Publications by authors named "Xiu-Guo Li"
Objective: The aim of this study was to investigate the effects and mechanism of thalidomide on pancreatic stellate cell (PSC) activation in mice and to find the optimal timing of thalidomide administration.
Methods: PSCs, isolated from mouse pancreas tissue, were divided into five groups with specific treatments: (A) control PSCs (PSC), (B) PSCs induced by TGF-β1 (PSC+TGF-β1), (C) PSCs induced by TGF-β1 followed by thalidomide (PSC+TGF-β1+Thalidomide), (D) PSCs receiving TGF-β1 and thalidomide simultaneously (PSC+(TGF-β1+Thalidomide)), and (E) PSCs treated with thalidomide only (PSC+Thalidomide). We measured the effects of thalidomide on PSC activation by detecting the expression of α-SMA, collagen type I, and the TGF-β/Smad pathway through quantitative real-time PCR and Western blot analysis.
[Inhibitory Effects of Sphingosine-1-phosphate Receptor-2 on Vascular Permeability in Mice].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2016
Objectives: To determine the effect of sphingosine-1-phosphate receptor 2 (S1PR2) on vascular permeability in mice.
Methods: Acute lung injury models of mice were constructed with intra-tracheal administration of lipopolysaccharide (LPS) and compared with the controls with intra-tracheal administration of saline. The effect of S1PR2 on vascular permeability was observed by detecting leakage of Evans blue into lung tissues, pulmonary vascular leakage of fluorescein isothiocyanate (FITC)-dextran, and the wet/dry mass ratio of lungs.
[Severe complications in the treatment of chronic rhinosinusitis and nasal polyps with endoscopic sinus surgery].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2007
Article Synopsis
- The study looked at serious problems that can happen during sinus surgery for people with sinus issues.
- Out of 1,102 patients, 21 had severe complications, like bleeding or injuries to the eyes or brain.
- The most important reasons for these serious problems were how skilled the surgeon was and the patient's previous health issues.
[Expression and meaning of three neuropeptides in the initial stage of recurring nasal polyp].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
April 2006
[Resection of tumors involving the cranio-naso-orbital area via fronto-orbito-ethmoidal approach].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2005
Objective: To introduce a better surgical approach for the resection of tumors involving the anterior and middle skull base and the fronto-orbito-ethmoidal area.
Methods: A "T" form incision was made in the fronto-orbito-ethmoidal region and along the nasal pyramid down. Parts of ethmoid sinus, lamina papyracea, fronto-orbito bone and behind wall of frontal sinus were resected in order to expose the tumors in the anterior skull base and the fronto-orbito-ethmoidal region.