Endocr Metab Immune Disord Drug Targets
October 2024
Background: Polycystic Ovary Syndrome (PCOS) is a highly prevalent, complex, heterogeneous, polygenic endocrine disorder characterized by metabolic and reproductive dysfunction that affects 8-13% of women of reproductive age worldwide. The pathogenesis of PCOS has not been fully clarified and includes genetics, obesity, and insulin resistance (IR). Oxidative stress (OS) of PCOS is independent of obesity.
View Article and Find Full Text PDFPhotoactivated therapy has gradually emerged as a promising and rapid method for combating bacteria, aimed at overcoming the emergence of drug-resistant strains resulting from the inappropriate use of antibiotics and the subsequent health risks. In this work, we report the facile fabrication of Zn[Fe(CN)]/g-CN nanocomposites (denoted as ZHF/g-CN) through the in-situ loading of zinc hexacyanoferrate nanospheres onto two-dimensional g-CN sheets using a simple metal-organic frameworks construction method. The ZHF/g-CN nanocomposite exhibits enhanced antibacterial activity through the synergistic combination of the excellent photothermal properties of ZHF and the photodynamic capabilities of g-CN.
View Article and Find Full Text PDFIn the adult mammalian brain, new neurons are continuously generated from neural stem cells (NSCs) in the subventricular zone (SVZ)-olfactory bulb (OB) pathway. YAP, a transcriptional co-activator of the Hippo pathway, promotes cell proliferation and inhibits differentiation in embryonic neural progenitors. However, the role of YAP in postnatal NSCs remains unclear.
View Article and Find Full Text PDFBackground: Idiopathic pulmonary fibrosis (IPF) is a chronic fatal disease with limited therapeutic options. The infiltration of monocytes and fibroblasts into the injured lungs is implicated in IPF. Enolase-1 (ENO1) is a cytosolic glycolytic enzyme which could translocate onto the cell surface and act as a plasminogen receptor to facilitate cell migration via plasmin activation.
View Article and Find Full Text PDFBackground: Quantitative studies on the changes in inflammation-related content in tears, especially the effect of diabetes, are lacking. In this study, we measured the preoperative and postoperative tear inflammatory mediator levels in cataract patients, focusing on the expression of inflammatory factors in postoperative cataracts in the diabetic, and investigated the effect of drugs on the control of postoperative inflammation.
Aim: To study the expression of inflammatory factors in elderly people with type 2 diabetes after cataract surgery.
Front Endocrinol (Lausanne)
November 2022
Context: High progesterone levels in the follicular stage interfere with the implantation window, causing infertility in women with 17-hydroxylase/17,20-lyase deficiency (17OHD). Dexamethasone can restore cortisol deficiency and suppress inappropriate mineralocorticoid secretion to control hypertension in 17OHD patients, but poses risks to the foetus if administered during pregnancy.
Objective: We prospectively explored a rational glucocorticoid use protocol for assistive reproduction in a woman with non-classic 17OHD that reduced glucocorticoid side effects.
Background: The number of obese people continues to increase worldwide, and obesity-related complications add to every country's health burden. Consequently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), are attracting increasing attention. This study sought to assess the cost effectiveness for weight loss of 4 GLP-1RAs in adult patients with obesity in the United States.
View Article and Find Full Text PDFThe relationship between prolactinoma and obesity has not been well explained yet. This report introduced the diagnosis and treatment course of a severely obese male patient. After a series of examinations, the patient was finally diagnosed as prolactinoma after excluding other endocrine-related diseases, like diabetes.
View Article and Find Full Text PDFDevelopments of enantioselective devices for discriminating bio-enantiomers is of significant importance. Due to the vital role of Cysteine (Cys) in biological processes and the hazardous effect of its D-enantiomer, discriminating Cys enantiomers without auxiliary enzyme is highly wanted. In this work, a pair of UiO-MOF enantiomers (UiO-tart) have been fabricated through post-modification, which could be further fabricated into enantiomeric sensing devices (UiO-tart@Au).
View Article and Find Full Text PDFFabrication of metal-organic frameworks (MOFs) based multifunctional sensors for various environmental pollutants represents a promising solution to the development of novel monitoring technologies. In this work, a dual responsive sensor of UiO-66-MA has been efficiently fabricated via post-modification of the UiO-66-MOF with maleic anhydride (MA), and dual detection of HS and Cu in aquatic environments has been achieved tandemly. UiO-66-MA could selectively undergo Michael addition with HS accompanying a linear fluorescence turn-on behavior.
View Article and Find Full Text PDFDevelopment of highly sensitive and selective fluorescent sensors toward hazardous analytes represents great progress in fabricating sensing devices for practical applications. In this work, a highly selective sensor with dual functions has been fabricated via facile postmodification of the UiO-MOF. Butene modified salicylaldehyde is covalently linked to the UiO-66 scaffold via an efficient Schiff-base reaction, resulting in a highly fluorescent ozone sensor of UiO-66-butene.
View Article and Find Full Text PDFDecoding enantioselective molecular interactions between sensors and guests into readable signal represents a great challenge in developing selective sensing technology. In this work, a pair of serine derivatives based homochiral coordination polymer (HCP) enantiomers, (L)-SA-Cd and (D)-SA-Cd, were synthesized and explored as enantioselective sensors towards guest enantiomers. Quartz crystal microbalance (QCM) technology was employed to indicate the gravimetric change of (L)- and (D)-SA-Cd towards variable chiral guests, and an enantioselective factor of 1.
View Article and Find Full Text PDFMetal-organic framework (MOF) assisted hydrothermal pretreatment and co-catalysis strategy based on UiO-66 MOF is developed for the first time. The Planetree exfoliating bark was pretreated with or without UiO-66 assisted hydrothermal method at a temperature ranging from 160 to 240 °C for 1-3 h residence. With the rise of pretreatment severity, the total reducing sugar (TRS) was increased till reached maximum, 180 mg g, in the presence of UiO-66.
View Article and Find Full Text PDFDeveloping a new cellulase-MOF composite system with enhanced stability and reusability for cellulose hydrolysis was aimed. Physical adsorption strategy was employed to fabricate two cellulase composites, and the activity of composite was characterized by hydrolysis of carboxymethyl cellulose. The NH functionalized UiO-66-NH MOF exhibited higher protein loading than the precursor UiO-66, due to the extra anchor sites of NH groups.
View Article and Find Full Text PDFCrystalline materials with multi-catalytic applications are of great value to both fundamental research and practical applications. The platform of metal-organic frameworks (MOFs) is utilized to fabricate a microporous versatile catalyst with high stability. Self-assembly of a flexible ligand, 4-(4-carboxybenzylamino)benzoic acid (H2CBBA), with Co(ii) resulted in a 3D framework, CBBA-Co, with Co3O clusters exposed in the zigzag channels.
View Article and Find Full Text PDFIntroduction: The aim of our study was to evaluate the effect of low-molecular-weight heparin on pregnancy outcomes in women without thrombophilia during in vitro fertilization/intracytoplasmic sperm injection treatment.
Material And Methods: We searched Pubmed, Web of Science, Embase, Cochrane and CNKI (from inception to 2 February 2018). Our study identified randomized controlled trials or quasi-randomized controlled trials comparing low-molecular-weight heparin subcutaneous treatment with no treatment or only luteal support control.
ACS Appl Mater Interfaces
January 2018
Traditional CO sensing technologies suffer from the disadvantages of being bulky and cross-sensitive to interferences such as CO and HO, these issues could be properly tackled by innovating a novel fluorescence-based sensing technology. Metal-organic frameworks (MOFs), which have been widely explored as versatile fluorescence sensors, are still at a standstill for aggregation-induced emission (AIE), and no example of MOFs showing a dynamic AIE activity has been reported yet. Herein, we report a novel MOF, which successfully converts the aggregation-caused quenching of the autologous ligand molecule to be AIE-active upon framework construction and exhibits bright fluorescence in a highly viscous environment, resulting in the first example of MOFs exhibiting a real dynamic AIE activity.
View Article and Find Full Text PDFParkinson's disease (PD) is a movement-associated disorder that specifically affects dopamine-producing neurons. The disease causes demyelation that adversely impacts upon the motor activity of the brain. Currently there are no promising biomarkers for PD; improved understanding of the molecular mechanisms underlying the different pathological stages of PD are required to enable identification of a novel biomarker.
View Article and Find Full Text PDFA 3D metal-organic framework (ADA-Cd=[Cd L (DMF) ]⋅3 H O where H L is (2E,2'E)-3,3'-(anthracene-9,10-diyl)diacrylic acid) constructed from diacrylate substituted anthracene, sharing structural characteristics with some frequently employed anthraquinone-type dye sensitizers, was introduced as an effective sensitizer for anatase TiO to achieve enhanced visible light photocatalytic performance. A facile mechanical mixing procedure was adopted to prepare the co-catalyst denoted as ADA-Cd/TiO , which showed enhanced photodegradation ability, as well as sustainability, towards several dyes under visible light irradiation. Mechanistic studies revealed that ADA-Cd acted as the antenna to harvest visible light energy, generating excited electrons, which were injected to the conduction band (CB) of TiO , facilitating the separation efficiency of charge carriers.
View Article and Find Full Text PDFBackground: Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated. In this study, we sought to investigate the relationship between the risk of CES and SUA levels. We hypothesized that SUA concentrations are associated with CES.
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