Publications by authors named "Xiu Zhen Ye"
Article Synopsis
- - The study focused on creating a real-time risk prediction model for extrauterine growth retardation (EUGR) in very preterm infants, utilizing data from 2,514 infants split into training and validation sets.
- - Key predictors, including birth weight, small for gestational age, and others, were identified and used in a logistic regression model, with a nomogram visualization to help assess risk.
- - The model demonstrated strong predictive ability, achieving ROC curve areas of 83.1% and 84.6% for the training and validation sets, respectively, and indicating good calibration and clinical applicability for risk assessment.
Background: Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear.
Methods: A secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal HGP, all infants were divided into the HGP group or the non-HGP group.
Article Synopsis
- NEC is a serious illness that mostly affects premature babies, showing up usually after they are a week old.
- This study looked at data from over 2,500 premature babies to understand the causes of late-onset NEC and how it affects their health in the short term, especially focusing on their nutrition.
- Results showed that babies with late-onset NEC faced more health issues like anemia and required more treatments, had slower weight gain, and breastfeeding rates were lower among them.
Background: To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using the ΔZ value of weight at discharge.
Methods: The clinical data were collected from 28 hospitals in China from September 2019 to December 2020. They were divided into the EUGR(Extrauterine Growth Restriction) and the non-EUGR group according to the criterion of ΔZ value of weight at discharge < -1.
Objectives: The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there is no consensus on the optimal time point after birth at which enteral nutrition can be started. The aim of this study was to investigate the effect of early initiation of enteral nutrition on the short-term clinical outcomes of VPIs.
Methods: Data of infants (n = 2514) born before 32 wk of gestation were collected from 28 hospitals located in seven different regions of China.
[Value of functional echocardiographic parameters in predicting refractory septic shock in neonates].
Zhongguo Dang Dai Er Ke Za Zhi
November 2022
Objectives: To study the value of functional echocardiographic parameters in predicting refractory septic shock in neonates.
Methods: A total of 72 neonates with septic shock were enrolled. According to the highest value of septic shock score, they were divided into two groups: refractory (=30) and non-refractory (=42).
Background: The incidence of extrauterine growth retardation (EUGR) varies considerably in different countries due to the distinct definitions and inclusion criteria of individual studies. Most studies included small for gestational age (SGA) very preterm infants (VPIs), resulting in a higher incidence of EUGR. Experts have suggested the accurate definition of "EUGR" in SGA infants is not "true EUGR".
View Article and Find Full Text PDFObjective: To investigate the incidence and related factors of extrauterine growth retardation (EUGR) and "true EUGR" in very preterm infants (VPI) from different regions of China.
Materials And Methods: Clinical data of VPI were prospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020. The infants were divided into a small for gestational age (SGA) group or non-SGA group at birth, with non-SGA infants at 36 weeks of gestation or at discharge being further divided into a EUGR group or a non-EUGR group.
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units in Guangdong Province of China during 2008-2017 were analyzed.
View Article and Find Full Text PDFObjective: Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine growth restriction, EUGR). This multi-center retrospective study investigated risk factors of EUGR, specifically in very preterm infants with BPD.
View Article and Find Full Text PDFObjectives: To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization in China.
Methods: A prospective multicenter study was performed on the medical data of 2 514 VPIs who were hospitalized in the department of neonatology in 28 hospitals from 7 areas of China between September 2019 and December 2020. According to the presence or absence of EUGR based on the evaluation of body weight at the corrected gestational age of 36 weeks or at discharge, the VPIs were classified to two groups: EUGR group (=1 189) and non-EUGR (=1 325).
Objectives: To investigate the clinical treatment outcomes and the changes of the outcomes over time in extremely preterm twins in Guangdong Province, China.
Methods: A retrospective analysis was performed for 269 pairs of extremely preterm twins with a gestational age of <28 weeks who were admitted to the department of neonatology in 26 grade A tertiary hospitals in Guangdong Province from January 2008 to December 2017. According to the admission time, they were divided into two groups: 2008-2012 and 2013-2017.
Article Synopsis
- PPARγ is a crucial transcription factor involved in regulating various biological processes such as fat cell development, lipid metabolism, and insulin sensitivity, pointing to its significance in maintaining overall metabolic health.
- PPARγ also plays a vital role in heart cell function and is essential for proper placental development, impacting embryonic survival.
- In studies with neonatal mice lacking PPARγ, severe metabolic disorders emerged shortly after birth, indicating that PPARγ1 is important for neonatal health and metabolic functions, particularly regarding lipid and glucose metabolism as well as insulin sensitivity.