[Effect of Microplastics and Straw Addition on Nitrogen and Phosphorus Leaching in Orange Orchard Soils].

To explore the effects of microplastic input and straw addition on nitrogen and phosphorus leaching in orange orchard soil, indoor soil column leaching simulation experiments were conducted on orange orchard soil in Dangyang City, Hubei Province. The experiment analyzed the effects of different treatments on the leaching characteristics of soil nitrogen and phosphorus. The results showed that： ① The increase in microplastic input increased the leaching capacity of the soil （TN, NO-N, NH-N, and TP） when only microplastic input was added.

Sulfur-Bridged Co(II)-Thiacalix[4]arene Metal-Organic Framework as an Electrochemical Sensor for the Determination of Toxic Heavy Metals.

A novel sulfur-bridged metal-organic framework (MOF) · based on thiacalix[4]arene derivatives was successfully obtained using a solvothermal method. Remarkably, adjacent ligands were linked via Co(II) cations to form a three-dimensional (3D) microporous architecture. Subsequently, was modified on a glassy carbon electrode () to produce an electrochemical sensor for the detection of heavy-metal ions (HMIs), namely, Cd, Pb, Cu, and Hg, in aqueous solutions.

Naïve B cells with low differentiation improve the immune reconstitution of HIV-infected patients.

Incomplete immune reconstitution happens in some HIV-infected patients who have achieved persistent viral suppression under antiretroviral therapy (ART). We performed single-cell RNA sequencing for peripheral blood mononuclear cells to analyze B cell receptor (BCR) repertoire and B cell subtypes in health controls (non-HIV-infected, HCs), HIV-infected immunological responders (IRs), and immunological nonresponders (INRs). We found that the dominant usage of gene segments of naïve B cells and memory B cells were and , and the diversity of BCR repertoire was decreased in INRs.

Changes in the Mucosa-Associated Microbiome and Transcriptome across Gut Segments Are Associated with Obesity in a Metabolic Syndrome Porcine Model.

Several studies have suggested a role for gut mucosa-associated microbiota in the development of obesity, but the mechanisms involved are poorly defined. Here, the impact of the gut mucosa-associated microbiota on obesity and related metabolic disorders was evaluated in a metabolic syndrome (MetS) porcine model. Body composition was determined among male Wuzhishan minipigs consuming a high-energy diet (HED) and compared to that of those consuming a normal diet (ND), and gut segments (duodenum, jejunum, ileum, cecum, colon, and rectum) were sampled for paired analysis of mucosa-associated microbiota and transcriptome signatures with 16S rRNA gene and RNA sequencing, respectively.

Transcriptomic Profiling Reveals Underlying Immunoregulation Mechanisms of Resistant Hypertension in Injection Drug Users.

Background: Hypertension is a common complication in injection drug users (IDU), especially a high proportion of resistant hypertension occurs among them. However, the involving mechanisms remain largely unknown.

Methods: We here investigated the key signaling moieties in resistant hypertension in drug users.

Multi-Omic Analysis in a Metabolic Syndrome Porcine Model Implicates Arachidonic Acid Metabolism Disorder as a Risk Factor for Atherosclerosis.

Background: The diet-induced gut microbiota dysbiosis has been suggested as a major risk factor for atherothrombosis, however, the detailed mechanism linking these conditions is yet to be fully understood.

Methods: We established a long-term excessive-energy diet-induced metabolic syndrome (MetS) inbred Wuzhishan minipig model, which is characterized by its genetic stability, small size, and human-like physiology. The metabolic parameters, atherosclerotic lesions, gut microbiome, and host transcriptome were analyzed.

[Effects of Microplastics Addition on Soil Organic Carbon Mineralization in Citrus Orchard].

To investigate the effects of microplastics on soil organic carbon mineralization and the changes in soil enzyme activities, an incubation experiment was conducted whereby single applications of either microplastics or straw, and combined application of both, were added to Dangyang citrus orchard soil. The results showed that the combined application of straw and microplastics significantly affected organic carbon mineralization in the soil, but the single addition of microplastics had no significant effect. Compared with straw alone, the application of a small combined amount of microplastics and straw significantly increased soil organic carbon mineralization by 8.

Cytokine Profiling in Chinese SLE Patients: Correlations with Renal Dysfunction.

Background: Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that commonly causes kidney damage. Therefore, we measured plasma levels of cytokines that may be related to renal dysfunction in SLE patients.

Methods: To explore the differences between SLE patients with renal dysfunction and healthy volunteers, the levels of cytokines in plasma were screened using a human cytokine antibody array.

Unified Classification of Bacterial Colonies on Different Agar Media Based on Hyperspectral Imaging and Machine Learning.

A universal method by considering different types of culture media can enable convenient classification of bacterial species. The study combined hyperspectral technology and versatile chemometric algorithms to achieve the rapid and non-destructive classification of three kinds of bacterial colonies (, and ) cultured on three kinds of agar media (Luria-Bertani agar (LA), plate count agar (PA) and tryptone soy agar (TSA)). Based on the extracted spectral data, partial least squares discriminant analysis (PLS-DA) and support vector machine (SVM) were employed to established classification models.

[Effects of Biochar on NO Emission from Four Typical Soils in the North China Plain].

As a potential soil conditioner, biochar plays an important role in alleviating greenhouse gas (GHG) emissions. To clarify the influence of biochar on soil NO emissions during the winter wheat seedling stage, four typical soils in the North China Plain (paddy soil, shajiang black soil, cinnamon soil, and fluvo-aquic soil) were adopted for field experiments, and four treatments were set:Control (CK), Fertilizer (NPK), Biochar (BC), and Fertilizer+Biochar (NPK+BC). The results showed that fertilization (NPK) significantly increased the NO emissions of the four soils.

Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies.

Objectives: Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.

Methods: A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018.

A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells.

Long non-coding RNA HOXA11 antisense RNA (HOXA11-AS) has been previously reported to be involved in the tumorigenesis and progression of ovarian cancer and glioma. However, the function of HOXA11-AS in lung cancer remains unclear. Following the knockdown of HOXA11-AS in A549 cells, a microarray analysis was performed in order to detect the differences in microRNA (miRNA/miR) profiles.

Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis.

Objective: The relationship between vitamin D and allergic rhinitis (AR) remains unclear. The present study investigated their association by examining serum 25-hydroxyvitamin D (25(OH)D) levels, blood eosinophils, and the expression of vitamin D receptors (VDR) on nasal mucosa in patients with AR.

Methods: A total of 32 patients with persistent AR and 25 controls were enrolled in this study.

Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification.

HOXA11 antisense RNA (HOXA11-AS) has been shown to be involved in tumorigenesis and development of different cancers. However, the role of HOXA11-AS in non-small cell lung cancer (NSCLC) remains unclear. In this study, we firstly explored and confirmed the expression of HOXA11-AS in NSCLC tissues and cells.

Comprehensive analysis of the long noncoding RNA HOXA11-AS gene interaction regulatory network in NSCLC cells.

Background: Long noncoding RNAs (lncRNAs) are related to different biological processes in non-small cell lung cancer (NSCLC). However, the possible molecular mechanisms underlying the effects of the long noncoding RNA HOXA11-AS (HOXA11 antisense RNA) in NSCLC are unknown.

Methods: HOXA11-AS was knocked down in the NSCLC A549 cell line and a high throughput microarray assay was applied to detect changes in the gene profiles of the A549 cells.

Water induced spin-crossover behaviour and magneto-structural correlation in octacyanotungstate(iv)-based iron(ii) complexes.

A series of octacyanotungstate(iv)-based iron(ii) complexes with the general formula Fe(L)[W(CN)]·nHO [L = (3-pyridyl)methanol (1, 2), 3-methylpyridine (3), (4-pyridyl)methanol (4), and 4-methylpyridine (5); n = 4 for 1, and n = 0 for 2-5] have been synthesized and characterized. Single crystal X-ray diffraction analysis reveals that the Fe ions lie in the centre of the compressed [FeN] octahedron in all complexes. Fe and W ions are alternately bridged by cyano groups forming a three-dimensional (3D) bimetallic framework.

Effect of hydrocolloids on the energy consumption and quality of frozen noodles.

Effects of hydrocolloids such as Sodium polyacrylate, xanthan gum and sodium alginate on the energy consumption and quality of frozen cooked noodles were investigated. Results showed that gelatinization temperature (GT) shortened significantly and texture properties (hardness, firmness, break strength) of frozen cooked noodle were significantly improved by adding different hydrocolloid additives (P < 0.05).

Single-Chain Magnets Based on Octacyanotungstate with the Highest Energy Barriers for Cyanide Compounds.

By introducing large counter cations as the spacer, two isolated 3, 3-ladder compounds, (Ph4P)[Co(II)(3-Mepy)2.7(H2O)0.3W(V)(CN)8] · 0.

Efficacy and safety evaluation of a combination of iguratimod and methotrexate therapy for active rheumatoid arthritis patients: a randomized controlled trial.

This study aimed to investigate the efficacy and safety of iguratimod (T-614) in combination with methotrexate (MTX) for active rheumatoid arthritis (RA) patients. Sixty active RA patients were enrolled according to the 2010 American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) classification criteria, and were randomized into MTX + T-614 group and MTX group. T-614 was orally administered at a dosage of 50 mg/day (25 mg twice daily) for 24 weeks.

Experimental Study of Coaxial Cylinder Dielectric Barrier Discharge in Ar/NH3 Mixtures under the Atmosphere-Pressure.

An atmosphere-pressure Dielectric Barrier Discharge in Ar/NH3 mixtures between cylinder electrodes is studied by Optical Emission Spectroscopy and the main particles of atmosphere-pressure Ar/NH3 DBD plasma are NH, N, N+, N2, Ar, H(α) and OH. NH is decomposition products of NH3, and NH(c 1π) and NH(A 3π) are two kinds of excited-state neutral particles and produced by penning ionization of Ar* and NH3. The nitrogen active atom is detected at 674.

Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report.

Primary urinary bladder adenosquamous carcinoma is extremely rare and only a few cases have been reported in English literatures. Its biological behavior remains unclear. Here we reported a 60-year-old male patient with lower limb deep venous thromboses associated with primary urinary bladder adenosquamous carcinoma.

Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues.

Background: Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) has been reported to be associated with the development of various cancers. However, the role of TRAF6 in lung cancer remains unclear.

Objective: To explore the expression and clinicopathological significance of TRAF6 protein in lung cancer tissues.

Advanced glycation end-products impair Na⁺/K⁺-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway.

Decreased Na(+) /K(+) -ATPase activity, and both sirtuin 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK) have been reported to be involved in the development of diabetic cardiomyopathy (DCM). The present study aimed to investigate the advanced glycation end-products (AGE) that impair Na(+) /K(+) -ATPase stability by regulating the AMPK/SIRT1 pathway during progression of DCM. To study type 1 diabetic mellitus (T1DM), a disease model in rats was established by a single intraperitoneal injection of streptozotocin (STZ; 65 mg/kg), and neonatal rat cardiomyocytes were also cultured.

Chiral and achiral imidazole-linked tetrahedral zinc phosphonate frameworks with photoluminescent properties.

Presented here are three imidazole-linked tetrahedral zinc phosphonate frameworks based on a special ligand 2-(1-imidazole)-1-hydroxyl-1,1'-ethylidenediphosphonic acid (= ImhedpH4) with both an organic imidazole linker and inorganic phosphonate groups. Three new compounds, namely, [Zn2(ImhedpH2)2(ox)](H2ppz) (1), Zn3(ImhedpH)2(H2O)4 (2) and [Zn3(Imhedp)2](H2ppz) (3) (ox = oxalate and ppz = piperazine), were obtained by hydrothermal synthesis and structurally characterized by single-crystal X-ray diffraction. Compound 1 shows a chain structure with the ox ligands linking the [Zn2(ImhedpH2)2] units, and the resulting chains are further connected to form a 3D structure through the strong N-H···O and O-H···O hydrogen bonds between the neighboring chains.