Publications by authors named "Xiu-E Ma"
Ca-induced Ca release (CICR) from sarcoplasmic reticulum is a finely tuned process responsible for cardiac excitation and contraction. The ubiquitin-proteasome system (UPS) as a major degradative system plays a crucial role in the maintenance of Ca homeostasis. The E3 component N-recognin (UBR) subfamily is a part of the UPS; however, the role of UBR in regulating cardiac CICR is unknown.
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- The study investigates the cellular mechanisms behind primary varicose great saphenous veins (GSVs), highlighting the roles of inflammation, cell death (apoptosis), cell growth (proliferation), and the breakdown of structural proteins (extracellular matrix degradation).
- Researchers focused on the long non-coding RNA (lncRNA) GAS5, finding that lower levels of GAS5 lead to increased cell growth and migration in human saphenous vein smooth muscle cells (HSVSMCs).
- The study also revealed that GAS5 interacts with Annexin A2, a calcium-dependent RNA-binding protein, indicating that low GAS5 levels promote GSVs' development by enhancing HSVSMCs proliferation and migration through
MicroRNAs (miRNAs) are a class of small non-coding RNAs, whose expression levels vary in different cell types and tissues. Emerging evidence indicates that tissue-specific and -enriched miRNAs are closely associated with cellular development and stress responses in their tissues. MiR-25 has been documented to be abundant in cardiomyocytes, but its function in the heart remains unknown.
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