[Effects of soy isoflavone on the reproductive system development and ER-beta expression in male rat offspring in different postnatal periods].

Objective: To investigate the effects of pre- and post-natal exposure to soy isoflavones (SIF) on the related indicators of the reproductive system development and ER-beta expression in male rat offspring.

Methods: Pregnant SD rats were randomly divided into a corn oil group (control), 3 SIF groups (50, 200 and 400 mg/kg body weight), and a diethylstilbestrol (DES, 0.1 mg/ kg body weight) group to be treated respectively by intragastric gavage from pregnancy day 0.