Effect of folic acid supplementation on the change of plasma -adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial.

The relationship between folic acid and -adenosylhomocysteine (SAH) is controversial. This study aims to explore the effect of different doses of folic acid supplementation on SAH levels in hypertensive patients and the modification of methylene-tetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A randomized, double-blind, controlled clinical trial was conducted.

[Prevalence of Anxiety and Depression in Hospitalized Patients with Heart Failure].

Objectives: To determine the prevalence of anxiety and depression in hospitalized patients with heart failure.

Methods: From September 2015 to March 2016, 301 patients who were admitted to the cardiac ward of a tertiary hospital for heart failure were consecutively enrolled in this study. They were assessed with the Hospital Anxiety Depression Scale (HADs).

[Inhibitory effect of lentiviral-mediated RNA on the expression of Foxp3 protein in melanoma cells].

Aim: To explore the feasibility of RNA interference in the treatment of melanoma by inhibiting the Foxp3 gene expression in mouse B16 melanoma cells using RNA interference (RNAi) in vitro.

Methods: Small interfering RNA (siRNA) was designed according to Foxp3 gene. A short hairpin RNA (shRNA) lentivirus expression vector was constructed and transfected into mouse B16 cells, and RNA interference was induced in vitro.

[Advances in studies on active components and monomes of the traditional Chinese medicine targeted platelet].

These active components and monomes inhibit thrombosis aimed directly at activation, adhesiveness and aggregation of platelet, thus preventing and curing ischemic cardiovascular and cerebrovascular diseases. Here we summarized the effect of active components and monomes of the traditional Chinese medicine targeted platelet on ischemic cardiovascular and cerebrovascular diseases, to provide references for drug investigation and clinical application.