Publications by authors named "Xiu-Wen Zheng"
Article Synopsis
- Trichlorfon can catalyze the oxidation of benzidine to produce 4-amino-4'-nitro biphenyl when combined with sodium perborate, which was confirmed through LC-MS analysis.
- High-performance liquid chromatography (HPLC) was utilized for the separation and quantification of the product, demonstrating a strong linear relationship with trichlorfon concentrations and achieving a low detection limit.
- A new extraction method using sodium dodecyl sulfate (SDS) and solid-phase extraction was developed, improving recovery rates and aligning with the principles of Green Analytical Chemistry by reducing toxic solvent use.
Aim: To study the excretion of (-)-clausenamide in rats.
Methods: The urine, feces and bile were collected at predetermined time points after (-)-clausenamide was orally administrated to 6 rats (30 mg x kg(-1)). The concentrations of (-)-clausenamide and its metabolite 6-OH-(-)-clausnamide were determined by HPLC-MS/MS method using glipzide as the internal reference, and the accumulative excretion amount of (-)-clausenamide and 6-OH-(-)-clausenamide was calculated in the urine, feces and bile, separately.
Aim: To study the four diastereomers of leucogen and structure of the related substances.
Methods: LC-DAD, LC-MS/MS and LC- 1H NMR were used. LC was carried out with a Phenomnex Luna C18 (250 mm x 4.