Publications by authors named "Xiu-Xiu Shi"
Objective: To compare clinical effects of different postoperative rehabilitation modes on lumbar degenerative diseases, and explore influence of rehabilitation mode and other factors on postoperative effect.
Methods: From June 2013 to July 2016, totally 900 patients were admitted from nine tertiary hospitals in Beijing to perform single segment bone grafting and internal fixation due to lumbar degenerative diseases were prospectively analyzed. There were 428 males and 472 females, the age of patient over 18 years old, with an average of (51.
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, transforming growth factor (TGF)‑β1/2, matrix metalloproteinase (MMP)‑9 and brain‑derived neurotrophic factor (BDNF) in a rat model of LIDD.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) have been shown to be able to inhibit cancer cells growth. In this study, we investigate the role and the molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) in inhibition of cancer cell proliferation by human MSCs through depletion and overexpression of HIF-1α in human MSCs. We found that the cell culture medium from HIF-1α-depleted Z3 cells significantly promotes breast cancer MCF-7 cell proliferation and colony formation.
View Article and Find Full Text PDFArticle Synopsis
- Spinal cord injury (SCI) leads to significant motor and sensory function loss, drastically affecting the quality of life, and this study explores the effects of RAGE deficiency on recovery in a mouse model of SCI.
- The research found that RAGE expression increased after SCI, and mice lacking RAGE showed improved locomotor recovery, reduced tissue damage, and less inflammation following injury.
- RAGE deficiency was linked to decreased apoptosis and oxidative stress, leading to a reduced glial scar formation at the injury site, highlighting RAGE as a potential therapeutic target for enhancing recovery from SCI.