Prenatal Ultrasound Diagnosis of Persistent Hyperplastic Primary Vitreous with Retinoblastoma.

Introduction: Persistent hyperplastic primary vitreous (PHPV) involves a spectrum of congenital ocular abnormalities characterized by the presence of a vascular membrane behind the lens. Retinoblastoma is a life-threatening intraocular malignancy that can cause blindness, eye loss, or even death. PHPV and retinoblastoma are extremely rare prenatal diseases.

Protective effects of upregulated gene against the apoptosis of human retinal pigment epithelial cells .

Aim: To investigate the protective effect of heme oxygenase-1 (HO-1) against HO-induced apoptosis in human ARPE-19 cells.

Methods: The lentiviral vector expressing HO-1 was prepared and transfected into apoptotic ARPE-19 cells induced by HO. Functional experiments including cell counting kit-8 (CCK-8) assay, flow cytometry (FCM) and mitochondrial membrane potential assay were conducted.

Nickel-Iron Dithiolato Hydrides Derived from H Activation by Their μ-Hydroxo Ligand-Containing Analogues.

Here, we describe the synthesis and characterization of the two μ-hydrido models of [NiFe]Hases prepared from a new type of H activation by the corresponding two μ-hydroxo models. In addition, another μ-hydrido model prepared by the anionic exchange between one of the two μ-hydrido models and KPF is also reported. Interestingly, the synthesis of the two μ-hydrido models from H activation represents the first functional modeling of the H activation catalyzed by the [NiFe]Hase (Ni-SIr) state to give the Ni-R state.

Dithiolato-bridged nickel-iron complexes as models for the active site of [NiFe]-hydrogenases.

The structural and functional modeling of the active site of [NiFe]-hydrogenases has been proved to be challenging to a great extent. Herein, we report the synthesis, structures, and some properties of the NiFe-based dicarbonyl, terminal hydride, and μ-hydroxo models for the active site of [NiFe]-hydrogenases.