Beneficial effects of endoscopic screening on gastric cancer and optimal screening interval: a population-based study.

BACKGROUND : The effectiveness of endoscopic screening on gastric cancer has not been widely investigated in China and the screening interval of repeated screening has not been determined. METHODS : In a population-based prospective study, we included 375,800 individuals, 14,670 of whom underwent endoscopic screening (2012-2018). We assessed the associations between endoscopic screening and risk of incident gastric cancer and gastric cancer-specific mortality, and examined changes in overall survival and disease-specific survival following screening.

Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer.

Background: Molecular features underlining the multistage progression of gastric lesions and development of early gastric cancer (GC) are poorly understood, restricting the ability to GC prevention and management.

Methods: We portrayed proteomic landscape and explored proteomic signatures associated with progression of gastric lesions and risk of early GC. Tissue proteomic profiling was conducted for a total of 324 subjects.

[Analysis of assessment results of malaria elimination in Suzhou City].

Objective: To analyze the assessment results of malaria elimination in Suzhou City, so as to provide references for consolidating the results of malaria elimination in the city.

Methods: According to "Jiangsu Province Malaria Evaluation and Assessment Implementation Plan (2014 Edition)" and "Jiangsu City Malaria Evaluation Implementation Regulations (2015 Edition)", the assessment of the county-level cities and districts under the jurisdiction of Suzhou City was conducted. After the assessment, the municipal level assessment and evaluation were carried out, and one district was randomly selected for the assessment of malaria elimination review.

[Significant impact of different induction conditions on metabolic diversity of callus cell lines of Glycyrrhiza sp].

The purpose of this study was to evaluate the impact of callus induction and culture conditions on secondary metabolic diversity of the callus cell lines of traditional Chinese medicinal plant Glycyrrhiza sp. (Glycyrrhiza) by combined chemical analysis and HPLC fingerprint. These callus induction conditions included two Glycyrrhiza species, two types of explants, light and dark conditions, and two combinations of hormones.

[Epidemic trend of malaria in Suzhou City, Jiangsu Province, China from 2007 to 2012].

Objective: To understand the epidemic trend of malaria in Suzhou City, Jiangsu Province, so as to provide the evidence for developing the strategies of malaria elimination.

Methods: The malaria information was collected from 2007 to 2012 through the reporting system of Suzhou epidemic information network and parasitic network system, and the results were analyzed statistically.

Results: From 2007 to 2012, there were 318 malaria cases reported.

[Comparison of two gastric cancer screening schemes in a high-risk population].

Objective: To evaluate the effects of two gastric cancer screening schemes for early detection of gastric cancer in a high-risk population.

Methods: A cluster random sampling method was used to select local residents aged 40-69 years from Linqu County, Shandong Province. "Serum pepsinogen initial screening combined with further endoscopic examination (PG scheme)" and "direct endoscopic examination (endoscopy scheme)" were conducted.

[Longitudinal surveillance of intestinal nematodiasis in Yinghu Village of Wujiang City].

Objective: To understand the epidemic dynamics of intestinal nematodiasis in Wujiang City.

Method: The residents of Yinghu Village of Wujiang City were investigated with Kato-Katz technique for the infections of intestinal nematodes, and the persons with the infections were administered with anthelmintics and they also received the health education.

Results: Of the 5 757 residents, 147 persons were infected with intestinal nematodes, with the average infection rate of 2.

Retigeric acid B exerts antifungal effect through enhanced reactive oxygen species and decreased cAMP.

Background: Retigeric acid B (RAB), a triterpene acid isolated from Lobaria kurokawae exerts antifungal effect. The present study was designed to elucidate the underlying mechanisms by which RAB regulates the proliferation and cell death of Candida albicans.

Methods: We measured the metabolic activity of C.

Antifungal macrocyclic bis(bibenzyls) from the Chinese liverwort Ptagiochasm intermedlum L.

Six macrocyclic bis(bibenzyls) were obtained from the Chinese liverwort Ptagiochasm intermedlum L., and their structures were elucidated as pakyonol (1), neomarchantin A (2), isoriccardin C (3), marchantin H (4), riccardin F (5) and riccardin C (6) on the basis of spectroscopic data and comparison with known compounds. Among them, compounds 3-5 were isolated from this liverwort species for the first time.

Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway.

Background: Plagiochin E (PLE) is an antifungal active macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L. To elucidate the mechanism of action, previous studies revealed that the antifungal effect of PLE was associated with the accumulation of ROS, an important regulator of apoptosis in Candida albicans. The present study was designed to find whether PLE caused apoptosis in C.

Plagiochin E, an antifungal bis(bibenzyl), exerts its antifungal activity through mitochondrial dysfunction-induced reactive oxygen species accumulation in Candida albicans.

Background: Plagiochin E (PLE) is an antifungal macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L. Its antifungal mechanism is unknown. To elucidate the mechanism of action, its effect on mitochondria function in Candida albicans was studied.

The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans.

Plagiochin E (PLE), a macrocyclic bis(bibenzyl) isolated from the liverwort Marchantia polymorpha, has been reported to have antifungal activity and resistance reversal effects on Candida albicans. In order to understand the underlying mechanisms, we studied the effects of PLE alone and in combination with fluconazole (FLC) on the ergosterol biosynthetic pathway against both FLC-sensitive and FLC-resistant strains by analyzing the sterol content and the ergosterol pathway gene (ERG) expression. Relative quantitative analysis of different ergosterol precursors was carried out by employing the hyphenated technique of gas chromatography-high resolution mass spectrometry (GC-HR-MS).

Effect of plagiochin E, an antifungal macrocyclic bis(bibenzyl), on cell wall chitin synthesis in Candida albicans.

Aim: To investigate the effect of plagiochin E (PLE), an antifungal macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L, on cell wall chitin synthesis in Candida albicans.

Methods: The effect of PLE on chitin synthesis in Candida albicans was investigated at the cellular and molecular levels. First, the ultrastructural changes were observed under transmission electron microscopy (TEM).