Publications by authors named "Xiu-Jiao Lin"
Impact of cathepsin K-induced proteoglycans degradation on dentin collagen.
Arch Oral Biol
January 2025
Objectives: This study aimed to investigate the effects of cathepsin K (catK) on proteoglycans (PGs) and the subsequent impacts on dentin collagen degradation.
Materials And Methods: Demineralized dentin samples were prepared and divided into the following groups: deionized water (DW), 0.1 U/mL chondroitinase ABC (C-ABC), and 1 μM odanacatib (ODN).
Article Synopsis
- Cathepsin K (catK) plays a role in the breakdown of dentin collagen, and this study investigates how catK inhibitors might impact dentin erosion.
- Dentin samples were subjected to erosion and then treated with different solutions, including sodium chloride and the catK inhibitor odanacatib, to assess erosive dentin loss and collagen degradation.
- Results showed that treatments with 0.3 M NaCl and 1 μM odanacatib led to less dentin erosion and collagen breakdown compared to the control group, suggesting that catK inhibitors can help manage dentin erosion.
Effects of the application timing of anti-erosive agents on dentin erosion.
J Mech Behav Biomed Mater
December 2022
This in vitro study aimed to evaluate the effects of the application timing of anti-erosive agents on dentin erosion. Eighty dentin specimens with dimensions of 2 × 2 × 2 mm were prepared and randomly divided into 4 groups based on the treatment solutions: 1.23 × 10 μg/ml sodium fluoride (NaF), 120 μg/ml chlorhexidine (CHX), 300 μg/ml quercetin (QUE), and deionized water (DW, negative control).
View Article and Find Full Text PDFObjective: The aim of the present study was to evaluate the in situ/in vivo effect of quercetin on dentin erosion and abrasion.
Methods: Human dentin blocks (2 × 2 × 2 mm) were embedded and assigned to 6 groups: 75 μg/mL, 150 μg/mL and 300 μg/mL quercetin (Q75, Q150, Q300); 120 μg/mL chlorhexidine (CHX, positive control); and deionized water and ethanol (the negative controls). The specimens were treated with the respective solutions for 2 min and then subjected to in situ/in vivo erosive/abrasive challenge for 7 d as follows: in vivo erosion 4 times a day and then in vivo toothbrush abrasion after the first and last erosive challenges of each day.
Effect of quercetin pretreatment on the immediate and aged bond strength of bleached dentin.
J Mech Behav Biomed Mater
November 2022
Article Synopsis
- - The study investigated how quercetin, a natural compound, affects the bond strength of dentin after bleaching treatments, using human dentin blocks pretreated with different concentrations of quercetin before applying a bleaching agent.
- - Dentin blocks were divided into five experimental groups, with some treated solely with deionized water and others with varying concentrations of quercetin, followed by bleaching with hydrogen peroxide.
- - Results indicated that dentin pretreated with quercetin showed significantly higher bond strength compared to those only bleached, especially at concentrations of 75 µg/mL, 150 µg/mL, and 300 µg/mL quercetin.
Objective: This in situ study aimed to evaluate the effects of the inhibitors of matrix metalloproteinases (MMPs) and cysteine cathepsins on dentin erosion.
Materials And Methods: Ten volunteers participated in this study. Each volunteer wore an intraoral appliance containing 4 dentin specimens subjected to different treatments: deionized water as a control, 1 mM 1,10-phenanthroline (an MMP inhibitor), 50 µM E-64 (a cysteine cathepsin inhibitor), and 1 mM 1,10-phenanthroline + 50 µM E-64.
Objective: Controversy exists regarding the effectiveness of delayed toothbrushing in decreasing erosive tooth wear (ETW). The purpose of this systematic review and meta-analysis was to assess the effects of delayed toothbrushing on ETW.
Materials And Methods: This systematic review and meta-analysis was conducted according to the PRISMA statement and registered in PROSPERO (CRD42020200463).
Effects of remaining dentin thickness on the bond strength of bleached dentin.
BMC Oral Health
August 2020
Background: The bond strength of resin composites to dentin was reported to be related to either the remaining dentin thickness (RDT) or bleaching treatment. However, information is limited regarding the effects of RDT on the bond strength of bleached dentin. The present study aimed to investigate the effects of RDT on the microshear bond strength (μSBS) of resin cement to bleached dentin.
View Article and Find Full Text PDFBackground: The aim of this study was to investigate the amount and sources of stress in dental undergraduate students in Fujian, China, and the factors associated with stress.
Methods: This cross-sectional study was conducted during the second semester of the 2017-2018 academic year at the School of Stomatology, Fujian Medical University, China. A total of 396 students were surveyed with the Dental Environment Stress Questionnaire (DES) and the Perceived Stress Scale (PSS) using an online survey system.
Background: To assess the knowledge of and attitudes towards erosive tooth wear among dental, medical, and non-medical university students of two Chinese universities.
Methods: A questionnaire containing 15 questions on knowledge of erosive tooth wear and 10 questions on attitudes towards erosive tooth wear was designed, and its psychometric properties (reliability and validity) were analysed in a pilot study (n = 120 students). The following 3 groups of university students (n = 635) were recruited based on a convenience sampling technique and were distributed the questionnaire via an online survey system: dental students (DSs), medical students (MSs), and non-medical students (NSs).