Implementation and evaluation of an optimized surgical clerkship teaching model utilizing ChatGPT.

Objective: This study aims to explore the effect of an innovative teaching model incorporating ChatGPT on medical students' learning outcomes, compliance with learning activities, and overall satisfaction with the learning process.

Methods: A cohort of 64 students participating in general surgery clerkships at Wenzhou People's Hospital during the 2022-2023 academic year were randomly assigned into 4 groups, each comprising 16 students. Two of these groups were designated as the study group, where ChatGPT was employed as a supplementary educational tool.

Effect of transcutaneous electrical acupoint stimulation at different frequencies on mild hypertension: A randomized controlled trial.

Background: Transcutaneous electrical acupoint stimulation (TEAS) may contribute to blood pressure (BP) control, but the evidence remains insufficient. Our objectives were to evaluate the impact of TEAS on hypertension and determine the optimal frequency.

Methods: A total of 120 hypertensive patients were randomly allocated to the TEAS-2Hz group, TEAS-10Hz group, or usual care control group in a 1:1:1 ratio.

Effects of acupoints-based TENS combined with tDCS on spasticity and motor function in ischemic stroke with spastic hemiplegia: study protocol for a randomized controlled trial.

Background: Spastic hemiplegia following ischemic strokes seriously impedes the recovery of motor function posing a vast rehabilitation challenge. As the uncertain effects of recommended conventional treatments such as botulinum toxin injections on active functional improvement and potential adverse effects cannot be bypassed, there is an increasing need in alternative, more effective and safer modalities. Acupoints-based transcutaneous electrical nerve stimulation (Acu-TENS) and transcranial direct current stimulation (tDCS) are effective non-invasive modalities for stroke rehabilitation, particularly showing anti-spastic effect and functional improvements as well.

[VOCs Emission Level and Emission Reduction Potential of Coating Industry in Zibo].

To evaluate the emission level and emission reduction potential of volatile organic compounds (VOCs) in the coating industry in Zibo, we conducted field research on eight typical enterprises in three representative coating industries:the automobile manufacturing coating industry, wooden furniture coating industry, and metal surface coating industry. The actual measurement method, material balance algorithm, and emission factor method were used to calculate the VOC emissions of enterprises, and the localized emission factors were established. The emission levels of enterprises were evaluated by comparing with other domestic and foreign studies including AP-42, and the emission reduction potential was calculated based on the material balance algorithm.

Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease.

Synaptic dysfunction is an important pathological hallmark and cause of Alzheimer's disease (AD). High-frequency stimulation (HFS)-induced long-term potentiation (LTP) has been widely used to study synaptic plasticity, with impaired LTP found to be associated with AD. However, the exact molecular mechanism underlying synaptic plasticity has yet to be completely elucidated.

Comprehensive analysis of circular RNA-associated competing endogenous RNA networks and immune infiltration in gastric cancer.

Background: Circular RNA (circRNA) has been proved to be an important regulator of gastric cancer (GC). However, the role and regulatory mechanism of circrna related competitive endogenous RNA (ceRNA) in GC have not been established.

Methods: CircRNA data and clinical data were obtained from the GEO and TCGA databases.

[Characteristics and Source Analysis of VOCs Pollution During the Period of Ozone Exceeding the Standard in Zibo City].

In recent years, ozone pollution has been growing increasingly serious in the urban areas of China. Volatile organic compounds (VOCs) are important precursors of O formation, which is of great significance to studying the main characteristics and sources of VOCs for controlling O pollution. In this study, we conducted online VOCs observation in Zibo City from May to September in 2019, monitoring 56 species in total.

[Characteristics of Ozone Pollution and Influencing Factors in Urban and Suburban Areas in Zibo].

In this study, we obtained monitoring data of O and its precursors (NO, VOCs, and CO), as well as meteorological data (temperature, relative humidity, wind speed, and visibility), in 2019 to analyze the characteristics of O pollution and the influencing factors in urban and suburban areas. The results showed that the O episodes accounted for 25.8% of the whole observation period, mostly occurring from May to September.

Assessment of Causal Direction Between Gut Microbiota and Inflammatory Bowel Disease: A Mendelian Randomization Analysis.

Background: Recent studies have shown that the gut microbiota is closely related to the pathogenesis of Inflammatory Bowel Disease (IBD), but the causal nature is largely unknown. The purpose of this study was to assess the causal relationship between intestinal bacteria and IBD and to identify specific pathogenic bacterial taxa via the Mendelian randomization (MR) analysis.

Materials And Methods: MR analysis was performed on genome-wide association study (GWAS) summary statistics of gut microbiota and IBD.

[Emission Characteristics of Volatile Organic Compounds from Typical Industries in Zibo].

To study the emission characteristics of volatile organic compounds (VOCs) in Zibo, nine key industries and their representative enterprises were selected to conduct a field investigation and measurement. The emitted VOC characteristics in different industries were analyzed. Based on measurement data, the emissions of VOCs from all monitored enterprises were calculated to obtain the localization emission factors.

Value of early diagnosis of sepsis complicated with acute kidney injury by renal contrast-enhanced ultrasound.

Background: The incidence of acute kidney injury (AKI) in patients with sepsis is high, and the prognosis of patients with septic AKI is poor. The early diagnosis and treatment of septic AKI is of great significance in improving the prognosis of patients with sepsis.

Aim: To explore the value of contrast-enhanced ultrasound (CEUS), serum creatinine (Scr), and other indicators in the early diagnosis of septic AKI.

Programmable Self-Assembly of Protein-Scaffolded DNA Nanohydrogels for Tumor-Targeted Imaging and Therapy.

DNA hydrogels are biocompatible and are suitable for many biomedical applications. However, to be useful imaging probes or drug carriers, the ordinary bulk size of DNA hydrogels must be overcome. Here we put forward a new strategy for fabricating a novel and simple protein-scaffolded DNA nanohydrogel, constructed through a direct DNA self-assembly using three types of streptavidin (SA)-based DNA tetrad for the activation of imaging and targeting therapy of cancer cells.

[Ozone Formation Potential and Priority Species of VOCs in an Industrial Park].

Ground-level ozone (O) pollution is a serious problem in major cities in China. The control of its precursors, volatile organic compounds (VOCs), is a key to limiting ozone production. The ozone formation potential of VOCs in an industrial park in Tianjin was studied by collecting gas samples at the factory boundaries of six representative enterprises.

Syntheses, crystal structures, adsorption properties and visible photocatalytic activities of highly stable Pb-based coordination polymers constructed by 2-(2-carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline and bridging linkers.

Five highly stable coordination polymers assembled by 2-(2-carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline (2-HNCP) and different aromatic carboxylic acid ligands, namely, [Pb(2-NCP)(L1)]n (1), [Pb2(2-NCP)2(L2)]n·2nH2O (2), [Pb2(2-NCP)2(L2)]n (3), [Pb(2-NCP)(L3)0.5]n (4) and [Pb2(2-NCP)2(L4)]n (5), where HL1 = pyridine-4-carboxylic acid, H2L2 = 2-amino-1,4-benzenedicarboxylic acid, H2L3 = 1,4-benzenedicarboxylic acid and H2L4 = 2-hydroxy-1,4-benzenedicarboxylic acid, have been synthesized under hydrothermal conditions. Their structures have been determined by single crystal X-ray diffraction analyses and further characterized by elemental analyses and infrared spectroscopy.

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint association study of 2 independent genome-wide association meta-analyses of femoral neck and lumbar spine bone mineral densities (BMDs): 1) an in-house study of 6 samples involving 7484 subjects, and 2) the GEFOS-seq study of 7 samples involving 32,965 subjects. The in-house samples were imputed by the 1000 genomes project phase 3 reference panel. SNP-based association test was applied to 7,998,108 autosomal SNPs in each meta-analysis, and for each SNP the 2 association signals were then combined for joint analysis and for mutual replication.

Machine-learning-based classification of real-time tissue elastography for hepatic fibrosis in patients with chronic hepatitis B.

Hepatic fibrosis is a common middle stage of the pathological processes of chronic liver diseases. Clinical intervention during the early stages of hepatic fibrosis can slow the development of liver cirrhosis and reduce the risk of developing liver cancer. Performing a liver biopsy, the gold standard for viral liver disease management, has drawbacks such as invasiveness and a relatively high sampling error rate.

Study on the value of serum miR-106b for the early diagnosis of hepatocellular carcinoma.

Aim: To analyze the incidence of hepatocellular carcinoma (HCC) in a population that underwent health checkups and had high serum miR-106b levels.

Methods: A total of 335 subjects who underwent checkups in the Digestive and Liver Disease Department of our hospital were randomly selected. RT-PCR was used to detect the level of miR-106b in serum samples.

Clinical, demographic and psychological characteristics of infertile male smokers in Northeast China.

Objectives: To investigate clinical, demographic and psychological characteristics of infertile male smokers in northeast China.

Methods: Serum and semen samples were collected from infertile men. Semen analysis was performed according to conventional procedures.

Accuracy of real-time tissue elastography for the evaluation of hepatic fibrosis in patients with chronic hepatitis B: a prospective multicenter study.

Background: The prognosis and management of hepatic fibrosis are closely related to the stage of the disease. The limitations of liver biopsy, which is the gold standard for treatment, include its invasiveness and sampling error. Ultrasound elasticity might be the most promising imaging technology for the noninvasive and accurate assessment of hepatic fibrosis.

[Health risk assessment of VOCs from a furniture mall in Tianjin].

In order to understand the indoor air pollution of volatile organic compounds in furniture mall and to perform health risk assessment of chronic exposure to its workers, in this study, the air samples in a furniture mall in Tianjin were sampled in summer (June) and autumn (October) in 2011 and 2012, and the compositions of VOCs were investigated by using the method of reconcentration-GC-MS. The results showed that the indoor concentration of total pollutants was about 1.9 times higher than that of outdoor; the characterized odorous substances were dichloromethane, toluene, and alpha-pinene; aromatic compounds and halogenated alkane were detected in large amounts in furniture mall, and terpenes also occupied a certain proportion.

[Chemical constituents of chloroform fraction from leaves of Chimonanthus salicifolius].

To explore anti-tumor active components of Chimonanthus salicifolius, the phytochemistry of the chloroform fraction from leaves extract was investigated by repeated silica gel column chromatography. Twelve compounds were isolated and their structures were identified by physicochemical properties and spectroscopic data analysis as 9-epi-blumenol C(1), blumenol C(2), (+)-dehydrovomifoliol (3), (+)-vomifoliol (4), robinlin (5), (-)-loliolide (6), isofraxidin (7), scopoletin (8), 6,7-dimethoxycoumarin (9), 6, 7, 8-trimethoxycoumarin (10), beta-sitostenone (11), and beta-stigmasterol(12). Compounds 1-6 belonging to nor-sesquiterpenoids were isolated from the family Calycanthaceae for the first time.

Poly[[aqua-μ(6)-benzene-1,2,3-tricarboxyl-ato-μ(3)-hydroxido-dizinc] hemihydrate].

In the title compound, {[Zn(2)(C(9)H(3)O(6))(OH)(H(2)O)]·0.5H(2)O}(n), there are three independent Zn(II) atoms present; two are located on special positions, viz a twofold rotation axis and an inversion centre, and the third is located in a general position. The Zn(II) atom on the inversion centre is six-coordinated by four O atoms from four different benzene-1,2,3-tricarboxyl-ate anions and two OH(-) anions.

Effect of intensive blood glucose control on quality of life in elderly patients with type 2 diabetes in Anhui Province.

Background: Intensive blood glucose control is proven to be associated with the diabetic microvascular and macrovascular complications, which could affect quality of life (QOL). This study was performed to determine the effects of intensive glucose control therapy on QOL of elderly patients with type 2 diabetes in Anhui Province.

Methods: Ninety-seven elderly patients with type 2 diabetes in Anhui were randomly assigned to standard treatment group and intensive therapy group.

1-(1H-Imidazo[4,5-f][1,10]phenan-throlin-2-yl)naphthalen-2-ol.

In the title mol-ecule, C(23)H(14)N(4)O, the dihedral angle between the pyridine rings of the phenanthroline unit is 4.43 (8)° and the dihedral angle formed by the nine essentially planar [maximum deviation 0.0389 (16)Å] non-H atoms of the benzimidazole unit and the naphthalene ring system is 74.