies have shown that the components of CAM have anticancer effects.

A novel strategy against hepatitis B virus: Glycyrrhetnic acid conjugated multi-component synergistic nano-drug delivery system for targeted therapy.

It is well known that Glycyrrhetnic acid (GA) has significant liver-targeting and anti-inflammatory effects. Syringopicroside (SYR) and Hydroxytyrosol (HT), the active components of the Chinese herb Lindl, have earned great reputation for their potential in preventing or treating viral hepatitis type B. Therefore, we loaded SYR and HT into GA-conjugated PEG-PLGA, so that they could target the liver in additional to exerting their own pharmacological effects in a synergistic.

Insights into the highly efficient treatment of dyeing wastewater using algal bloom derived activated carbon with wide-range adaptability to solution pH and temperature.

Here, a low-cost acid-base and temperature tolerant algal bloom derived activated carbon (ABAC) was successfully prepared to remove rhodamine B (RhB) from water. The ABAC exhibited maximum adsorption capacity of RhB (1101 ± 11 mg/g), higher than that of laboratory-prepared rape straw activated carbon (176 ± 5 mg/g) and commercial activated carbon (489 ± 5 mg/g). It is attributed to larger surface area and mesoporous structure of the ABAC.

Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer.

Background: Norcantharidin (NCTD) is suitable for the treatment of primary liver cancer, especially early and middle primary liver cancer. This compound can reduce tumors and improve immune function. However, the side effects of NCTD have limited its application.

Particle electrode materials dependent tetrabromobisphenol A degradation in three-dimensional biofilm electrode reactors.

The completely biological degradation of Tetrabromobisphenol A (TBBPA) contaminant is challenging. Bio-electrochemical systems are efficient to promote electrons transfer between microbes and pollutants to improve the degradation of refractory contaminants. In particular, three-dimensional biofilm electrode reactors (3DBERs), integrating the biofilm with particle electrodes, represent a novel bio-electrochemical technology with superior treatment performances.

A pilot-scale three-dimensional electrochemical reactor combined with anaerobic-anoxic-oxic system for advanced treatment of coking wastewater.

Coking wastewater is highly concentrated and extremely toxic, greatly challenging the treatment technologies. Conventional biological technology such as anaerobic-anoxic-oxic (AO) system is inefficient, since various biological reactions are inhibited by toxicants in coking wastewater. In this work, a pilot-scale three-dimensional electrochemical reactor (3DER) is integrated into the AO system as a pretreatment unit to improve the treatment efficiency of coking wastewater.

[Mechanism of the anthocyanin single component cyanidin-3-O-glucoside inhibiting proliferation and migration of B16-F10 cells].

To study the effects of the anthocyanin single component cyanidin-3-O-glucoside (Cy-3-glu) on the proliferation and migration of mouse melanoma cells and to elucidate the underlying mechanisms, B16-F10 cells were treated with different concentrations of Cy-3-glu. Cell viability was analyzed by a CCK-8 method. Cell migration was determined by the callus scratching technique.

pH dependence of the binding interactions between humic acids and bisphenol A - A thermodynamic perspective.

The wide application of bisphenol A (BPA) leads to the emergence of BPA residuals in natural water environments. Dissolved organic matter (DOM) existed in water can bind with BPA, hence influencing the migration and transformation of BPA in aquatic environments. pH is a crucial factor governing the binding interactions between DOM and BPA.

Co-doping polymethyl methacrylate and copper tailings to improve the performances of sludge-derived particle electrode.

Three-dimensional electrochemical reactor (3DER) is a highly efficient technology for refractory wastewater treatment. Particle electrodes filled between anode and cathode are the core units of 3DER, determining the treatment efficiency of wastewater. However, particle electrodes deactivation due to catalytic sites coverage seriously impedes the continuous operation of 3DER.

A Novel Bristle-Shaped Semi-Dry Electrode With Low Contact Impedance and Ease of Use Features for EEG Signal Measurements.

In this paper, we present a novel soft bristle-shaped semi-dry electrode for electroencephalography (EEG) recording. Because the bristle-shaped structure with electric conductivity could overcome the obstacle of hair and enable direct connection to scalp, the semi-dry electrode could work with drinking water instead of saline water that was widely used in previous semi-dry or water electrodes to improve its convenience. The electrode consisted of conductive bristles and a 3D-printed casing.

Insights into thermodynamic mechanisms driving bisphenol A (BPA) binding to extracellular polymeric substances (EPS) of activated sludge.

Bisphenol A (BPA) in wastewater has high risks of causing biological feminization. During the wastewater treatment process, large amounts of BPA are accumulated in activated sludge. However, the mechanisms of BPA interacted with activated sludge are still unclear.

A novel integrated system of three-dimensional electrochemical reactors (3DERs) and three-dimensional biofilm electrode reactors (3DBERs) for coking wastewater treatment.

Treatment of coking wastewater is a great challenge due to their instinct characteristics of high concentration, complex composition and biological toxicity. In this work, a novel integrated system comprising three-dimensional electrochemical reactors (3DERs) and three-dimensional biofilm electrode reactors (3DBERs) in series is developed for coking wastewater treatment. Results indicate that 79.

Insights into the interactions between triclosan (TCS) and extracellular polymeric substance (EPS) of activated sludge.

Triclosan (TCS) contaminant has aroused wide concerns due to the high risk of converting into toxic dioxin in aquatic environments. During the wastewater treatment process, considerable amounts of TCS are accumulated in activated sludge but the mechanisms are still unclear. Especially, roles of extracellular polymeric substances (EPS), the main components of activated sludge, in TCS removal have never been addressed.

Rapidly probing the interaction between sulfamethazine antibiotics and fulvic acids.

Antibiotics residuals in the environments receive wide concerns due to the high risk of generating antibiotic resistance. Natural organic matters (NOM) existed in the environments are considered to have the capacity of binding with organic contaminants, consequently influencing their speciation and transformation in the natural environments. To assess the migration of antibiotics in the environments, it is crucial to understand the binding mechanisms between NOM and antibiotics, which is still unclear due to the limit of available research methods.

Cascade Reaction of Propargyl Amines with AgSCF, as Well as One-Pot Reaction of Propargyl Amines, AgSCF, and Di- tert-butyl Peroxide: Access to Allenyl Thiocyanates and Allenyl Trifluoromethylthioethers.

An efficient cascade reaction of propargyl amines with AgSCF and KBr is developed, affording allenyl thiocyanates at room temperature in high yields. This transformation proceeds via the in situ formation of isothiocyanate intermediates, followed by a [3,3]-sigmatropic rearrangement. The resulting allenyl thiocyanates bearing 3-(electro-donating phenyl) substitutions without isolation can then be reacted with di- tert-butyl peroxide and AgSCF under reflux to generate novel allenyl trifluoromethylthioether compounds in moderate to good yields via a "one-pot" three-step process.

[Value of CD3CD4 T Cell Count in Prediction of Viral Infection after Hematopoietic Stem Cell Transplantation in Patients Severe Aplastic Anemia].

Objective: To explore the value of CD3CD4 T cell count in prediction of viral infections after allogeneic hematopoietic stem cell transplantation(allo-HSCT) in the patients with severe aplastic anemia(SAA).

Methods: A total of 78 SAA patients with allo-HSCT in Guangzhou First People's Hospital from January 2014 to July 2016 were enrolled in this study. The absolute numbers of CD3CD4T cells were measured by flow cytometry at 1,2,3,6, and 12 month after allo-HSCT.

Plasmonic-induced optical transparency in the near-infrared and visible range with double split nanoring cavity.

Plasmonic-induced optical transparency with double split nanoring cavity is investigated with finite difference time domain method. The coupling between the bright third-order mode of split nanoring with one gap and the dark quadrupole mode of split nanoring with two gaps leads to plasmonic analogue of electromagnetically induced transparency. The transparence window is easily modified to the near-infrared and visible range.

Microstructure and magnetic property of M-type SrRe(x)Fe(12-x)O19 by sol-gel method.

Magnetoplumbite-type (M-type) SrRE(x)Fe(12-x)O19 (RE = La and Ce, x = 0-1.0) powders were prepared by a citric acid sol-gel technique and subsequent heat treatment. The crystal structure, grain size and magnetic properties were investigated by X-ray Diffraction (XRD), Scanning Electron Microscope (SEM) and vibrating sample magnetometer (VSM).